Research Characterization of the GXXXG motif in the first transmembrane segment of Japanese encephalitis virus precursor membrane (prM) protein

Journal of Biomedical Science

Volumn 17, Issue , 2010, Pages

  Lin, Ying Ju ^a   Peng, Jia Guan ^b   Wu, Suh Chin ^b,c  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PRM PROTEIN, FLAVIVIRUS; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ARMYWORM; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; FLAVIVIRUS; GENETICS; JAPANESE ENCEPHALITIS VIRUS; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; VIRUS ASSEMBLY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DIMERIZATION; ENCEPHALITIS VIRUS, JAPANESE; FLAVIVIRUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPODOPTERA; VIRAL ENVELOPE PROTEINS; VIRUS ASSEMBLY;

EID: 77956210935     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-17-39     Document Type: Article

References (35)

1. Burke D: Flaviviruses. Fields virology 4th edition. 2001:1043-1125.
2. Linderbach B: Flaviviridae: the viruses and their replication. Fields virology, Lippincott-Raven, Philadelphia, Pa 4th edition. 2001:991-1041.
3. Russel P: The Togaviruses. Academic Press, New York, NY; 1980:503-529.
4. Allison SL, Stadler K, Mandl CW, Kunz C, Heinz FX: Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form. J Virol 1995, 69:5816-5820.
5. Konishi E, Fujii A: Dengue type 2 virus subviral extracellular particles produced by a stably transfected mammalian cell line and their evaluation for a subunit vaccine. Vaccine 2002, 20:1058-1067.
6. Konishi E, Fujii A, Mason PW: Generation and characterization of a mammalian cell line continuously expressing Japanese encephalitis virus subviral particles. J Virol 2001, 75:2204-2212.
7. Lin YJ, Wu SC: Histidine at residue 99 and the transmembrane region of the precursor membrane prM protein are important for the prM-E heterodimeric complex formation of Japanese encephalitis virus. J Virol 2005, 79:8535-8544.
8. Kroeger MA, McMinn PC: Murray Valley encephalitis virus recombinant subviral particles protect mice from lethal challenge with virulent wild-type virus. Arch Virol 2002, 147:1155-1172.
9. Purdy DE, Noga AJ, Chang GJ: Noninfectious recombinant antigen for detection of St. Louis encephalitis virus-specific antibodies in serum by enzyme-linked immunosorbent assay. J Clin Microbiol 2004, 42:4709-4717.
10. Davis BS, Chang GJ, Cropp B, Roehrig JT, Martin DA, Mitchell CJ, Bowen R, Bunning ML: West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 2001, 75:4040-4047.
11. Mukhopadhyay S, Kuhn RJ, Rossmann MG: A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 2005, 3:13-22.
12. Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ: Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol 2003, 10:907-912.
13. Allison SL, Stiasny K, Stadler K, Mandl CW, Heinz FX: Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E. J Virol 1999, 73:5605-5612.
14. Op De Beeck A, Molenkamp R, Caron M, Younes Ben A, Bredenbeek P, Dubuisson J: Role of the transmembrane domains of prM and E proteins in the formation of yellow fever virus envelope. J Virol 2003, 77:813-820.
15. Chang GJ, Hunt AR, Holmes DA, Springfield T, Chiueh TS, Roehrig JT, Gubler DJ: Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus. Virology 2003, 306:170-180.
16. Purdy DE, Chang GJ: Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein. Virology 2005, 333:239-250.
17. Orlinger KK, Hoenninger VM, Kofler RM, Mandl CW: Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly. J Virol 2006, 80:12197-12208.
18. Lin CW, Wu SC: A functional epitope determinant on domain III of the Japanese encephalitis virus envelope protein interacted with neutralizing-antibody combining sites. J Virol 2003, 77:2600-2606.
19. Wu SC, Lian WC, Hsu LC, Liau MY: Japanese encephalitis virus antigenic variants with characteristic differences in neutralization resistance and mouse virulence. Virus Res 1997, 51:173-181.
20. Wu SC, Lee SC: Complete nucleotide sequence and cell-line multiplication pattern of the attenuated variant CH2195LA of Japanese encephalitis virus. Virus Res 2001, 73:91-102.
21. Braun P, Persson B, Kaback HR, von Heijne G: Alanine insertion scanning mutagenesis of lactose permease transmembrane helices. J Biol Chem 1997, 272:29566-29571.
22. Mingarro I, Whitley P, Lemmon MA, von Heijne G: Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins. Protein Sci 1996, 5:1339-1341.
23. Ulmschneider MB, Sansom MS: Amino acid distributions in integral membrane protein structures. Biochim Biophys Acta 2001, 1512:1-14.
24. Op De Beeck A, Montserret R, Duvet S, Cocquerel L, Cacan R, Barberot B, Le Maire M, Penin F, Dubuisson J: The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization. J Biol Chem 2000, 275:31428-31437.
25. Altmann F, Staudacher E, Wilson IB, Marz L: Insect cells as hosts for the expression of recombinant glycoproteins. Glycoconj J 1999, 16:109-123.
26. Pryor MJ, Azzola L, Wright PJ, Davidson AD: Histidine 39 in the dengue virus type 2 M protein has an important role in virus assembly. J Gen Virol 2004, 85:3627-3636.
27. Yoshii K, Konno A, Goto A, Nio J, Obara M, Ueki T, Hayasaka D, Mizutani T, Kariwa H, Takashima I: Single point mutation in tick-borne encephalitis virus prM protein induces a reduction of virus particle secretion. J Gen Virol 2004, 85:3049-3058.
28. Ferlenghi I, Clarke M, Ruttan T, Allison SL, Schalich J, Heinz FX, Harrison SC, Rey FA, Fuller SD: Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Mol Cell 2001, 7:593-602.
29. Stadler K, Allison SL, Schalich J, Heinz FX: Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 1997, 71:8475-8481.
30. Sjoberg M, Garoff H: Interactions between the transmembrane segments of the alphavirus E1 and E2 proteins play a role in virus budding and fusion. J Virol 2003, 77:3441-3450.
31. Ciczora Y, Callens N, Penin F, Pecheur EI, Dubuisson J: Transmembrane domains of hepatitis C virus envelope glycoproteins: residues involved in E1E2 heterodimerization and involvement of these domains in virus entry. J Virol 2007, 81:2372-2381.
32. Liao M, Kielian M: The conserved glycine residues in the transmembrane domain of the Semliki Forest virus fusion protein are not required for assembly and fusion. Virology 2005, 332:430-437.
33. Cocquerel L, Wychowski C, Minner F, Penin F, Dubuisson J: Charged residues in the transmembrane domains of hepatitis C virus glycoproteins play a major role in the processing, subcellular localization, and assembly of these envelope proteins. J Virol 2000, 74:3623-3633.
34. Ronecker S, Zimmer G, Herrler G, Greiser-Wilke I, Grummer B: Formation of bovine viral diarrhea virus E1-E2 heterodimers is essential for virus entry and depends on charged residues in the transmembrane domains. J Gen Virol 2008, 89:2114-2121.
35. Senes A, Gerstein M, Engelman DM: Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J Mol Biol 2000, 296:921-936.