Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice

Radiation Research

Volumn 174, Issue 3, 2010, Pages 325-330

  Ware, J H ^a   Sanzari, J ^a   Avery, S ^a   Sayers, C ^a   Krigsfeld, G ^a   Nuth, M ^a   Wan, X S ^a   Rusek, A ^b   Kennedy, A R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEMATOPOIETIC CELL; IRRADIATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON THERAPY; RADIATION DOSE FRACTIONATION; SHAM PROCEDURE; SOLAR RADIATION; ANIMAL; BONE MARROW CELL; INSTITUTE FOR CANCER RESEARCH MOUSE; RADIATION DOSE; RADIATION RESPONSE;

ANIMALS; BONE MARROW CELLS; DOSE FRACTIONATION; MALE; MICE; MICE, INBRED ICR; PROTONS; RADIATION DOSAGE;

EID: 77956211938     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1979.1     Document Type: Article

References (18)

1. C. E. Hellweg and C. Baumstark-Khan, Getting ready for the manned mission to Mars: the astronauts' risk from space radiation. Naturwissenschaften 94, 517-526 (2007).
2. J. W. Wilson, F. A. Cucinotta, J. L. Shinn, L. C. Simonsen, R. R. Dubey, W. R. Jordan, T. D. Jones, C. K. Chang and M. Y. Kim, Shielding from solar particle event exposures in deep space. Radiat. Res. 30, 361-382 (1999).
3. D. F. Smart and M. A. Shea, The local time dependence of the anisotropic solar cosmic ray flux. Adv. Space Res. 32, 109-114 (2003).
4. K. L. Koenig, R. E. Goans, R. J. Hatchett, F. A. Mettler, Jr., T. A. Schumacher, E. K. Noji and D. G. Jarrett, Medical treatment of radiological casualties: current concepts. Ann. Emerg. Med. 45, 643-652 (2005).
5. C. N. Coleman, W. F. Blakely, J. R. Fike, T. J. MacVittie, N. F. Metting, J. B. Mitchell, J. E. Moulder, R. J. Preston, T. M. Seed and R. S. Wong, Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiat. Res. 159, 812-834 (2003).
6. F. A. Mettler, Jr. and G. L. Voelz, Major radiation exposure\what to expect and how to respond. N. Engl. J. Med. 346, 1554-1561 (2002).
7. F. Herodin and M. Drouet, Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 33, 1071-1080 (2005).
8. C. Wambi, J. Sanzari, M. Nuth, J. Davis, Y-H. Ko, C. M. Sayers, M. Baran, J. H. Ware and A. R. Kennedy, Dietary antioxidants protect hematopoietic cells and improve animal survival following total-body irradiation. Radiat. Res. 169, 384-396 (2008).
9. C. O. Wambi, J. K. Sanzari, C. M. Sayers, M. Nuth, Z. Zhou, J. Davis, N. Finnberg, J. S. Lewis-Wambi, J. H. Ware and A. R. Kennedy, Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival. Radiat. Res. 172, 175-186 (2009).
10. R. G. Evans, C. L. Wheatley and J. R. Nielsen, Modification of radiation-induced damage to bone marrow stem cells by dose rate, dose fractionation, and prior exposure to cytoxan as judged by the survival of CFUs: application to bone marrow transplantation (BMT). Int. J. Radiat. Oncol. Biol. Phys. 14, 491-495 (1988).
11. M. J. Pecaut, D. S. Gridley, A. L. Smith and G. A. Nelson, Dose and dose rate effects of whole-body proton-irradiation on lymphocyte blastogenesis and hematological variables: part II. Immunol. Lett. 80, 67-73 (2002).
12. D. S. Gridley, M. J. Pecaut, R. Dutta-Roy and G. A. Nelson, Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I. Immunol. Lett. 80, 55-66 (2002).
13. R. van Os, H. D. Thames, A. W. Konings and J. D. Down, Radiation dose-fractionation and dose-rate relationships for long-term repopulating hemopoietic stem cells in a murine bone marrow transplant model. Radiat. Res. 136, 118-125 (1993).
14. E. J. Ainsworth, S. M. Afzal, D. A. Crouse, W. R. Hanson and R. J. M. Fry, Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures. Adv. Space Res. 9, 299-313 (1989).
15. M. Yonezawa, Induction of radio-resistance by low dose X-irradiation. Yakugaku Zasshi J. Pharm. Soc. Jpn. 126, 833-840 (2006).
16. J. B. Storer, P. S. Harris, J. E. Furchner and W. H. Lang-ham, The relative biological effectiveness of various ionizing radiations in mammalian systems. Radiat. Res. 6, 188-288 (1952).
17. NCRP, Guidance on Radiation Received in Space Activities. Report No. 98, National Council on Radiation Protection and Measurements, Bethesda, MD, 1989.
18. NCRP, Information Needed to Make Radiation Protection Recommendations for Space Missions beyond Low-Earth Orbit. Report No. 153, National Council on Radiation Protection and Measurements, Bethesda, MD, 2006.