Core 3-derived O-glycans are essential for intestinal mucus barrier function

Methods in Enzymology

Volumn 479, Issue C, 2010, Pages 123-141

  Xia, Lijun ^a,b,c  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; GLYCAN; MUCIN; MUCIN 2; N ACETYLGLUCOSAMINYLTRANSFERASE;

ANIMAL TISSUE; BOOK; COLITIS; COLON; DISEASE PREDISPOSITION; ENZYME ACTIVITY; GENE DISRUPTION; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION;

MUS;

EID: 77956196001     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(10)79007-8     Document Type: Chapter

References (27)

1. Araki A., Kanai T., Ishikura T., Makita S., Uraushihara K., Iiyama R., Totsuka T., Takeda K., Akira S., Watanabe M. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J. Gastroenterol. 2005, 40:16-23.
2. Brockhausen I., Kuhns W. Glycoproteins and Human Disease 1997, R. G. Landes Company, Austin, TX.
3. Clayburgh D.R., Barrett T.A., Tang Y., Meddings J.B., Van Eldik L.J., Watterson D.M., Clarke L.L., Mrsny R.J., Turner J.R. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J. Clin. Invest. 2005, 115:2702-2715.
4. Corfield A.P., Carroll D., Myerscough N., Probert C.S. Mucins in the gastrointestinal tract in health and disease. Front. Biosci. 2001, 6:D1321-D1357.
5. Corless C.E., Guiver M., Borrow R., Edwards-Jones V., Kaczmarski E.B., Fox A.J. Contamination and sensitivity issues with a real-time universal 16S rRNA PCR. J. Clin. Microbiol. 2000, 38:1747-1752.
6. Elson C.O., Sartor R.B., Targan S.R., Sandborn W.J. Challenges in IBD Research: Updating the scientific agendas. Inflamm. Bowel Dis. 2003, 9:137-153.
7. Iwai T., Inaba N., Naundorf A., Zhang Y., Gotoh M., Iwasaki H., Kudo T., Togayachi A., Ishizuka Y., Nakanishi H., et al. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1, 3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. J. Biol. Chem. 2002, 277:12802-12809.
8. Iwai T., Kudo T., Kawamoto R., Kubota T., Togayachi A., Hiruma T., Okada T., Kawamoto T., Morozumi K., Narimatsu H. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. Proc. Natl. Acad. Sci. USA 2005, 102:4572-4577.
9. Kabashima K., Saji T., Murata T., Nagamachi M., Matsuoka T., Segi E., Tsuboi K., Sugimoto Y., Kobayashi T., Miyachi Y., et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J. Clin. Invest. 2002, 109:883-893.
10. Macdonald T.T., Monteleone G. Immunity, inflammation, and allergy in the gut. Science 2005, 307:1920-1925.
11. Macfarlane S., Woodmansey E.J., Macfarlane G.T. Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system. Appl. Environ. Microbiol. 2005, 71:7483-7492.
12. Macpherson A.J., Smith K. Mesenteric lymph nodes at the center of immune anatomy. J. Exp. Med. 2006, 203:497-500.
13. Morteau O., Morham S.G., Sellon R., Dieleman L.A., Langenbach R., Smithies O., Sartor R.B. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J. Clin. Invest. 2000, 105:469-478.
14. Nadkarni M.A., Martin F.E., Jacques N.A., Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology (Reading, England) 2002, 148:257-266.
15. Ott S.J., Musfeldt M., Ullmann U., Hampe J., Schreiber S. Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora. J. Clin. Microbiol. 2004, 42:2566-2572.
16. Podolsky D.K., Isselbacher K.J. Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis. Gastroenterology 1984, 87:991-998.
17. Ponda P.P., Mayer L. Mucosal epithelium in health and disease. Curr. Mol. Med. 2005, 5:549-556.
18. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
19. -/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289:G153-G162.
20. Rhodes J.M. Unifying hypothesis for inflammatory bowel disease and associated colon cancer: Sticking the pieces together with sugar. Lancet 1996, 347:40-44.
21. Rhodes J.M. Colonic mucus and ulcerative colitis. Gut 1997, 40:807-808.
22. Stevceva L., Pavli P., Husband A.J., Doe W.F. The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it. BMC Clin. Pathol. 2001, 1:3.
23. Turnbull E.L., Yrlid U., Jenkins C.D., Macpherson G.G. Intestinal dendritic cell subsets: Differential effects of systemic TLR4 stimulation on migratory fate and activation in vivo. J. Immunol. 2005, 174:1374-1384.
24. Van der Heijden P.J., Stok W. Improved procedure for the isolation of functionally active lymphoid cells from the murine intestine. J. Immunol. Methods 1987, 103:161-167.
25. Wei B., Velazquez P., Turovskaya O., Spricher K., Aranda R., Kronenberg M., Birnbaumer L., Braun J. Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc. Natl. Acad. Sci. USA 2005, 102:2010-2015.
26. Xia B., Royall J.A., Damera G., Sachdev G.P., Cummings R.D. Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis. Glycobiology 2005, 15:747-775.
27. Xia L., Ju T., Westmuckett A., An G., Ivanciu L., McDaniel J.M., Lupu F., Cummings R.D., McEver R.P. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J. Cell Biol. 2004, 164:451-459.