Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats

European Journal of Pharmacology

Volumn 645, Issue 1-3, 2010, Pages 177-184

  Kannappan, Sriramajayam ^a   Palanisamy, Nallasamy ^a   Anuradha, Carani Venkatraman ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidant; Flavonoid; L NAME; Naringenin; Nitric oxide; Nitroxidative stress

Indexed keywords

2,4 DINITROPHENOL; 3 NITROTYROSINE; 4 HYDROXYNONENAL; CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FRUCTOSE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INSULIN; LACTATE DEHYDROGENASE; N(G) NITROARGININE METHYL ESTER; NARINGENIN; NITRIC OXIDE; NITRITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; INSULIN SENSITIVITY; LIPID PEROXIDATION; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

2,4-DINITROPHENOL; ALDEHYDES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD GLUCOSE; DIET; FLAVANONES; FRUCTOSE; HEPATOCYTES; INSULIN; INSULIN RESISTANCE; LIVER; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RATS; RATS, WISTAR; TYROSINE;

EID: 77956184900     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.07.015     Document Type: Article

References (50)

1. Adeneye A.A., Adeyemi O.O. Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes. J. Ethnopharmacol. 2009, 126:238-243.
2. Anitha Nandhini A.T., Balakrishnan S.D., Anuradha C.V. Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats. J. Biol. Mol. Biol. Biophys. 2002, 6:129-133.
3. Baker H.O., Fuanko B., De Angelis S., Feingold F. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr. Rep. Int. 1980, 21:531-536.
4. Basciano H., Federico L., Adeli K. Fructose, insulin resistance and metabolic dyslipidemia. Nutr. Metab. (Lond.) 2005, 2:1-14.
5. Cook J.A., Kim S.Y., Teague D. Convenient colorimetric and fluorometric assays for S-Nitrosothiols. Anal. Biochem. 1996, 238:150-158.
6. Damiano P., Cavallero S., Mayer M., Roson M.I., de la Riva I., Fernández B., Puyo A.M. Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension. Blood Press. 2002, 11:345-351.
7. Datta K., Sinha S., Chattopadhyay P. Reactive oxygen species in health and diseases. Natl. Med. J. India 2000, 13:304-310.
8. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
9. Gao K., Henning S.M., Niu Y., Youssefian A.A., Seeram N.P., Xu A., Heber D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. J. Nutr. Biochem. 2006, 17:89-95.
10. Guenther B. Free fatty acids as target for therapy. Curr. Opin. Endocrinol. Diab. 2004, 11:258-263.
11. Hämäläinen M., Nieminen R., Vuorela P., Heinonen M., Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat. Inflamm. 2007, 2007:456-473.
12. He S., Rehman H., Wright G.L., Zhong Z. Inhibition of inducible nitric oxide synthase prevents mitochondrial damage and improves survival of steatotic partial liver grafts. Transplantation 2010, 89:291-298.
13. Heo H.J., Kim D.O., Shin S.C., Kim M.J., Kim B.G., Shin D.H. Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection. J. Agric. Food Chem. 2004, 52:1520-1525.
14. Imai K., Nakachi K. Cross sectional study of effect of drinking green tea on cardiovascular and liver diseases. Br. Med. J. 1995, 310:693-696.
15. Ischiropoulos H. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch. Biochem. Biophys. 1998, 356:1-11.
16. Jeon S.M., Kim H.K., Kim H.J., Do G.M., Jeong T.S., Park Y.B., Choi M.S. Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats. Transl. Res. 2007, 149:15-21.
17. Jiang Z.Y., Hunt J.V., Wolf S.P. Detection of lipid hydroperoxides using the FOX method. Anal. Biochem. 1992, 202:384-389.
18. Jurgens H., Haass W., Castaneda T.R., Schurmann A., Koebnick C., Dombrowski F., Otto B., Nawrocki A.R., Scherer P.E., Spranger J., Ristow M., Joost H., Havel P.J., Tschop M.H. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes. Res. 2005, 13:1146-1156.
19. Kaneki M., Shimizu N., Yamada D., Chang K. Nitrosative stress and pathogenesis of insulin resistance. Antioxid. Redox Signal. 2007, 9:319-329.
20. Kaneto H., Fujii J., Myint T., Miyazawa N., Islam K.N., Kawasaki Y., Suzuki K., Nakamura M., Tatsumi H., Yamasaki Y., Taniguchi N. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochem. J. 1996, 320:855-863.
21. Kannappan S., Anuradha C.V. Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome. Eur. J. Nutr. 2010, 49:101-109.
22. Kumar M.S., Unnikrishnan M.K., Patra S., Murthy K., Srinivasan K.K. Naringin and naringenin inhibit nitrite-induced methemoglobin formation. Pharmazie 2003, 58:564-566.
23. Levi B., Werman M.J. Fructose triggers DNA modification and damage in an Escherichia coli plasmid. J. Nutr. Biochem. 2001, 12:235-241.
24. Levi B., Werman M.J. Fructose and related phosphate derivatives impose DNA damage and apoptosis in L5178Y mouse lymphoma cells. J. Nutr. Biochem. 2003, 14:49-60.
25. Levine R.L., Garland G., Oliver C.N., Amici A., Climent I., Lenz A.G., Ahn B.W., Shaltiel S., Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Meth. Enzymol. 1990, 186:464-478.
26. Liu L., Xu D.M., Cheng Y.Y. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. J. Agric. Food Chem. 2008, 56:824-829.
27. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
28. Mathews D.R., Hosker J.P., Rudenkl A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
29. Mullokandov E.A., Franklin W.A., Brownlee M. DNA damage by the glycation products of glyceraldehyde 3-phosphate and lysine. Diabetologia 1994, 37:145-149.
30. Mulvihill E.E., Allister E.M., Sutherland B.G., Telford D.E., Sawyez C.G., Edwards J.Y., Markle J.M., Hegele R.A., Huff M.W. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 2009, 58:2198-2210.
31. Niehaus W.G., Samuelsson S. Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation. Eur. J. Biochem. 1968, 6:126-130.
32. Oda A., Bannai C., Yamoka T., Kotari T., Matsushima T., Yamashita K. Inactivation of Cu, Zn-superoxide dismutase by in vitro glycosylation in erythrocytes of diabetic patients. Horm. Metab. Res. 1994, 26:1-4.
33. Ortiz-Andrade R.R., Sánchez-Salgado J.C., Navarrete-Vázquez G., Webster S.P., Binnie M., García-Jiménez S., León-Rivera I., Cigarroa-Vázquez P., Villalobos-Molina R., Estrada-Soto S. Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diab. Obes. Metab. 2008, 10:1097-1104.
34. Oshida Y., Tachi Y., Morishita Y., Kitakoshi K., Fuku N., Han Y.Q., Ohsawa I., Sato Y. Nitric oxide decreases insulin resistance induced by high-fructose feeding. Horm. Metab. Res. 2000, 32:339-342.
35. Rajasekar P., Kaviarasan S., Anuradha C.V. l-Carnitine administration prevents oxidative stress in high fructose-fed insulin resistant rats. Diabetol. Croat. 2005, 34:21-28.
36. Ratty A.K., Das N.P. Effects of flavonoids on nonenzymatic lipid peroxidation: structure-activity relationship. Biochem. Med. Metab. Biol. 1988, 39:69-79.
37. Rock E., Astier C., Lab C., Malpuech C. Magnesium deficiency in rats induces a rise in plasma nitric oxide. Magnes. Res. 1995, 8:237-242.
38. Roe J.H., Kuether C.A. Detection of ascorbic acid in whole blood and urine through the 2, 4-DNPH derivative of dehydroascorbic acid. J. Biol. Chem. 1943, 147:399-407.
39. Rutledge A.C., Adeli K. Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. Nutr. Rev. 2007, 65:S13-S23.
40. Saija A., Scalese M., Lanza M., Marzullo D., Bonina F., Castelli F. Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic. Biol. Med. 1995, 19:481-486.
41. Seglen P.O. Preparation of isolated rat liver cells. Meth. Cell. Biol. 1976, 13:29.
42. Shinozaki K., Ayajiki K., Nishio Y., Sugaya T., Kashiwagi A., Okamura T. Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance. Hypertension 2004, 43:255-262.
43. Sumiyabanu M.S., Palanisamy N., Pooranaperundevi M., Viswanathan P., Anuradha C.V. Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance. J. Diab. 2009, 278-287.
44. Thirunavukkarasu V., Anitha Nandhini A.T., Anuradha C.V. Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose fed rats. J. Comp. Physiol. B 2004, 174:587-592.
45. Tran L.T., Yuen V.G., McNeill J.H. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol. Cell. Biochem. 2009, 332:145-159.
46. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res. 2003, 42:318-343.
47. Varley H. Practical Clinical Biochemistry 2004, 230-273. CBS Publishers and distributors, New Delhi, India. 4th ed.
48. Wilcox L.J., Borradaile N.M., Huff M.W. Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc. Drug Rev. 1999, 17:160-178.
49. Wolff S.P., Dean R.T. Glucose autoxidation and protein modification. The potential role of autoxidative glycosylation in diabetes. Biochem. J. 1987, 245:243-250.
50. Zhao C.X., Xu X., Cui Y., Wang P., Wei X., Yang S., Edin M.L., Zeldin D.C., Wang D.W. Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. J. Pharmacol. Exp. Ther. 2009, 328:610-620.