The mechanism and control of neuropathic pain

Clinical Neurology

Volumn 49, Issue 11, 2009, Pages 779-782

  Inoue, Kazuhide ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

ATP receptors; Microglia; Neuropathic pain

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GAMMA INTERFERON; MORPHINE; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; 4 AMINOBUTYRIC ACID; CHLORINE; PURINERGIC P2 RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL ACTIVATION; CELL COMMUNICATION; CONFERENCE PAPER; MICROGLIA; MOUSE; NERVE CELL EXCITABILITY; NERVE INJURY; NEUROMODULATION; NEUROPATHIC PAIN; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR UPREGULATION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; HUMAN; ION TRANSPORT; METABOLISM; NEURALGIA; PHYSIOLOGY; REVIEW; SECRETION; SPINAL CORD; STIMULATION; UPREGULATION;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CHLORINE; GAMMA-AMINOBUTYRIC ACID; HUMANS; INTERFERON-GAMMA; ION PUMPS; MICROGLIA; NEURALGIA; PHYSICAL STIMULATION; RECEPTORS, PURINERGIC P2; SPINAL CORD; UP-REGULATION;

EID: 77956197206     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.49.779     Document Type: Conference Paper

References (7)

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2. Coull JA, Beggs S, Boudreau D, et al: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 2005; 438: 1017-1021 (Pubitemid 43093974)
3. Trang T, Beggs S, Wan X, et al: P2X4-Peceptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation. J Neurosci 2009; 29: 3518-3528
4. Tsuda M, Toyomitsu E, Komatsu T, et al: Fibronectin/integrin system is involved in P2X (4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury. Glia 2008; 56: 579-585
5. Tsuda M, Tozaki-Saitoh H, Masuda T, et al: Lyn tyrosine kinase is required for P2X (4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 2008; 56: 50-58
6. Tozaki-Saitoh H, Tsuda M, Miyata H, et al: P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J Neurosci 2008; 28: 4949-4956
7. Tsuda M, Masuda T, Kitano J, et al: IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain. Pro Natl Acad Sci USA 2009; 106: 8032-8037