Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-β1 decrease rabbit intervertebral disc degeneration

Spine Journal

Volumn 10, Issue 9, 2010, Pages 802-810

  Yang, Huilin ^a   Wu, Jian ^a   Liu, Jiayong ^a,b   Ebraheim, Molly ^b   Castillo, Sharmaine ^b   Liu, Xiaochen ^b   Tang, Tiansi ^a   Ebraheim, Nabil A ^b  

^a SOOCHOW UNIVERSITY   (China)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Apoptosis; Disc space height index; Intervertebral disc degeneration; Mesenchymal stem cells; Nucleus pulposus

Indexed keywords

COLLAGEN TYPE 2; GELATIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANNULUS FIBROSUS; APOPTOSIS; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXPERIMENTAL STUDY; HISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; PRIORITY JOURNAL; RABBIT; SPINE;

ANIMALS; APOPTOSIS; COLLAGEN TYPE II; GELATIN; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MAGNETIC RESONANCE IMAGING; MESENCHYMAL STEM CELL TRANSPLANTATION; RABBITS; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956183003     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2010.06.019     Document Type: Article

References (14)

1. S.M. Richardson, R.V. Walker, and S. Parker Intervertebral disc cell-mediated mesenchymal stem cell differentiation Stem Cells 24 2006 707 716
2. S. Sobajima, G. Vadala, and A. Shimer Feasibility of a stem cell therapy for intervertebral disc degeneration Spine J 8 2008 888 896
3. D. Sakai, J. Mochida, and T. Iwashina Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration Spine 30 2005 2379 2387
4. S.M. Richardson, J.M. Curran, and R. Chen The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-l-lactic acid (PLLA) scaffolds Biomaterials 27 2006 4069 4078
5. T. Nomura, J. Mochida, and M. Okuma Nucleus pulposus allograft retards intervertebral disc degeneration Clin Orthop Relat Res 389 2001 94 101
6. H.E. Gruber, T.L. Johnson, and K. Leslie Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat Spine 27 2002 1626 1633
7. M. Bendtsen, X. Zou, H.S. Jørgensen, and C.E. Bünger Autologous stem cell transplantation in IDD halts further progression: a porcine study Trans Orthop Res Soc 33 2008 Paper no. 1390
8. T. Ganey, W. Hutton, and R. Schreiber Adipose-derived regenerative cell transplantation: evaluating intervertebral disc repair in a canine model Trans Orthop Res Soc 33 2008 Paper no. 333
9. D. Sakai, J. Mochida, and Y. Yamamoto Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration Biomaterials 24 2003 3531 3541
10. D. Sakai, J. Mochida, and T. Iwashina Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc Biomaterials 27 2006 335 345
11. R. Tuli, S. Tuli, and S. Nandi Transforming growth factor-β-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk J Biol Chem 278 2003 41227 41236
12. C.J. Siepe, W. Hitzl, and P. Meschede Interdependence between disc space height, range of motion and clinical outcome in total lumbar disc replacement Spine 34 2009 904 916
13. M.H. Kong, D.H. Do, and M. Miyazaki Rabbit model for in vivo study of intervertebral disc degeneration and regeneration J Korean Neurosurg Soc 44 2008 327 333
14. J. Young, C. Kyeong, and H. Sung Subsidence after anterior lumbar interbody fusion using paired stand-alone rectangular cages Eur Spine J 15 2006 16 22