Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho- morpholinylmethyl)]phenyl-1,4-DHP compound: Comparison with other compounds of the same kind and relationship with logP values

European Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2010, Pages 4622-4630

  Abrego, Victor H ^a   Martínez Pérez, Beatriz ^a   Torres, Luis A ^a   Ángeles, Enrique ^a   Martínez, Luisa ^a   Marroquín Pascual, J Lorena ^a   Moya Hernández, Rosario ^a   Amaro Recillas, Héctor Adrián ^a   Rueda Jackson, Juan Carlos ^a   Rodríguez Barrientos, Damaris ^b   Rojas Hernández, Alberto ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Antihypertensives; Bis(morpholinylmethyl)phenols; Cardiovascular effects; DHP; LogP; PKa values

Indexed keywords

4 (4 HYDROXY 3,5 BIS(MORPHOLIN 4 YLMETHYL)PHENYL) 2,6 DIMETHYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID DIETHYL ESTER; ANTIARRHYTHMIC AGENT; ANTIHYPERTENSIVE AGENT; LQM 300; LQM 301; LQM 302; LQM 303; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; COMPARATIVE STUDY; CONTROLLED STUDY; MALE; NONHUMAN; PKA; RAT; STATISTICAL SIGNIFICANCE; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DIHYDROPYRIDINES; HEART RATE; MALE; MORPHOLINES; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 77956183343     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.027     Document Type: Article

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