Influence of recipient race on the outcome of simultaneous pancreas and kidney transplantation

American Journal of Transplantation

Volumn 10, Issue 9, 2010, Pages 2074-2081

  Luan, F L ^a   Kommareddi, M ^a   Cibrik, D M ^a   Samaniego, M ^a   Ojo, A O ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Outcomes; racial disparity; simultaneous pancreas kidney transplantation

Indexed keywords

ALEMTUZUMAB; INTERLEUKIN 2 RECEPTOR ANTIBODY; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS;

ADULT; ARTICLE; DEMOGRAPHY; FEMALE; FOLLOW UP; GRAFT FAILURE; GRAFT REJECTION; GRAFT SURVIVAL; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; RACE DIFFERENCE; RISK FACTOR;

ADULT; AFRICAN AMERICANS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KAPLAN-MEIERS ESTIMATE; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PANCREAS TRANSPLANTATION; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 77956167060     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2010.03211.x     Document Type: Article

References (43)

1. Smets YF, Westendorp RG, van der Pijl JW et al. Effect of simultaneous pancreas-kidney transplantation on mortality of patients with type-1 diabetes mellitus and end-stage renal failure. Lancet 1999 353 : 1915 1919.
2. Ojo AO, Meier-Kriesche HU, Hanson JA et al. The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation 2001 71 : 82 90.
3. Reddy KS, Stablein D, Taranto S et al. Long-term survival following simultaneous kidney-pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure. Am J Kidney Dis 2003 41 : 464 470.
4. Luan FL, Miles CD, Cibrik DM, Ojo AO. Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus. Transplantation 2007 84 : 541 544.
5. Coppelli A, Giannarelli R, Mariotti R et al. Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients. Transplantation 2003 76 : 974 976.
6. Jukema JW, Smets YF, van der Pijl JW et al. Impact of simultaneous pancreas and kidney transplantation on progression of coronary atherosclerosis in patients with end-stage renal failure due to type 1 diabetes. Diabetes Care 2002 25 : 906 911.
7. Larsen JL, Colling CW, Ratanasuwan T et al. Pancreas transplantation improves vascular disease in patients with type 1 diabetes. Diabetes Care 2004 27 : 1706 1711.
8. Biesenbach G, Konigsrainer A, Gross C, Margreiter R. Progression of macrovascular diseases is reduced in type 1 diabetic patients after more than 5 years successful combined pancreas-kidney transplantation in comparison to kidney transplantation alone. Transpl Int 2005 18 : 1054 1060.
9. Salvalaggio PR, Dzebisashvili N, Pinsky B et al. Incremental value of the pancreas allograft to the survival of simultaneous pancreas-kidney transplant recipients. Diabetes Care 2009 32 : 600 602.
10. Morath C, Zeier M, Dohler B, Schmidt J, Nawroth PP, Opelz G. Metabolic control improves long-term renal allograft and patient survival in type 1 diabetes. J Am Soc Nephrol 2008 19 : 1557 1563.
11. Andreoni KA, Brayman KL, Guidinger MK, Sommers CM, Sung RS. Kidney and pancreas transplantation in the United States, 1996-2005. Am J Transplant 2007 7 (5 Pt 2 1359 1375.
12. Gruessner AC, Sutherland DE. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). Cecka JM, Terasaki P, eds. Clinical transplants. Los Angeles: Terasaki Foundation Laboratory, 2008 : 45 56.
13. Mayer-Davis EJ, Beyer J, Bell RA et al. Diabetes in African American youth: Prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009 32 (Suppl 2 S112 S122.
14. Bell RA, Mayer-Davis EJ, Beyer JW et al. Diabetes in non-Hispanic white youth: Prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009 32 (Suppl 2 S102 S111.
15. Xue JL, Eggers PW, Agodoa LY, Foley RN, Collins AJ. Longitudinal study of racial and ethnic differences in developing end-stage renal disease among aged medicare beneficiaries. J Am Soc Nephrol 2007 18 : 1299 1306.
16. Crook ED, Patel SR. Diabetic nephropathy in African-American patients. Curr Diab Rep 2004 4 : 455 461.
17. National Institute of Health (NIH), (NIDDK) NIoDaDaKD. 2009 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. 2009.
18. Kirk JK, D'Agostino RB, Jr., Bell RA et al. Disparities in HbA1c levels between African-American and non-Hispanic white adults with diabetes: A meta-analysis. Diabetes Care 2006 29 : 2130 2136.
19. Isaacs RB, Lobo PI, Nock SL, Hanson JA, Ojo AO, Pruett TL. Racial disparities in access to simultaneous pancreas-kidney transplantation in the United States. Am J Kidney Dis 2000 36 : 526 533.
20. Melancon JK, Kucirka LM, Boulware LE et al. Impact of medicare coverage on disparities in access to simultaneous pancreas and kidney transplantation. Am J Transplant 2009 9 : 2785 2791.
21. Weiss AS, Smits G, Wiseman AC. Simultaneous pancreas-kidney versus deceased donor kidney transplant: Can a fair comparison be made Transplantation 2009 87 : 1402 1410.
22. Young CJ, Gaston RS. Renal transplantation in black Americans. N Engl J Med 2000 343 : 1545 1552.
23. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, Kahan BD. Possible contribution of pretransplant immune responder status to renal allograft survival differences of black versus white recipients. Transplantation 1991 51 : 338 342.
24. Schweitzer EJ, Yoon S, Fink J et al. Mycophenolate mofetil reduces the risk of acute rejection less in African-American than in Caucasian kidney recipients. Transplantation 1998 65 : 242 248.
25. Neylan JF. Immunosuppressive therapy in high-risk transplant patients: Dose-dependent efficacy of mycophenolate mofetil in African-American renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group. Transplantation 1997 64 : 1277 1282.
26. Rogers J, Baliga PK, Chavin KD et al. Effect of ethnicity on outcome of simultaneous pancreas and kidney transplantation. Am J Transplant 2003 3 : 1278 1288.
27. Zhang R, Florman S, Devidoss S et al. A comparison of long-term survivals of simultaneous pancreas-kidney transplant between African American and Caucasian recipients with basiliximab induction therapy. Am J Transplant 2007 7 : 1815 1821.
28. Rogers J, Stratta RJ, Lo A, Alloway RR. Inferior late functional and metabolic outcomes in African American simultaneous kidney-pancreas recipients. Transplant Proc 2005 37 : 3552 3554.
29. Dickinson DM, Ellison MD, Webb RL. Data sources and structure. Am J Transplant 2003 3 (Suppl 4 13 28.
30. Hill M, Garcia R, Dunn T, Kandaswamy R, Sutherland DE, Humar A. What happens to the kidney in an SPK transplant when the pancreas fails due to a technical complication Clin Transplant 2008 22 : 456 461.
31. Humar A, Ramcharan T, Kandaswamy R, Gruessner RW, Gruessner AC, Sutherland DE. Technical failures after pancreas transplants: Why grafts fail and the risk factors-A multivariate analysis. Transplantation 2004 78 : 1188 1192.
32. Sansalone CV, Maione G, Aseni P et al. Surgical complications are the main cause of pancreatic allograft loss in pancreas-kidney transplant recipients. Transplant Proc 2005 37 : 2651 2653.
33. Young CJ, Kew C. Health disparities in transplantation: Focus on the complexity and challenge of renal transplantation in African Americans. Med Clin North Am 2005 89 : 1003 1031, ix.
34. Feyssa E, Jones-Burton C, Ellison G, Philosophe B, Howell C. Racial/ethnic disparity in kidney transplantation outcomes: Influence of donor and recipient characteristics. J Natl Med Assoc 2009 101 : 111 115.
35. Organ Procurement and Transplantation Network/Human Resources and Service Administration. 2009. Available at : http://optn.transplant.hrsa.gov/ latestData. Accessed April 1, 2010.
36. Gaston RS, Hudson SL, Deierhoi MH et al. Improved survival of primary cadaveric renal allografts in blacks with quadruple immunosuppression. Transplantation 1992 53 : 103 109.
37. Meier-Kriesche HU, Ojo AO, Leichtman AB et al. Effect of mycophenolate mofetil on long-term outcomes in African American renal transplant recipients. J Am Soc Nephrol 2000 11 : 2366 2370.
38. Rogers J, Stratta RJ, Alloway RR, Lo A, Hodge EE. African-American ethnicity is no longer a risk factor for early adverse outcomes in simultaneous kidney-pancreas transplantation with contemporary immunosuppression. Transplant Proc 2004 36 : 1055 1057.
39. Israni AK, Feldman HI, Propert KJ, Leonard M, Mange KC. Impact of simultaneous kidney-pancreas transplant and timing of transplant on kidney allograft survival. Am J Transplant 2005 5 : 374 382.
40. Burke GW, 3rd., Kaufman DB, Millis JM et al. Prospective, randomized trial of the effect of antibody induction in simultaneous pancreas and kidney transplantation: Three-year results. Transplantation 2004 77 : 1269 1275.
41. Swanson SJ, Hypolite IO, Agodoa LY et al. Effect of donor factors on early graft survival in adult cadaveric renal transplantation. Am J Transplant 2002 2 : 68 75.
42. Bunnapradist S, Cho YW, Cecka JM, Wilkinson A, Danovitch GM. Kidney allograft and patient survival in type I diabetic recipients of cadaveric kidney alone versus simultaneous pancreas kidney transplants: A multivariate analysis of the UNOS database. J Am Soc Nephrol 2003 14 : 208 213.
43. Sollinger HW, Odorico JS, Becker YT, D'Alessandro AM, Pirsch JD. One thousand simultaneous pancreas-kidney transplants at a single center with 22-year follow-up. Ann Surg 2009 Epub ahead of print.