Characterization of mice with targeted deletion of the gene encoding core 2 β1,6-N-acetylglucosaminyltransferase-2

Methods in Enzymology

Volumn 479, Issue C, 2010, Pages 155-172

  Stone, Erica L ^a   Lee, Seung Ho ^b   Ismail, Mohd Nazri ^c   Fukuda, Minoru ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BURNHAM INSTITUTE   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MANNOSE; MUCIN 2; N ACETYLGLUCOSAMINYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; BOOK; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE DELETION; GLYCOSYLATION; INTESTINE MUCOSA PERMEABILITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

MUS;

EID: 77956213445     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(10)79009-1     Document Type: Chapter

References (42)

1. An G., Wei B., Xia B., McDaniel J.M., Ju T., Cummings R.D., Braun J., Xia L. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J. Exp. Med. 2007, 204:1417-1429.
2. Bierhuizen M.F., Fukuda M. Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma largetumor antigen. Proc. Natl. Acad. Sci. USA 1992, 89:9326-9330.
3. Bierhuizen M.F.A., Mattei M.-G., Fukuda M. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a ß-1, 6-N-acetylglucosaminyltransferase gene family. Genes. Dev. 1993, 7:468-478.
4. Brockhausen I. Intestinal candyfloss. Biochem. J. 2004, 384:3-5.
5. Brockington M., Muntoni F. The modulation of skeletal muscle glycosylation as a potential therapeutic intervention in muscular dystrophies. Acta. Myol. 2005, 24:217-221.
6. Clegg D.O., Reda D.J., Harris C.L., Klein M.A., O'Dell J.R., Hooper M.M., Bradley J.D., Bingham C.O., Weisman W.H., Jackson C.G., Lane N.E., Cush J.J., et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N. Engl. J. Med. 2006, 354:795-808.
7. Clement E.M., Godfrey C., Tan J., Brockington M., Torelli S., Feng L., Brown S.C., Jimenez-Mallebrera C., Sewry C.A., Longman C., Mein R., Abbs S., et al. Mild POMGnT1 mutations underlie a novel limb-girdle muscular dystrophy variant. Arch. Neurol. 2008, 65:137-141.
8. Dennis J.W., Nabi I.R., Demetriou M. Metabolism, cell surface organization, and disease. Cell 2009, 139:1229-1241.
9. Ellies L.G., Tsuboi S., Petryniak B., Lowe J.B., Fukuda M., Marth J.D. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 1998, 9:881-890.
10. Furuta G.T., Turner J.R., Taylor C.T., Hershberg R.M., Comerford K., Narravula S., Podolsky D.K., Colgan S.P. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J. Exp. Med. 2001, 193:1027-1034.
11. Garrett W.S., Gordon J.I., Glimcher L.H. Homeostasis and inflammation in the intestine. Cell 2010, 140:859-870.
12. Gauguet J.M., Rosen S.D., Marth J.D., von Andrian U.H. Core 2 branching β1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T lymphocyte homing to peripheral lymph nodes. Blood 2004, 104:4104-4112.
13. Grigorian A., Lee S.U., Tian W., Chen I.J., Gao G., Mendelsohn R., Dennis J.W., Demetriou M. Control of T cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J. Biol. Chem. 2007, 282:20027-20035.
14. Guglieri M., Straub V., Bushby K., Lochmuller H. Limb-girdle muscular dystrophies. Curr. Opin. Neurol. 2008, 21:576-584.
15. Hagisawa S., Ohyama C., Takahashi T., Endoh M., Moriya T., Nakayama J., Arai Y., Fukuda M. Expression of core 2 beta1, 6-N-acetylglucosaminyltransferase facilitates prostate cancer progression. Glycobiology 2005, 15:1016-1024.
16. Hiraoka N., Kawashima H., Petryniak B., Nakayama J., Mitoma J., Marth J.D., Lowe J.B., Fukuda M. Core 2 branching β1, 6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing. J. Biol. Chem. 2004, 279:3058-3067.
17. Ho S.B., Dvorak L.A., Moor R.E., Jacobson A.C., Frey M.R., Corredor J., Polk D.B., Shekels L.L. Cysteine-rich domains of Muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology 2006, 131:1501-1517.
18. Koya D., Dennis J.W., Warren C.E., Takahara N., Schoen F.J., Nishio Y., Nakajima T., Lipes M.A., King G.L. Overexpression of core 2-N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. FASEB J. 1999, 13:2329-2337.
19. Lengeler K.B., Tielker D., Ernst J.F. Protein-O-mannosyltransferases in virulence and development. Cell Mol. Life Sci. 2008, 65:528-544.
20. MacDonald T.T., Monteleone G. Immunity, inflammation, and allergy in the gut. Science 2005, 307:1920-1925.
21. Marth J.D., Grewal P.K. Mammalian glycosylation in immunity. Nat. Rev. Immunol. 2008, 8:874-887.
22. Martin P.T. Congenital muscular dystrophies involving the O-mannose pathway. Curr. Mol. Med. 2007, 7:417-425.
23. Murthy S.N.S., Cooper H.S., Shim H., Shah R.S., Ibrahim S.A., Sedergran D.J. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig. Dis. Sci. 1993, 38:1722-1734.
24. Murthy A.K., Dubose C.N., Banas J.A., Coalson J.J., Arulanandam B.P. Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium-induced colitis. Gastroenterology 2006, 26:1372-1380.
25. Ohtsubo K., Marth J.D. Glycosylation in cellular mechanisms of health and disease. Cell 2006, 126:1-13.
26. Rossi F.M.V., Corbel S.Y., Merzaban J.S., Carlow D.A., Gossens K., Duenas J., So L., Yi L., Ziltener H.J. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 2005, 6:626-634.
27. Schachter H., Brockhausen I. The biosynthesis of branched O-glycans. Symp. Soc. Exp. Biol. 1989, 43:1-26.
28. Schwientek T., Nomoto M., Levery S.B., Merkx G., van Kessel A.G., Bennett E.P., Hollingsworth M.A., Clausen H. Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1, 6-N-acetylglucosaminyltransferase forming core 2 and core 4. J. Biol. Chem. 1999, 274:4504-4512.
29. Schwientek T., Yeh J.C., Levery S.B., Keck B., Merkx G., van Kessel A.G., Fukuda M., Clausen H. Control of O-glycan branch formation: Molecular cloning and characterization of a novel thymus-associated Core 2 β1, 6-N-acteylglucosaminyltransferase. J. Biol. Chem. 2000, 275:11106-11113.
30. Shafi R., Iyer S.P., Ellies L.G., O'Donnell N., Marek K.W., Chui D., Hart G.W., Marth J.D. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc. Natl. Acad. Sci. USA 2000, 97:5735-5739.
31. Shimodaira K., Nakayama J., Nakamura N., Hasebe O., Katsuyama T., Fukuda M. Carcinoma-associated expression of core 2 beta-1, 6-N-acetylglucosaminyltransferase gene in human colorectal cancer: A role of O-glycans in tumor progression. Cancer Res. 1997, 57:5201-5206.
32. Sperandio M., Forlow S.B., Thatte J., Ellies L.G., Marth J.D., Ley K. Differential requirements for core 2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo. J. Immunol. 2001, 167:2268-2274.
33. Stone E.L., Ismail M.N., Lee S.H., Luu Y., Ramirez K., Haslam S.M., Ho S.B., Dell A., Fukuda M., Marth J.D. Glycosyltransferase function in Core 2-type protein O-glycosylation. Mol. Cell. Biol. 2009, 29:3370-3782.
34. Tarp M.A., Clausen H. Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochim. Biophys. Acta 2008, 1780:546-563.
35. Tsuboi S., Fukuda M. Overexpression of branched O-linked oligosaccharides on T cell surface glycoproteins impairs humoral immune responses in transgenic mice. J. Biol. Chem. 1998, 273:30680-30687.
36. Tsuboi S., Fukuda M. Roles of O-linked oligosaccharides in immune responses. Bioessays 2001, 23:46-53.
37. Vaishnava S., Behrendt C.L., Ismail A.S., Eckmann L., Hooper L.V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 2008, 105:20858-20863.
38. van der Sluis M., de Koning B.A.E., de Bruijn A.C.J.M., Velcich A., Meijerink J.P.P., van Goudoever J.B., Buller H.A., Einerhand A.W.C. Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection. Gastroenterology 2006, 131:117-129.
39. Yeh J.C., Ong E., Fukuda M. Molecular cloning and expression of a novel β-1, 6-N-acetylglucosaminyltransferase that forms Core 2, Core 4, and I branches. J. Biol. Chem. 1999, 274:3215-3222.
40. Yeh J.C., Hiraoka N., Petryniak B., Nakayama J., Ellies L.G., Rabuka D., Hindsgaul O., Marth J.D., Lowe J.B., Fukuda M. Novel sulfated lymphocyte homing receptors and their control by a Core 1 extension beta 1,3,-N-acetylglucosaminyltransferase. Cell 2001, 105:957-969.
41. Yoshida A., Kobayashi K., Manya H., Taniguchi K., Kano H., Mizuno M., Inazu T., Mitsuhashi H., Takahashi S., Takeuchi M., Herrmann R., Straub V., et al. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev. Cell 2001, 1:717-724.
42. Zhang W., Betel D., Schachter H. Cloning and expression of a novel UDP-GlcNAc:a-3-D-mannoside b1, 2-N-acetylglucosaminyltransferase I. Biochem. J. 2002, 361:153-162.