Pathological complete response: Still a relevant endpoint in rectal cancer?

The Lancet Oncology

Volumn 11, Issue 9, 2010, Pages 807-808

  Chua, Yu Jo ^a  

^a CANBERRA HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; CYTOTOXIC AGENT; FLUOROPYRIMIDINE;

ADVANCED CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; DISTANT METASTASIS; DRUG EFFICACY; HISTOPATHOLOGY; HUMAN; LONG TERM CARE; MICROMETASTASIS; MONOTHERAPY; MORBIDITY; NOTE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATHOLOGICAL COMPLETE RESPONSE; PERIOPERATIVE PERIOD; PREOPERATIVE CARE; PRIORITY JOURNAL; QUALITY CONTROL; RECTUM CANCER; RECTUM SURGERY; RECURRENCE RISK; RISK REDUCTION; SYSTEMIC THERAPY; TREATMENT RESPONSE; ABDOMINAL SURGERY; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; CLINICAL TRIAL (TOPIC); MULTIMODALITY CANCER THERAPY; PATHOLOGY; RECTAL NEOPLASMS; TREATMENT OUTCOME;

CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; DIGESTIVE SYSTEM SURGICAL PROCEDURES; HUMANS; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 77956185719     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(10)70189-3     Document Type: Note

References (5)

1. Chua YJ, Barbachano Y, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 2010, 11:241-248.
2. Aschele C, Pinto C, Cordio S, et al. Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: pathologic response analysis of the Studio Terapia Adiuvante Retto (STAR)-01 randomized phase III trial. Proc Am Soc Clin Oncol 2009, 27. CRA2008 (abstr).
3. Gerard JP, Azria D, Gourgou-Bourgade S, et al. Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol 2010, 28:1638-1644.
4. Maas M, Nelemans PJ, Valentini V, et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 2010, published online Aug 9. 10.1016/S1470-2045(10)70172-8.
5. Quirke P, Steele R, Monson J, et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 2009, 373:821-828. on behalf of the MRC CR07/NCIC-CTG CO16 trial investigatorsthe NCRI colorectal cancer study group.