The Polonium-210 Public Health Assessment: The Need for Medical Toxicology Expertise in Radiation Terrorism Events

Journal of Medical Toxicology

Volumn 6, Issue 3, 2010, Pages 355-359

  Nemhauser, Jeffrey B ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLONIUM;

ARTICLE; CHEMICAL ANALYSIS; ENVIRONMENTAL HEALTH; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL MONITORING; ENVIRONMENTAL PROTECTION; HUMAN; INTOXICATION; PROPHYLAXIS; PUBLIC HEALTH; RADIATION; RADIOACTIVE CONTAMINATION; TERRORISM; TOXICOLOGY; RADIATION INJURIES; RADIATION MONITORING;

HUMANS; POLONIUM; PUBLIC HEALTH; RADIATION INJURIES; RADIATION MONITORING; TERRORISM; TOXICOLOGY;

EID: 77956188840     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-010-0090-x     Document Type: Article

References (26)

1. Stannard JN (1964) Distribution and excretion of polonium-210. I. Comparison of oral and intravenous routes in the rat. Radiat Res Suppl 5: 49-59.
2. Morrow PE, Smith FA, Dellarosa RJ, Casarett LJ, Stannard JN (1964) Distribution and excretion of polonium-210. II. The early fate in cats. Radiat Res Suppl 5: 60-66.
3. Stannard JN (1964) Distribution and excretion of polonium-210. III. Long-term retention and distribution in the rat. Radiat Res Suppl 5: 67-79.
4. Stannard JN, Baxter RC (1964) Distribution and excretion of polonium-210. IV. On a multiple-dose regimen. Radiat Res Suppl 5: 80-92.
5. Stannard JN, Casarett GW (1964) Concluding comments on biological effects of alpha-particle emitters in soft tissue as exemplified by experiments with polonium 210. Radiat Res Suppl 5: 398-434.
6. Hursh JB (1951) The effect of BAL on the excretion and tissue distribution of polonium in rats. J Pharmacol Exp Ther 103(4): 450-459.
7. Hursh JB (1952) Effect of BAL on survival of rats after lethal doses of polonium. Proc Soc Exp Biol Med 79(2): 210-212.
8. Aposhian HV, Dart RC, Aposhian MM, Dawson BV (1987) Tissue decorporation in rats by DMPA. Res Commun Chem Pathol Pharmacol 58(2): 157-171.
9. Bogdan GM, Aposhian HV (1990) N-(2, 3-dimercaptopropyl)phthalamidic acid (DMPA) increases polonium-210 excretion. Biol Metals 3: 232-236.
10. Rencová J, Svoboda V, Holuša R, Volf V, Jones MM, Singh PK (1997) Reduction of subacute lethal radiotoxicity of polonium-210 in rats by chelating agents. Int J Radiat Biol 72(3): 341-348.
11. Rencová J, Volf V, Jones MM, Singh PK (2000) Mobilization and detoxification of polonium-210 in rats by 2, 3-dimercaptosuccinic acid and its derivatives. Int J Radiat Biol 76(10): 1409-1415.
12. Health Risks of Radon and Other Internally Deposited Alpha-Emitters: BEIR IV (1988). Chapter 3: Polonium. http://www. nap. edu/openbook/0309037972/html/159. html, Accessed February 23, 2010.
13. Stannard JN (1988) Chapter 4: polonium and thorium. In: Radioactivity and health: a history. Office of Scientific and Technical Information, Springfield, VA.
14. International Agency for Research on Cancer (2001) Ionizing radiation, part 2: Some internally deposited radionuclides, vol 78. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. International Agency for Research on Cancer, Lyon, France.
15. Leggett RW, Eckerman KF (2001) A systemic biokinetic model for polonium. Sci Total Environ 275: 109-125.
16. Chin FKC (2007) Scenario of a dirty bomb in an urban environment and acute management of radiation poisoning and injuries. Singapore Med J 48(10): 950-957.
17. Harrison J, Leggett R, Lloyd D, Phipps A, Scott B (2007) Polonium-210 as a poison. J Radiol Prot 27: 17-40.
18. Le M (2007) Polonium 210, exposed. J Med Toxicol 3(2): 82-84.
19. Scott BR (2007) Health risk evaluations for ingestion exposure of humans to polonium-210. Dose Response 5(2): 94-122.
20. Stather JW (2007) The polonium-210 poisoning in London. J Radiol Prot 27(1): 1-3.
21. 210Po. J Occup Environ Med 50(8): 916-923.
22. Brosh-Nissimov T, Havkin O, Davidovitch N, Poles L, Shapira C (2008) Suspected radioactive contamination: evaluation of 45 Israeli citizens potentially exposed to polonium-210 in London. Isr Med Assoc J 10(2): 99-103.
23. Cornett J, Tracy B, Kramer G, Whyte J, Moodie G, Auclair JP, Thomson D (2009) Polonium-210: lessons learned from the contamination of individual Canadians. Radiat Prot Dosimetry 134(3-4): 164-166.
24. McFee RB, Leikin J (2009) Death by polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko. Semin Diagn Pathol 26(1): 61-67.
25. Jefferson RD, Goans RE, Blain PG, Thomas SHL (2009) Diagnosis and treatment of polonium poisoning. Clin Tox 47: 379-392.
26. Rubin GJ, Page L, Morgan O, Pinder RJ, Riley P, Hatch S, Maguire H, Catchpole M, Simpson J, Wessely S (2007) Public information needs after the poisoning of Alexander Litvinenko with polonium-210 in London: cross sectional telephone survey and qualitative analysis. BMJ 335(7630): 1143.