메뉴 건너뛰기




Volumn 5, Issue 6, 2010, Pages

Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIN DEPENDENT KINASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B KINASE; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEASOME; PROTEIN KINASE B; PROTEIN MDM2; RNA; SIRTUIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FOXO; UBIQUITIN PROTEIN LIGASE E3; FORKHEAD TRANSCRIPTION FACTOR;

EID: 77956217791     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011092     Document Type: Article
Times cited : (30)

References (137)
  • 1
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24: 7410-7425.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 2
    • 41849093037 scopus 로고    scopus 로고
    • The role of FoxO in the regulation of metabolism
    • Gross DN, van den Heuvel AP, Birnbaum MJ (2008) The role of FoxO in the regulation of metabolism. Oncogene 27: 2320-2336.
    • (2008) Oncogene , vol.27 , pp. 2320-2336
    • Gross, D.N.1    van den Heuvel, A.P.2    Birnbaum, M.J.3
  • 3
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A (2007) PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 4
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 5
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans life-span and metabolism
    • Lee SS, Kennedy S, Tolonen AC, Ruvkun G (2003) DAF-16 target genes that control C. elegans life-span and metabolism. Science 300: 644-647.
    • (2003) Science , vol.300 , pp. 644-647
    • Lee, S.S.1    Kennedy, S.2    Tolonen, A.C.3    Ruvkun, G.4
  • 6
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121.
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 7
    • 7244238167 scopus 로고    scopus 로고
    • Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    • McElwee JJ, Schuster E, Blanc E, Thomas JH, Gems D (2004) Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem 279: 44533-44543.
    • (2004) J Biol Chem , vol.279 , pp. 44533-44543
    • McElwee, J.J.1    Schuster, E.2    Blanc, E.3    Thomas, J.H.4    Gems, D.5
  • 8
    • 0037448528 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    • Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, et al. (2003) Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421: 268-272.
    • (2003) Nature , vol.421 , pp. 268-272
    • Ashrafi, K.1    Chang, F.Y.2    Watts, J.L.3    Fraser, A.G.4    Kamath, R.S.5
  • 9
    • 13844298645 scopus 로고    scopus 로고
    • Gene expression profile of long-lived Ames dwarf mice and Little mice
    • Amador-Noguez D, Yagi K, Venable S, Darlington G (2004) Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell 3: 423-441.
    • (2004) Aging Cell , vol.3 , pp. 423-441
    • Amador-Noguez, D.1    Yagi, K.2    Venable, S.3    Darlington, G.4
  • 10
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    • Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, et al. (2007) An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17: 1646-1656.
    • (2007) Curr Biol , vol.17 , pp. 1646-1656
    • Greer, E.L.1    Dowlatshahi, D.2    Banko, M.R.3    Villen, J.4    Hoang, K.5
  • 11
    • 34848861463 scopus 로고    scopus 로고
    • The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    • Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, et al. (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 282: 30107-30119.
    • (2007) J Biol Chem , vol.282 , pp. 30107-30119
    • Greer, E.L.1    Oskoui, P.R.2    Banko, M.R.3    Maniar, J.M.4    Gygi, M.P.5
  • 12
    • 34248207609 scopus 로고    scopus 로고
    • High-resolution dynamics of the transcriptional response to nutrition in Drosophila: A key role for dFOXO
    • Gershman B, Puig O, Hang L, Peitzsch RM, Tatar M, et al. (2007) High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. Physiol Genomics 29: 24-34.
    • (2007) Physiol Genomics , vol.29 , pp. 24-34
    • Gershman, B.1    Puig, O.2    Hang, L.3    Peitzsch, R.M.4    Tatar, M.5
  • 13
    • 46749114798 scopus 로고    scopus 로고
    • Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
    • Yu RX, Liu J, True N, Wang W (2008) Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16. PLoS One 3: e1821.
    • (2008) PLoS One , vol.3
    • Yu, R.X.1    Liu, J.2    True, N.3    Wang, W.4
  • 14
    • 31744438846 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, et al. (2006) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet 38: 251-257.
    • (2006) Nat Genet , vol.38 , pp. 251-257
    • Oh, S.W.1    Mukhopadhyay, A.2    Dixit, B.L.3    Raha, T.4    Green, M.R.5
  • 15
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201-1204.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 16
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, et al. (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 168: 5024-5031.
    • (2002) J Immunol , vol.168 , pp. 5024-5031
    • Stahl, M.1    Dijkers, P.F.2    Kops, G.J.3    Lens, S.M.4    Coffer, P.J.5
  • 17
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613-622.
    • (2003) J Cell Biol , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 18
    • 33646189483 scopus 로고    scopus 로고
    • RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells
    • Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y (2006) RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem 281: 5267-5276.
    • (2006) J Biol Chem , vol.281 , pp. 5267-5276
    • Yamamura, Y.1    Lee, W.L.2    Inoue, K.3    Ida, H.4    Ito, Y.5
  • 19
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    • Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, et al. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419: 316-321.
    • (2002) Nature , vol.419 , pp. 316-321
    • Kops, G.J.1    Dansen, T.B.2    Polderman, P.E.3    Saarloos, I.4    Wirtz, K.W.5
  • 20
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, et al. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534.
    • (2002) Science , vol.296 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3    Datta, S.R.4    Fornace Jr, A.J.5
  • 21
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le HV, Shen L, Anderson SA, Massague J (2004) Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 23
    • 1642580499 scopus 로고    scopus 로고
    • FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1
    • Bakker WJ, Blazquez-Domingo M, Kolbus A, Besooyen J, Steinlein P, et al. (2004) FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol 164: 175-184.
    • (2004) J Cell Biol , vol.164 , pp. 175-184
    • Bakker, W.J.1    Blazquez-Domingo, M.2    Kolbus, A.3    Besooyen, J.4    Steinlein, P.5
  • 24
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404: 782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 25
    • 0034459180 scopus 로고    scopus 로고
    • Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1)
    • Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, et al. (2000) Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol 20: 9138-9148.
    • (2000) Mol Cell Biol , vol.20 , pp. 9138-9148
    • Dijkers, P.F.1    Medema, R.H.2    Pals, C.3    Banerji, L.4    Thomas, N.S.5
  • 27
    • 0033560896 scopus 로고    scopus 로고
    • Direct control of the Forkhead transcription factor AFX by protein kinase B
    • Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, et al. (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398: 630-634.
    • (1999) Nature , vol.398 , pp. 630-634
    • Kops, G.J.1    de Ruiter, N.D.2    De Vries-Smits, A.M.3    Powell, D.R.4    Bos, J.L.5
  • 28
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • Matsumoto M, Han S, Kitamura T, Accili D (2006) Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 116: 2464-2472.
    • (2006) J Clin Invest , vol.116 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3    Accili, D.4
  • 29
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto S, Fergusson MM, Finkel T (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306: 2105-2108.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 30
    • 26944461217 scopus 로고    scopus 로고
    • Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    • Puig O, Tjian R (2005) Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev 19: 2435-2446.
    • (2005) Genes Dev , vol.19 , pp. 2435-2446
    • Puig, O.1    Tjian, R.2
  • 31
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y, Honda S (1999) The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. Faseb J 13: 1385-1393.
    • (1999) Faseb J , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 32
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 33
    • 0032759047 scopus 로고    scopus 로고
    • Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
    • Kops GJ, Burgering BM (1999) Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med 77: 656-665.
    • (1999) J Mol Med , vol.77 , pp. 656-665
    • Kops, G.J.1    Burgering, B.M.2
  • 34
    • 33749346063 scopus 로고    scopus 로고
    • Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis
    • Yang JY, Xia W, Hu MC (2006) Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol 29: 643-648.
    • (2006) Int J Oncol , vol.29 , pp. 643-648
    • Yang, J.Y.1    Xia, W.2    Hu, M.C.3
  • 35
    • 0038363836 scopus 로고    scopus 로고
    • Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
    • Imae M, Fu Z, Yoshida A, Noguchi T, Kato H (2003) Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J Mol Endocrinol 30: 253-262.
    • (2003) J Mol Endocrinol , vol.30 , pp. 253-262
    • Imae, M.1    Fu, Z.2    Yoshida, A.3    Noguchi, T.4    Kato, H.5
  • 36
    • 67449100489 scopus 로고    scopus 로고
    • The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors
    • Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB (2009) The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem 284: 10334-10342.
    • (2009) J Biol Chem , vol.284 , pp. 10334-10342
    • Essaghir, A.1    Dif, N.2    Marbehant, C.Y.3    Coffer, P.J.4    Demoulin, J.B.5
  • 39
    • 36749079110 scopus 로고    scopus 로고
    • Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification
    • Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, et al. (2007) Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Res 35: 6984-6994.
    • (2007) Nucleic Acids Res , vol.35 , pp. 6984-6994
    • Tsai, K.L.1    Sun, Y.J.2    Huang, C.Y.3    Yang, J.Y.4    Hung, M.C.5
  • 40
    • 50849130900 scopus 로고    scopus 로고
    • Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification
    • Brent MM, Anand R, Marmorstein R (2008) Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. Structure 16: 1407-1416.
    • (2008) Structure , vol.16 , pp. 1407-1416
    • Brent, M.M.1    Anand, R.2    Marmorstein, R.3
  • 41
    • 3142749712 scopus 로고    scopus 로고
    • Long-lived Drosophila with overexpressed dFOXO in adult fat body
    • Giannakou ME, Goss M, Junger MA, Hafen E, Leevers SJ, et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361.
    • (2004) Science , vol.305 , pp. 361
    • Giannakou, M.E.1    Goss, M.2    Junger, M.A.3    Hafen, E.4    Leevers, S.J.5
  • 42
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429: 562-566.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gershman, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 43
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang MC, Bohmann D, Jasper H (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 44
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, et al. (2005) JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 102: 4494-4499.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4494-4499
    • Oh, S.W.1    Mukhopadhyay, A.2    Svrzikapa, N.3    Jiang, F.4    Davis, R.J.5
  • 45
    • 33646934067 scopus 로고    scopus 로고
    • A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    • Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001.
    • (2006) Cell , vol.125 , pp. 987-1001
    • Lehtinen, M.K.1    Yuan, Z.2    Boag, P.R.3    Yang, Y.4    Villen, J.5
  • 46
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 47
    • 59649120539 scopus 로고    scopus 로고
    • Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    • Honjoh S, Yamamoto T, Uno M, Nishida E (2009) Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature 457: 726-730.
    • (2009) Nature , vol.457 , pp. 726-730
    • Honjoh, S.1    Yamamoto, T.2    Uno, M.3    Nishida, E.4
  • 48
    • 0042886011 scopus 로고    scopus 로고
    • Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans
    • Houthoofd K, Braeckman BP, Johnson TE, Vanfleteren JR (2003) Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp Gerontol 38: 947-954.
    • (2003) Exp Gerontol , vol.38 , pp. 947-954
    • Houthoofd, K.1    Braeckman, B.P.2    Johnson, T.E.3    Vanfleteren, J.R.4
  • 49
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8: 113-127.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 51
    • 67651151249 scopus 로고    scopus 로고
    • Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
    • Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, et al. (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8: 460-472.
    • (2009) Aging Cell , vol.8 , pp. 460-472
    • Pawlikowska, L.1    Hu, D.2    Huntsman, S.3    Sung, A.4    Chu, C.5
  • 55
    • 41549135942 scopus 로고    scopus 로고
    • FoxO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih DA, Brunet A (2008) FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20: 126-136.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 56
    • 41849136901 scopus 로고    scopus 로고
    • Forkhead transcription factors and ageing
    • Partridge L, Bruning JC (2008) Forkhead transcription factors and ageing. Oncogene 27: 2351-2363.
    • (2008) Oncogene , vol.27 , pp. 2351-2363
    • Partridge, L.1    Bruning, J.C.2
  • 57
    • 41849150779 scopus 로고    scopus 로고
    • FOXOs, cancer and regulation of apoptosis
    • Fu Z, Tindall DJ (2008) FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312-2319.
    • (2008) Oncogene , vol.27 , pp. 2312-2319
    • Fu, Z.1    Tindall, D.J.2
  • 58
    • 41849114197 scopus 로고    scopus 로고
    • Foxo in the immune system
    • Peng SL (2008) Foxo in the immune system. Oncogene 27: 2337-2344.
    • (2008) Oncogene , vol.27 , pp. 2337-2344
    • Peng, S.L.1
  • 59
    • 33747370384 scopus 로고    scopus 로고
    • Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    • Arden KC (2006) Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol 41: 709-717.
    • (2006) Exp Gerontol , vol.41 , pp. 709-717
    • Arden, K.C.1
  • 60
    • 41849104205 scopus 로고    scopus 로고
    • Structure/function relationships underlying regulation of FOXO transcription factors
    • Obsil T, Obsilova V (2008) Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene 27: 2263-2275.
    • (2008) Oncogene , vol.27 , pp. 2263-2275
    • Obsil, T.1    Obsilova, V.2
  • 61
    • 41849086320 scopus 로고    scopus 로고
    • FOXO-binding partners: It takes two to tango
    • van der Vos KE, Coffer PJ (2008) FOXO-binding partners: it takes two to tango. Oncogene 27: 2289-2299.
    • (2008) Oncogene , vol.27 , pp. 2289-2299
    • van der Vos, K.E.1    Coffer, P.J.2
  • 62
    • 2942726155 scopus 로고    scopus 로고
    • The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation
    • Van Der Heide LP, Hoekman MF, Smidt MP (2004) The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 380: 297-309.
    • (2004) Biochem J , vol.380 , pp. 297-309
    • van der Heide, L.P.1    Hoekman, M.F.2    Smidt, M.P.3
  • 63
    • 62649089279 scopus 로고    scopus 로고
    • Insulin and JNK: Optimizing metabolic homeostasis and lifespan
    • Karpac J, Jasper H (2009) Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab 20: 100-106.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 100-106
    • Karpac, J.1    Jasper, H.2
  • 64
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • van der Horst A, Burgering BM (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 440-450
    • van der Horst, A.1    Burgering, B.M.2
  • 65
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine AJ, Feng Z, Mak TW, You H, Jin S (2006) Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 20: 267-275.
    • (2006) Genes Dev , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 66
    • 44349125602 scopus 로고    scopus 로고
    • Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
    • Schmierer B, Tournier AL, Bates PA, Hill CS (2008) Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc Natl Acad Sci U S A 105: 6608-6613.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6608-6613
    • Schmierer, B.1    Tournier, A.L.2    Bates, P.A.3    Hill, C.S.4
  • 67
    • 34250155259 scopus 로고    scopus 로고
    • Nucleocytoplasmic oscillations of the yeast transcription factor Msn2: Evidence for periodic PKA activation
    • Garmendia-Torres C, Goldbeter A, Jacquet M (2007) Nucleocytoplasmic oscillations of the yeast transcription factor Msn2: evidence for periodic PKA activation. Curr Biol 17: 1044-1049.
    • (2007) Curr Biol , vol.17 , pp. 1044-1049
    • Garmendia-Torres, C.1    Goldbeter, A.2    Jacquet, M.3
  • 68
    • 46249127273 scopus 로고    scopus 로고
    • Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast
    • Gonze D, Jacquet M, Goldbeter A (2008) Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast. J R Soc Interface 5: Suppl 1 S95-109.
    • (2008) J R Soc Interface , vol.5 , Issue.SUPPL. 1
    • Gonze, D.1    Jacquet, M.2    Goldbeter, A.3
  • 69
    • 7444254365 scopus 로고    scopus 로고
    • Oscillations in NF-kappaB signaling control the dynamics of gene expression
    • Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, et al. (2004) Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science 306: 704-708.
    • (2004) Science , vol.306 , pp. 704-708
    • Nelson, D.E.1    Ihekwaba, A.E.2    Elliott, M.3    Johnson, J.R.4    Gibney, C.A.5
  • 70
    • 53149144701 scopus 로고    scopus 로고
    • Explaining oscillations and variability in the p53-Mdm2 system
    • Proctor CJ, Gray DA (2008) Explaining oscillations and variability in the p53-Mdm2 system. BMC Syst Biol 2: 75.
    • (2008) BMC Syst Biol , vol.2 , pp. 75
    • Proctor, C.J.1    Gray, D.A.2
  • 71
    • 50149107827 scopus 로고    scopus 로고
    • Oscillations and bistability in the stochastic model of p53 regulation
    • Puszynski K, Hat B, Lipniacki T (2008) Oscillations and bistability in the stochastic model of p53 regulation. J Theor Biol 254: 452-465.
    • (2008) J Theor Biol , vol.254 , pp. 452-465
    • Puszynski, K.1    Hat, B.2    Lipniacki, T.3
  • 72
    • 58549117870 scopus 로고    scopus 로고
    • Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
    • Csikasz-Nagy A, Kapuy O, Toth A, Pal C, Jensen LJ, et al. (2009) Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Syst Biol 5: 236.
    • (2009) Mol Syst Biol , vol.5 , pp. 236
    • Csikasz-Nagy, A.1    Kapuy, O.2    Toth, A.3    Pal, C.4    Jensen, L.J.5
  • 74
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5
  • 75
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A 96: 7421-7426.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7421-7426
    • Biggs III, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 76
    • 20144365700 scopus 로고    scopus 로고
    • Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
    • Frescas D, Valenti L, Accili D (2005) Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280: 20589-20595.
    • (2005) J Biol Chem , vol.280 , pp. 20589-20595
    • Frescas, D.1    Valenti, L.2    Accili, D.3
  • 77
    • 0037160050 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
    • Zhang X, Gan L, Pan H, Guo S, He X, et al. (2002) Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem 277: 45276-45284.
    • (2002) J Biol Chem , vol.277 , pp. 45276-45284
    • Zhang, X.1    Gan, L.2    Pan, H.3    Guo, S.4    He, X.5
  • 78
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
    • Matsuzaki H, Daitoku H, Hatta M, Tanaka K, Fukamizu A (2003) Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A 100: 11285-11290.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Tanaka, K.4    Fukamizu, A.5
  • 79
    • 0141481091 scopus 로고    scopus 로고
    • FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
    • Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, et al. (2003) FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem 278: 35959-35967.
    • (2003) J Biol Chem , vol.278 , pp. 35959-35967
    • Jacobs, F.M.1    van der Heide, L.P.2    Wijchers, P.J.3    Burbach, J.P.4    Hoekman, M.F.5
  • 80
    • 0035135841 scopus 로고    scopus 로고
    • Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    • Brunet A, Park J, Tran H, Hu LS, Hemmings BA, et al. (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-965.
    • (2001) Mol Cell Biol , vol.21 , pp. 952-965
    • Brunet, A.1    Park, J.2    Tran, H.3    Hu, L.S.4    Hemmings, B.A.5
  • 81
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang H, Regan KM, Lou Z, Chen J, Tindall DJ (2006) CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314: 294-297.
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 82
    • 0036566003 scopus 로고    scopus 로고
    • Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion
    • Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, et al. (2002) Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. Embo J 21: 2263-2271.
    • (2002) Embo J , vol.21 , pp. 2263-2271
    • Rena, G.1    Woods, Y.L.2    Prescott, A.R.3    Peggie, M.4    Unterman, T.G.5
  • 83
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, et al. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. Embo J 23: 4802-4812.
    • (2004) Embo J , vol.23 , pp. 4802-4812
    • Essers, M.A.1    Weijzen, S.2    de Vries-Smits, A.M.3    Saarloos, I.4    de Ruiter, N.D.5
  • 84
    • 3042750643 scopus 로고    scopus 로고
    • Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    • Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, et al. (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 101: 10042-10047.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10042-10047
    • Daitoku, H.1    Hatta, M.2    Matsuzaki, H.3    Aratani, S.4    Ohshima, T.5
  • 86
    • 38149065992 scopus 로고    scopus 로고
    • An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
    • Proctor CJ, Tsirigotis M, Gray DA (2007) An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline. BMC Syst Biol 1: 17.
    • (2007) BMC Syst Biol , vol.1 , pp. 17
    • Proctor, C.J.1    Tsirigotis, M.2    Gray, D.A.3
  • 88
    • 0037342537 scopus 로고    scopus 로고
    • The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models
    • Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, et al. (2003) The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19: 524-531.
    • (2003) Bioinformatics , vol.19 , pp. 524-531
    • Hucka, M.1    Finney, A.2    Sauro, H.M.3    Bolouri, H.4    Doyle, J.C.5
  • 92
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • Furuyama T, Nakazawa T, Nakano I, Mori N (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349: 629-634.
    • (2000) Biochem J , vol.349 , pp. 629-634
    • Furuyama, T.1    Nakazawa, T.2    Nakano, I.3    Mori, N.4
  • 93
    • 58549110646 scopus 로고    scopus 로고
    • How to deal with large models?
    • Hlavacek WS (2009) How to deal with large models? Mol Syst Biol 5: 240.
    • (2009) Mol Syst Biol , vol.5 , pp. 240
    • Hlavacek, W.S.1
  • 94
    • 67649756744 scopus 로고    scopus 로고
    • MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation
    • Fu W, Ma Q, Chen L, Li P, Zhang M, et al. (2009) MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem 284: 13987-14000.
    • (2009) J Biol Chem , vol.284 , pp. 13987-14000
    • Fu, W.1    Ma, Q.2    Chen, L.3    Li, P.4    Zhang, M.5
  • 95
    • 3142742707 scopus 로고    scopus 로고
    • FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
    • van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, et al. (2004) FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 279: 28873-28879.
    • (2004) J Biol Chem , vol.279 , pp. 28873-28879
    • van der Horst, A.1    Tertoolen, L.G.2    de Vries-Smits, L.M.3    Frye, R.A.4    Medema, R.H.5
  • 96
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5
  • 97
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, et al. (2005) FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2: 153-163.
    • (2005) Cell Metab , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5
  • 98
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225-237.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3    Golfman, L.S.4    Ou-Yang, F.5
  • 99
    • 23844485211 scopus 로고    scopus 로고
    • Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
    • Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, et al. (2005) Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A 102: 11278-11283.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11278-11283
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Aoyama, H.4    Yoshimochi, K.5
  • 101
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3    Kamel, C.4    Chen, D.5
  • 102
    • 4143050290 scopus 로고    scopus 로고
    • The interaction between FOXO and SIRT1: Tipping the balance towards survival
    • Giannakou ME, Partridge L (2004) The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol 14: 408-412.
    • (2004) Trends Cell Biol , vol.14 , pp. 408-412
    • Giannakou, M.E.1    Partridge, L.2
  • 103
    • 0038645860 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
    • Hirota K, Daitoku H, Matsuzaki H, Araya N, Yamagata K, et al. (2003) Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem 278: 13056-13060.
    • (2003) J Biol Chem , vol.278 , pp. 13056-13060
    • Hirota, K.1    Daitoku, H.2    Matsuzaki, H.3    Araya, N.4    Yamagata, K.5
  • 104
    • 0035958853 scopus 로고    scopus 로고
    • Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions
    • Zhao HH, Herrera RE, Coronado-Heinsohn E, Yang MC, Ludes-Meyers JH, et al. (2001) Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. J Biol Chem 276: 27907-27912.
    • (2001) J Biol Chem , vol.276 , pp. 27907-27912
    • Zhao, H.H.1    Herrera, R.E.2    Coronado-Heinsohn, E.3    Yang, M.C.4    Ludes-Meyers, J.H.5
  • 105
    • 0035823576 scopus 로고    scopus 로고
    • Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family
    • Schuur ER, Loktev AV, Sharma M, Sun Z, Roth RA, et al. (2001) Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. J Biol Chem 276: 33554-33560.
    • (2001) J Biol Chem , vol.276 , pp. 33554-33560
    • Schuur, E.R.1    Loktev, A.V.2    Sharma, M.3    Sun, Z.4    Roth, R.A.5
  • 106
    • 34848838902 scopus 로고    scopus 로고
    • A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    • Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, et al. (2007) A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest 117: 2477-2485.
    • (2007) J Clin Invest , vol.117 , pp. 2477-2485
    • Kitamura, T.1    Kitamura, Y.I.2    Funahashi, Y.3    Shawber, C.J.4    Castrillon, D.H.5
  • 107
    • 33846208251 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
    • Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, et al. (2007) Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 19: 519-527.
    • (2007) Cell Signal , vol.19 , pp. 519-527
    • Asada, S.1    Daitoku, H.2    Matsuzaki, H.3    Saito, T.4    Sudo, T.5
  • 108
    • 18844424923 scopus 로고    scopus 로고
    • The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei
    • Kondo M, Yanase S, Ishii T, Hartman PS, Matsumoto K, et al. (2005) The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech Ageing Dev 126: 642-647.
    • (2005) Mech Ageing Dev , vol.126 , pp. 642-647
    • Kondo, M.1    Yanase, S.2    Ishii, T.3    Hartman, P.S.4    Matsumoto, K.5
  • 109
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, et al. (2008) ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 10: 138-148.
    • (2008) Nat Cell Biol , vol.10 , pp. 138-148
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3    Yamaguchi, H.4    Ding, Q.5
  • 110
    • 53949087832 scopus 로고    scopus 로고
    • Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
    • Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, et al. (2008) Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell 32: 221-231.
    • (2008) Mol Cell , vol.32 , pp. 221-231
    • Yamagata, K.1    Daitoku, H.2    Takahashi, Y.3    Namiki, K.4    Hisatake, K.5
  • 111
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3    McDonald III, E.R.4    Hurov, K.E.5
  • 112
    • 54449092731 scopus 로고    scopus 로고
    • Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
    • Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, et al. (2008) Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem 283: 25692-25705.
    • (2008) J Biol Chem , vol.283 , pp. 25692-25705
    • Yalcin, S.1    Zhang, X.2    Luciano, J.P.3    Mungamuri, S.K.4    Marinkovic, D.5
  • 113
    • 43149111604 scopus 로고    scopus 로고
    • Functional interaction between FOXO3a and ATM regulates DNA damage response
    • Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC (2008) Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol 10: 460-467.
    • (2008) Nat Cell Biol , vol.10 , pp. 460-467
    • Tsai, W.B.1    Chung, Y.M.2    Takahashi, Y.3    Xu, Z.4    Hu, M.C.5
  • 114
    • 53749085229 scopus 로고    scopus 로고
    • A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
    • Herrgard MJ, Swainston N, Dobson P, Dunn WB, Arga KY, et al. (2008) A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol 26: 1155-1160.
    • (2008) Nat Biotechnol , vol.26 , pp. 1155-1160
    • Herrgard, M.J.1    Swainston, N.2    Dobson, P.3    Dunn, W.B.4    Arga, K.Y.5
  • 115
    • 33846910173 scopus 로고    scopus 로고
    • Global reconstruction of the human metabolic network based on genomic and bibliomic data
    • Duarte NC, Becker SA, Jamshidi N, Thiele I, Mo ML, et al. (2007) Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci U S A 104: 1777-1782.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 1777-1782
    • Duarte, N.C.1    Becker, S.A.2    Jamshidi, N.3    Thiele, I.4    Mo, M.L.5
  • 116
    • 33747199651 scopus 로고    scopus 로고
    • Challenges to be faced in the reconstruction of metabolic networks from public databases
    • Poolman MG, Bonde BK, Gevorgyan A, Patel HH, Fell DA (2006) Challenges to be faced in the reconstruction of metabolic networks from public databases. Syst Biol (Stevenage) 153: 379-384.
    • (2006) Syst Biol (Stevenage) , vol.153 , pp. 379-384
    • Poolman, M.G.1    Bonde, B.K.2    Gevorgyan, A.3    Patel, H.H.4    Fell, D.A.5
  • 117
    • 52949144612 scopus 로고    scopus 로고
    • Detection of stoichiometric inconsistencies in biomolecular models
    • Gevorgyan A, Poolman MG, Fell DA (2008) Detection of stoichiometric inconsistencies in biomolecular models. Bioinformatics 24: 2245-2251.
    • (2008) Bioinformatics , vol.24 , pp. 2245-2251
    • Gevorgyan, A.1    Poolman, M.G.2    Fell, D.A.3
  • 119
    • 71549133050 scopus 로고    scopus 로고
    • Enzyme kinetics and computational modeling for systems biology
    • Mendes P, Messiha H, Malys N, Hoops S (2009) Enzyme kinetics and computational modeling for systems biology. Methods Enzymol 467: 583-599.
    • (2009) Methods Enzymol , vol.467 , pp. 583-599
    • Mendes, P.1    Messiha, H.2    Malys, N.3    Hoops, S.4
  • 120
    • 70649083250 scopus 로고    scopus 로고
    • Effects of recombination on complex regulatory circuits
    • Martin OC, Wagner A (2009) Effects of recombination on complex regulatory circuits. Genetics 183: 673-684, 671SI-678SI.
    • (2009) Genetics , vol.183 , pp. 673-684
    • Martin, O.C.1    Wagner, A.2
  • 121
    • 0037461036 scopus 로고    scopus 로고
    • Cellerator: Extending a computer algebra system to include biochemical arrows for signal transduction simulations
    • Shapiro BE, Levchenko A, Meyerowitz EM, Wold BJ, Mjolsness ED (2003) Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics 19: 677-678.
    • (2003) Bioinformatics , vol.19 , pp. 677-678
    • Shapiro, B.E.1    Levchenko, A.2    Meyerowitz, E.M.3    Wold, B.J.4    Mjolsness, E.D.5
  • 122
    • 0034961694 scopus 로고    scopus 로고
    • STOCHSIM: Modelling of stochastic biomolecular processes
    • Le Novere N, Shimizu TS (2001) STOCHSIM: modelling of stochastic biomolecular processes. Bioinformatics 17: 575-576.
    • (2001) Bioinformatics , vol.17 , pp. 575-576
    • le Novere, N.1    Shimizu, T.S.2
  • 123
    • 10244219918 scopus 로고    scopus 로고
    • BioNetGen: Software for rule-based modeling of signal transduction based on the interactions of molecular domains
    • Blinov ML, Faeder JR, Goldstein B, Hlavacek WS (2004) BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains. Bioinformatics 20: 3289-3291.
    • (2004) Bioinformatics , vol.20 , pp. 3289-3291
    • Blinov, M.L.1    Faeder, J.R.2    Goldstein, B.3    Hlavacek, W.S.4
  • 125
    • 65649154507 scopus 로고    scopus 로고
    • Rule-based modeling of biochemical systems with BioNetGen
    • Faeder JR, Blinov ML, Hlavacek WS (2009) Rule-based modeling of biochemical systems with BioNetGen. Methods Mol Biol 500: 113-167.
    • (2009) Methods Mol Biol , vol.500 , pp. 113-167
    • Faeder, J.R.1    Blinov, M.L.2    Hlavacek, W.S.3
  • 126
    • 23244465153 scopus 로고    scopus 로고
    • Signaling through receptors and scaffolds: Independent interactions reduce combinatorial complexity
    • Borisov NM, Markevich NI, Hoek JB, Kholodenko BN (2005) Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity. Biophys J 89: 951-966.
    • (2005) Biophys J , vol.89 , pp. 951-966
    • Borisov, N.M.1    Markevich, N.I.2    Hoek, J.B.3    Kholodenko, B.N.4
  • 129
    • 33244481462 scopus 로고    scopus 로고
    • Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
    • Zick Y (2005) Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005: pe4.
    • (2005) Sci STKE , pp. 4
    • Zick, Y.1
  • 130
    • 0034810894 scopus 로고    scopus 로고
    • Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    • Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, et al. (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 15: 2099-2111.
    • (2001) FASEB J , vol.15 , pp. 2099-2111
    • Sesti, G.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Sbraccia, P.5
  • 131
    • 63049091804 scopus 로고    scopus 로고
    • The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2
    • Hanke S, Mann M (2009) The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. Mol Cell Proteomics 8: 519-534.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 519-534
    • Hanke, S.1    Mann, M.2
  • 132
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-1038.
    • (2008) Cell , vol.132 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5
  • 133
    • 73949117703 scopus 로고    scopus 로고
    • Massively regulated genes: The example of TP53
    • Hollstein M, Hainaut P (2010) Massively regulated genes: the example of TP53. J Pathol 220: 164-173.
    • (2010) J Pathol , vol.220 , pp. 164-173
    • Hollstein, M.1    Hainaut, P.2
  • 135
    • 77649208016 scopus 로고    scopus 로고
    • Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage
    • Kim S, Aladjem MI, McFadden GB, Kohn KW (2010) Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage. PLoS Comput Biol 6: e1000665.
    • (2010) PLoS Comput Biol , vol.6
    • Kim, S.1    Aladjem, M.I.2    McFadden, G.B.3    Kohn, K.W.4
  • 136
    • 0034623005 scopus 로고    scopus 로고
    • T-Coffee: A novel method for fast and accurate multiple sequence alignment
    • Notredame C, Higgins DG, Heringa J (2000) T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol 302: 205-217.
    • (2000) J Mol Biol , vol.302 , pp. 205-217
    • Notredame, C.1    Higgins, D.G.2    Heringa, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.