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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5548-5551

Discovery of biphenylketones as dual modulators of inflammation and bone loss

(4) Greig, Iain R a Coste, Emmanuel b Ralston, Stuart H b Van'T Hof, Rob J b

a UNIVERSITY OF ABERDEEN (United Kingdom)

b UNIVERSITY OF EDINBURGH (United Kingdom)

Author keywords

Bone loss; Inflammation; NF B; RANKL; Rheumatoid arthritis; TNF

Indexed keywords

ABD 328; ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; BENZOPHENONE; I KAPPA B; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; FEMALE; IC 50; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS; BENZENE DERIVATIVES; CELL LINE; CELL SURVIVAL; FEMALE; INFLAMMATION; KETONES; MACROPHAGES; MICE; NF-KAPPA B; OSTEOCLASTS; OSTEOPOROSIS; POLYCYCLIC HYDROCARBONS, AROMATIC; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956175125 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.07.055 Document Type: Article

Times cited : (3)

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- note
- 2): C, H; MS, m/z: calcd, 337.24; found, 337.28, 339.30 (M, M+2).

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