Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas

Child's Nervous System

Volumn 26, Issue 8, 2010, Pages 1051-1056

  Buttarelli, Francesca R ^a   Massimino, Maura ^b   Antonelli, Manila ^c   Lauriola, Libero ^d   Nozza, Paolo ^e   Donofrio, Vittoria ^g   Arcella, Antonella ^f   Oliva, Maria A ^f   Di Rocco, Concezio ^d   Giangaspero, Felice ^c,f,h  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e G GASLINI INSTITUTE   (Italy)

^f IRCCS NEUROMED   (Italy)

^g SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^h POLICLINICO UMBERTO I   (Italy)

Author keywords

Expression; Methylation; MGMT; Pediatric glioma; Survival

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADOLESCENT; ARTICLE; CANCER GRADING; CHILD; CLINICAL ARTICLE; DNA METHYLATION; FEMALE; GENE OVEREXPRESSION; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROMOTER REGION; PROTEIN EXPRESSION; SURVIVAL TIME;

ADOLESCENT; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; KAPLAN-MEIERS ESTIMATE; MALE; PROGNOSIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 77956183827     PISSN: 02567040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00381-010-1191-1     Document Type: Article

References (15)

1. P Kaatsch CH Rickert J Kühl J Schüz J Michaelis 2001 Population-based epidemiologic data on brain tumors in German children Cancer 15 3155 3164 10.1002/1097-0142(20011215)92:12<3155::AID-CNCR10158>3.0.CO;2-C
2. T Haque D Faury S Albrecht E Lopez-Aguilar P Hauser M Garami Z Hanzély L Bognár RF Del Maestro J Atkinson A Nantel N Jabado 2007 Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma Clin Cancer Res 13 6284 6292 10.1158/1078-0432.CCR-07- 0525 1:CAS:528:DC%2BD2sXht1Cgtb7E 17975139
3. CH Rickert R Sträter P Kaatsch H Wassmann H Jürgens B Dockhorn-Dworniczak W Paulus 2001 Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases Am J Pathol 158 1525 1532 1:STN:280:DC%2BD3M3gvFKnsw%3D%3D 11290570
4. V Suri P Das A Jain MC Sharma SA Borkar A Suri D Gupta C Sarkar 2009 Pediatric glioblastomas: a histopathological and molecular genetic study Neuro Oncol 11 274 280 10.1215/15228517-2008-092 18981259
5. Antonelli M, Buttarelli FR, Arcella A, Nobusawa S, Donofrio V, Oghaki H, Giangaspero F (2010) Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas. J Neurooncol, Feb 21. (in press)
6. RI Jakacki A Yates SM Blaney T Zhou R Timmerman AM Ingle L Flom MD Prados PC Adamson IF Pollack 2008 A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood Neuro Oncol 10 569 576 10.1215/15228517-2008-019 1:CAS:528:DC%2BD1cXhtVymsrbJ 18497327
7. JL Villano TE Seery LR Bressler 2009 Temozolomide in malignant gliomas: current use and future targets Cancer Chemother Pharmacol 64 647 655 10.1007/s00280-009-1050-5 1:CAS:528:DC%2BD1MXptFCksLw%3D 19543728
8. E Hegi AC Diserens T Gorlia MF Hamou N de Tribolet M Weller JM Kros JA Hainfellner W Mason L Mariani JE Bromberg P Hau RO Mirimanoff JG Cairncross RC Janzer R Stupp 2005 MGMT gene silencing and benefit from temozolomide in glioblastoma N Engl J Med 10 997 1003 10.1056/NEJMoa043331
9. M Esteller SR Hamilton PC Burger SB Baylin JG Herman 1999 Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 59 793 797 1:CAS:528:DyaK1MXht1Sjurk%3D 10029064
10. ME Hegi AC Diserens S Godard PY Dietrich L Regli S Ostermann P Otten G Van Melle N de Tribolet R Stupp 2004 Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide Clin Cancer Res 15 1871 1874 10.1158/1078-0432.CCR-03-0384
11. T Anda HK Shabani K Tsunoda Y Tokunaga M Kaminogo S Shibata T Hayashi M Iseki 2003 Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase pi in glioblastoma and the survival of the patients treated with nimustine hydrochloride: an immunohistochemical analysis Neurol Res 25 241 248 10.1179/016164103101201445 1:CAS:528: DC%2BD3sXjsl2qtbY%3D 12739231
12. M Brell A Tortosa E Verger JM Gil N Viñolas S Villá JJ Acebes L Caral T Pujol I Ferrer T Ribalta F Graus 2005 Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas Clin Cancer Res 11 5167 5174 10.1158/1078-0432.CCR-05-0230 1:CAS:528: DC%2BD2MXmt12qtbg%3D 16033832
13. AM Donson SO Addo-Yobo MH Handler L Gore NK Foreman 2007 MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma Pediatr Blood Cancer 48 403 407 10.1002/pbc.20803 16609952
14. IF Pollack RL Hamilton RW Sobol J Burnham AJ Yates EJ Holmes T Zhou JL Finlay 2006 O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 cohort J Clin Oncol 24 3431 3437 10.1200/JCO.2006.05.7265 1:CAS:528: DC%2BD28Xot1KisLo%3D 16849758
15. M Preusser R Charles Janzer J Felsberg G Reifenberger MF Hamou AC Diserens R Stupp T Gorlia C Marosi H Heinzl JA Hainfellner M Hegi 2008 Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker Brain Pathol 18 520 532 1:CAS:528:DC%2BD1cXht1CjtLvM 18400046