Multifactorial Analysis of Affinity-Mass Spectrometry Data from Serum Protein Samples: A Strategy to Distinguish Patients with Preeclampsia from Matching Control Individuals

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 10, 2010, Pages 1699-1711

  Pecks, Ulrich ^a   Seidenspinner, Franka ^a,b   Röwer, Claudia ^b   Reimer, Toralf ^b   Rath, Werner ^a   Glocker, Michael O ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABUNDANT ION; CONTROL GROUPS; DENSITOMETRIC ANALYSIS; DIFFERENTIAL ANALYSIS; ION SIGNALS; MAGNETIC BEADS; MASS SPECTROMETRY DATA; MATCHING CONTROL; MEAN CONCENTRATIONS; MULTIFACTORIAL ANALYSIS; PREECLAMPSIA; PREGNANT WOMAN; PROTEIN BANDS; PROTEOMES; REVERSED PHASE; SDS-PAGE; SERUM PROTEINS; SERUM SAMPLES; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS; TRANSTHYRETIN;

ELECTROPHORESIS; GELS; IONS; MASS SPECTROMETRY; PROTEINS; SODIUM SULFATE;

BODY FLUIDS;

APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN C3; HUMAN SERUM ALBUMIN; PLASMA PROTEIN; PREALBUMIN; RETINOL BINDING PROTEIN 4;

ACCURACY; ADULT; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DENSITOMETRY; DIAGNOSTIC ACCURACY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HUMAN; MASS SPECTROMETRY; NEPHELOMETRY; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECIPITATION; PREECLAMPSIA; PREGNANCY; PROTEIN ANALYSIS; PROTEOMICS; SENSITIVITY AND SPECIFICITY; SYSTOLIC BLOOD PRESSURE;

ADULT; BIOLOGICAL MARKERS; BLOOD PROTEINS; CASE-CONTROL STUDIES; COMPUTATIONAL BIOLOGY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; MICROSPHERES; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; PEPTIDE MAPPING; PRE-ECLAMPSIA; PREALBUMIN; PREDICTIVE VALUE OF TESTS; PREGNANCY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STATISTICS, NONPARAMETRIC;

EID: 77956182056     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.12.013     Document Type: Article

References (60)

1. Roberts J., Cooper D. Pathogenesis and Genetics of Preeclampsia. Lancet 2001, 357:53-56.
2. Lyall F., Greer I. The Vascular Endothelium in Normal Pregnancy and Preeclampsia. Rev. Reprod 1996, 1:107-116.
3. Heitner J.C., Koy C., Reimer T., Kreutzer M., Gerber B., Glocker M.O. Differentiation of HELLP Patients from Healthy Pregnant Women by Proteome Analysis. J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci 2006, 840:10-19.
4. Kadyrov M., Kingdom J.C.P., Huppertz B. Divergent Trophoblast Invasion and Apoptosis in Placental Bed Spiral Arteries from Pregnancies Complicated by Maternal Anemia and Early-Onset Preeclampsia/Intrauterine Growth Restriction. Am. J. Obstet. Gynecol 2006, 194:557-563.
5. Reister F., Frank H.G., Kingdom J.C.P., Heyl W., Kaufmann P., Rath W., Huppertz B. Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women. Lab. Invest 2001, 81:1143-1152.
6. Holzgreve W., Ghezzi F., Di Naro E., Gänshirt D., Maymon E., Hahn S. Disturbed Feto-Maternal Cell Traffic in Preeclampsia. Obstet. Gynaecol 1998, 91:669-672.
7. Lo D.Y.M., Leung T.N., Tein M.S.C., Sargent I.L., Zhang J., Lau T.K., Haines C.J., Redman C.W.G. Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia. Clin. Chem 1999, 45:184-188.
8. Levine R.J., Lam C., Qian C., Yu K.F., Maynard S.E., Sachs B.P., Sibai B.M., Epstein F.H., Romero R., Thadhani R., Karumanchi S.A. Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia. N. Engl. J. Med 2006, 355:992-1005.
9. Levine R.J., Maynard S.E., Qian C., Lim K.H., England L.J., Yu K.F., Schistermann E.F., Thadhani R., Sachs B.P., Epstein F.H., Sibai B.M., Sukhatme V.P., Karumanchi S.A. Circulating Angiogenic Factors and the Risk of Preeclampsia. N. Engl. J. Med 2004, 350:672-683.
10. Aquilina J., Barnet A., Thompson O., Harrington K. Second-Trimester Maternal Serum Inhibin A Concentration as an Early Marker for Preeclampsia. Am. J. Obstet. Gynecol 1999, 181:131-136.
11. Bersinger N.A., Smárason A.K., Muttukrishna S., Groome N.P. Women with Preeclampsia Have Increased Serum Levels of Pregnancy-Associated Plasma Protein A (PAPP-A), Inhibin A, Activin A, and Soluble E-Selectin. Hypertens. Pregnancy 2003, 22:45-55.
12. Cetin I., Cozzi V., Pasqualini F., Nebuloni M., Garlanda C., Vago L., Pardi G., Mantovani A. Elevated Maternal Levels of the Long Pentraxin 3 (PTX3) in Preeclampsia and Intrauterine Growth Restriction. Am. J. Obstet. Gynecol 2006, 194:1347-1353.
13. Huppertz B., Sammar M., Chefetz I., Neumaier-Wagner P., Bartz C., Meiri H. Longitudinal Determination of Serum Placental Protein 13 During Development of Preeclampsia. Fetal Diagn. Ther 2008, 24:230-236.
14. Muttukrishna S., Knight P.G., Groome N.P., Redman C.W.G., Ledger W.L. Activin A and Inhibin A as Possible Endocrine Markers for Preeclampsia. Lancet 1997, 349:1285-1288.
15. Nicolaides K.H., Bindra R., Turan O.M., Chefetz I., Sammar M., Meiri H., Tal J., Cuckle H.S. A Novel Approach to First-Trimester Screening for Early Preeclampsia Combining Serum PP-13 and Doppler Ultrasound. Ultrasound Obstet. Gynecol 2006, 27:13-17.
16. Conde-Agudelo A., Villar J., Lindheimer M. World Health Organization Systematic Review of Screening Tests for Preeclampsia. Obstet. Gynaecol 2004, 104:1367-1391.
17. Koy C., Heitner J.C., Woisch R., Kreutzer M., Serrano-Fernandez P., Gohlke R., Reimer T., Glocker M.O. Cryodetector Mass Spectrometry Profiling of Plasma Samples for HELLP Diagnosis: An Exploratory Study. Proteomics 2005, 5:3079-3087.
18. Palmblad M., Tiss A., Cramer R. Mass Spectrometry in Clinical Proteomics-from the Present to the Future. Proteomics Clin. Appl 2009, 3:6-17.
19. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am. J. Obstet. Gynecol 2000, 183:S1-S22.
20. Brown M.A., Lindheimer M.D., de Swiet M., Van Assche A., Moutquin J.M. The Classification and Diagnosis of the Hypertensive Disorders of Pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens. Pregnancy 2001, 20:9-14.
21. Villar J., Carroli G., Wojdyla D., Abalos E., Giordano D., Ba'aqeel H., Farnot U., Bergsjo P., Bakketeig L., Lumbiganon P., Campodónico L., Al-Mazrou Y., Lindheimer M., Kramer M. Preeclampsia, Gestational Hypertension and Intrauterine Growth Restriction, Related or Independent Conditions?. Am. J. Obstet. Gynecol 2006, 194:921-931.
22. von Dadelszen P., Magee L.A., Roberts J.M. Subclassification of Preeclampsia. Hypertens. Pregnancy 2003, 22:143-148.
23. Voigt M., Schneider K.T., Jährig K. Analysis of a 1992 Birth Sample in Germany. 1: New Percentile Values of the Body Weight of Newborn Infants. Geburtshilfe Frauenheilkd 1996, 56:550-558.
24. Cohn E.J., Oncley J.L., Strong L.E., Hughes J., Walter L., Armstrong J. S. Howard Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. I. The Characterization of the Protein Fractionations of Human Plasma. J. Clin. Invest 1944, 23:417-432.
25. Mikkat S., Koy C., Ulbrich M., Ringel B., Glocker M.O. Mass Spectrometric Protein Structure Characterization Reveals Cause of Migration Differences of Haptoglobin α Chains in Two-Dimensional Gel Electrophoresis. Proteomics 2004, 4:3921-3932.
26. Wilcoxon F. Individual Comparisons by Ranking Methods. Biometrics 1945, 1:80-83.
27. Kruskal W.H., Wallis A.W. Use of Ranks in One-Criterion Variance Analysis. J. Am. Stat. Assoc 1952, 47:583-621.
28. Chambers J.M., Freeny A.E., Heiberger R.M. Analysis of Variance; Designed Experiments. In Statistical Models in S 1992, 145. Wadsworth and Brooks/Cole, Pacific Grove, CA. J.M. Chambers, T.J. Hastie (Eds.).
29. Walpole R.E., Myers R. Probability and Statistics for Engineers and Scientists 1993, Macmillan, New York. 5th ed.
30. Stephens M.A. EDF Statistics for Goodness of Fit and Some Comparisons. J. Am. Stat. Assoc 1974, 69:730-737.
31. Tukey J.W. Exploratory Data Analysis 1977, Addison Wesley, Munich. 1st ed.
32. Kienbaum M., Koy C., Montgomery H.V., Drynda S., Lorenz P., Illges H., Tanaka K., Kekow J., Guthke R., Thiesen H.J., Glocker M.O. Mass Spectrometric Characterization of Apheresis Samples from Rheumatoid Arthritis Patients for the Improvement of Immunoadsorption Therapy-A Pilot Study. Proteom. Clin. Appl 2009, 3:797-809.
33. Laemmli U.K. Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4. Nature 1970, 227:680-685.
34. Bantscheff M., Ringel B., Madi A., Schnabel R., Glocker M.O., Thiesen H.J. Differential Proteome Analysis and Mass Spectrometric Characterization of Germ Line Development-Related Proteins of Caenorhabditis elegans. Proteomics 2004, 4:2283-2295.
35. Candiano G., Bruschi M., Musante L., Santucci L., Ghiggeri G.M., Carnemolla B., Orecchia P., Zardi L., Righetti P.G. Blue Silver: A Very Sensitive Colloidal Coomassie G-250 Staining for Proteome Analysis. Electrophoresis 2004, 25:1327-1333.
36. Koy C., Mikkat S., Raptakis E., Sutton C., Resch M., Tanaka K., Glocker M.O. Matrix-Assisted Laser Desorption/Ionization-Quadrupole Ion Trap-Time of Flight Mass Spectrometry Sequencing Resolves Structures of Unidentified Peptides Obtained by In-Gel Tryptic Digestion of Haptoglobin Derivatives from Human Plasma Proteomes. Proteomics 2003, 3:851-858.
37. n sequencing. Eur. J. Mass Spectrom 2004, 10:393-399.
38. Schoonjans F., Zalata A., Depuydt C.E., Comhaire F.H. MedCalc: A New Computer Program for Medical Statistics. Comput. Methods Programs Biomed 1995, 48:257-262.
39. Obuchowski N.A., Zhou X.-H. Prospective Studies of Diagnostic Test Accuracy When Disease Prevalence is Low. Biostatistics 2002, 3:477-492.
40. Oettle C., Hall D., Roux A., Grové D. Early Onset Severe Preeclampsia: Expectant Management at a Secondary Hospital in Close Association with a Tertiary Institution. BJOG 2005, 112:84-88.
41. Rath W., Faridi A., Dudenhausen J.W. HELLP Syndrome. J. Perinat. Med 2000, 28:249-260.
42. Bellamy L., Casas J.P., Hingorani A.D., Williams D.J. Preeclampsia and Risk of Cardiovascular Disease and Cancer in Later Life: Systematic Review and Meta-Analysis. Br. Med. J 2007, 335:974-985.
43. Coomarasamy A., Honest H., Papaioannou S., Gee H., Khan K.S. Aspirin for Prevention of Preeclampsia in Women With Historical Risk Factors: A Systematic Review. Obstet. Gynaecol 2003, 101:1319-1332.
44. Watanabe H., Hamada H., Yamada N., Sohda S., Yamakawa-Kobayashi K., Yoshikawa H., Arinami T. Proteome Analysis Reveals Elevated Serum Levels of Clusterin in Patients with Preeclampsia. Proteomics 2004, 4:537-543.
45. de Silva H.V., Stuart W.D., Park Y.B., Mao S.J., Gil C.M., Wetterau J.R., Busch S.J., Harmony J.A. Purification and Characterization of Apolipoprotein. J. Biol. Chem 1990, 265:14292-14297.
46. Murphy B.F., Kirszbaum L., Walker I.D., d'Apice A.J. SP-40,40, a Newly Identified Normal Human Serum Protein Found in the SC5b-9 Complex of Complement and in the Immune Deposits in Glomerulonephritis. J. Clin. Invest 1988, 81:1858-1864.
47. Blumenstein M., McMaster M.T., Black M.A., Wu S., Prakash R., Cooney J., McCowan L.M., Cooper G.J., North R.A. A Proteomic Approach Identifies Early Pregnancy Biomarkers for Preeclampsia: Novel Linkages Between a Predisposition to Preeclampsia and Cardiovascular Disease. Proteomics 2009, 9:2929-2945.
48. Vaisar T., Pennathur S., Green P.S., Gharib S.A., Hoofnagle A.N., Cheung M.C., Byun J., Vuletic S., Kassim S., Singh P., Chea H., Knopp R., Brunzell J., Geary R., Chait A., Zhao X.Q., Elkon K., Marcovina S., Ridker P., Oram J., Heinecke J.W. Shotgun Proteomics Implicates Protease Inhibition and Complement Activation in the Anti-Inflammatory Properties of HDL. J. Clin. Invest 2007, 117:746-756.
49. Atkinson K.R., Blumenstein M., Black M.A., Wu S.H., Kasabov N., Taylor R.S., Cooper G.J., North R.A. SCOPE Consortium. An Altered Pattern of Circulating Apolipoprotein E3 Isoforms is Implicated in Preeclampsia. J. Lipid Res 2009, 50:71-80.
50. Sapin V., Alexandre M.C., Chaib S., Bournazeau J.A., Sauvant P., Borel P., Jacquetin B., Grolier P., Lémery D., Dastugue B., Azais-Braesco V. Effect of Vitamin A Status at the End of Term Pregnancy on the Saturation of Retinol Binding Protein with Retinol. Am. J. Clin. Nutr 2000, 71:537-543.
51. Dickson P.W., Howlett G.J., Schreiber G. Metabolism of Prealbumin in Rats and Changes Induced by Acute Inflammation. Eur. J. Biochem 1982, 129:289-293.
52. Raz A., Goodman D.S. The Interaction of Thyroxine with Human Plasma Prealbumin and with the Prealbumin-Retinol-Binding Protein Complex. J. Biol. Chem 1969, 244:3230-3237.
53. Landers K.A., McKinnon B.D., Li H., Subramaniam V.N., Mortimer R.H., Richard K. Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin. J. Clin. Endocrinol. Metab 2009, 94:2610-2616.
54. Alldridge L., Metodieva G., Greenwood C., Al-Janabi K., Thwaites L., Sauven P., Metodiev M. Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry. J. Proteome Res 2008, 7:1458-1469.
55. Röwer C., Vissers J.P.C., Koy C., Kipping M., Hecker M., Reimer T., Gerber B., Thiesen H.J., Glocker M.O. A Proteome Signature for Breast Carcinoma Derived from Label-Free Nanoscale LC-MS Protein Expression Profiling of Tumor and Glandular Tissue-A Methodology Study. Anal. Bioanal. Chem 2009, in press.
56. Seike M., Kondo T., Fujii K., Yamada T., Gemma A., Kudoh S., Hirohashi S. Proteomic Signature of Human Cancer Cells. Proteomics 2004, 4:2776-2788.
57. Wang M., You J., Bemis K.G., Tegeler T.J., Brown D.P.G. Label-Free Mass Spectrometry-Based Protein Quantification Technologies in Proteomic Analysis. Brief Funct. Genom. Proteom 2008, 7:329-339.
58. Yamada M., Fujii K., Koyama K., Hirohashi S., Kondo T. The Proteomic Profile of Pancreatic Cancer Cell Lines Corresponding to Carcinogenesis and Metastasis. J. Proteome Bioinform 2009, 2:1-18.
59. Shimizu A., Nakanishi T., Miyazaki A. Detection and Characterization of Variant and Modified Structures of Proteins in Blood and Tissues by Mass Spectrometry. Mass Spectrom. Rev 2006, 25:686-712.
60. Huppertz B. Placental Origins of Preeclampsia: Challenging the Current Hypothesis. Hypertension 2008, 51:970-975.