Progress Toward Improved Understanding of Infection-Related Preterm Birth

Clinics in Perinatology

Volumn 37, Issue 3, 2010, Pages 677-688

  Randis, Tara M ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Bacterial vaginosis; Chorioamnionitis; Fetal inflammatory response; Preterm birth

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8;

BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM CULTURE; CAUSAL ATTRIBUTION; CHORIOAMNIONITIS; CLINICAL TRIAL; FETUS OUTCOME; GARDNERELLA INFECTION; HUMAN; IMMUNE RESPONSE; INFANT; INFECTION COMPLICATION; INTRAUTERINE INFECTION; MATERNAL DISEASE; NEWBORN INFECTION; POLYMERASE CHAIN REACTION; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; PROTEOMICS; REVIEW; VAGINITIS;

FEMALE; GENITAL DISEASES, FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; MORBIDITY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREMATURE BIRTH; RISK FACTORS;

EID: 77956139245     PISSN: 00955108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clp.2010.06.001     Document Type: Review

References (88)

1. Knox I.C., Hoerner J.K. The role of infection in premature rupture of the membranes. Am J Obstet Gynecol 1950, 59:190-194.
2. Bobitt J.R., Ledger W.J. Unrecognized amnionitis and prematurity: a preliminary report. J Reprod Med 1977, 19:8-12.
3. Klebanoff M.A., Regan J.A., Rao A.V., et al. Outcome of the Vaginal Infections and Pre-maturity Study: results of a clinical trial of erythromycin among pregnant women colonized with group B streptococci. Am J Obstet Gynecol 1995, 172:1540-1545.
4. Kenyon S., Pike K., Jones D.R., et al. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous pre-term labour: 7-year follow-up of the ORACLE II trial. Lancet 2008, 372:1319-1327.
5. Kenyon S., Pike K., Jones D.R., et al. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Lancet 2008, 372:1310-1318.
6. Thorp J.M., Hartmann K.E., Berkman N.D., et al. Antibiotic therapy for the treatment of preterm labor: a review of the evidence. Am J Obstet Gynecol 2002, 186:587-592.
7. Goldenberg R.L., Mwatha A., Read J.S., et al. The HPTN 024 Study: the efficacy of antibiotics to prevent chorioamnionitis and preterm birth. Am J Obstet Gynecol 2006, 194:650-661.
8. Ugwumadu A., Reid F., Hay P., et al. Oral clindamycin and histologic chorioamnionitis in women with abnormal vaginal flora. Obstet Gynecol 2006, 107:863-868.
9. Gotsch F., Romero R., Erez O., et al. The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth. J Matern Fetal Neonatal Med 2009, 22(Suppl 2):5-23.
10. Kim M.J., Romero R., Gervasi M.T., et al. Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection. Lab Invest 2009, 89:924-936.
11. Andrews W.W., Goldenberg R.L., Hauth J.C. Preterm labor: emerging role of genital tract infections. Infect Agents Dis 1995, 4:196-211.
12. Gibbs R.S., Romero R., Hillier S.L., et al. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992, 166:1515-1528.
13. Romero R., Sirtori M., Oyarzun E., et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intra-amniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989, 161:817-824.
14. Iams J.D., Romero R., Culhane J.F., et al. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of pre-term birth. Lancet 2008, 371:164-175.
15. Koumans E.H., Kendrick J.S. Preventing adverse sequelae of bacterial vaginosis: a public health program and research agenda. Sex Transm Dis 2001, 28:292-297.
16. Koumans E.H., Sternberg M., Bruce C., et al. The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis 2007, 34:864-869.
17. Hillier S.L., Nugent R.P., Eschenbach D.A., et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995, 333:1737-1742.
18. Klein L.L., Gibbs R.S. Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Am J Obstet Gynecol 2004, 190:1493-1502.
19. McDonald H.M., Brocklehurst P., Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2007, 1. CD000262.
20. Goldenberg R.L., Culhane J.F., Iams J.D., et al. Epidemiology and causes of preterm birth. Lancet 2008, 371:75-84.
21. Martius J., Eschenbach D.A. The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity-a review. Arch Gynecol Obstet 1990, 247:1-13.
22. Hillier S.L., Krohn M.A., Cassen E., et al. The role of bacterial vaginosis and vaginal bacteria in amniotic fluid infection in women in preterm labor with intact fetal membranes. Clin Infect Dis 1995, 20(Suppl 2):S276-S278.
23. Andrews W.W. Cervicovaginal cytokines, vaginal infection, and preterm birth. Am J Obstet Gynecol 2004, 190:1179.
24. Cauci S., Culhane J.F. Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast. Am J Obstet Gynecol 2007, 196(133):e1-e7.
25. Hedges S.R., Barrientes F., Desmond R.A., et al. Local and systemic cytokine levels in relation to changes in vaginal flora. J Infect Dis 2006, 193:556-562.
26. Stencel-Gabriel K., Gabriel I., Wiczkowski A., et al. Prenatal priming of cord blood T lymphocytes by microbiota in the maternal vagina. Am J Reprod Immunol 2009, 61:246-252.
27. Schwebke J.R., Rivers C., Lee J. Prevalence of gardnerella vaginalis in male sexual partners of women with and without bacterial vaginosis. Sex Transm Dis 2008, 35:78-83.
28. Josey W.E., Schwebke J.R. The polymicrobial hypothesis of bacterial vaginosis causation: a reassessment. Int J STD AIDS 2008, 19:152-154.
29. Gardner H.L., Dukes C.D. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol 1955, 69:962-976.
30. Gelber S.E., Aguilar J.L., Lewis K.L., et al. Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis. J Bacteriol 2008, 190:3896-3903.
31. Holzman C., Leventhal J.M., Qiu H., et al. Factors linked to bacterial vaginosis in nonpregnant women. Am J Public Health 2001, 91:1664-1670.
32. Uscher-Pines L., Hanlon A.L., Nelson D.B. Racial differences in bacterial vaginosis among pregnant women: the relationship between demographic and behavioral predictors and individual BV-related microorganism levels. Matern Child Health J 2009, 13:512-519.
33. Simhan H.N., Bodnar L.M., Krohn M.A. Paternal race and bacterial vaginosis during the first trimester of pregnancy. Am J Obstet Gynecol 2008, 198:196. e1-4.
34. Trabert B., Misra D.P. Risk factors for bacterial vaginosis during pregnancy among African American women. Am J Obstet Gynecol 2007, 197:477. e1-8.
35. Bodnar L.M., Krohn M.A., Simhan H.N. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr 2009, 139:1157-1161.
36. Roth D.E., Jones A.B., Prosser C., et al. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis 2008, 197:676-680.
37. Janssen R., Bont L., Siezen C.L., et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 2007, 196:826-834.
38. White J.H. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun 2008, 76:3837-3843.
39. Wang T.T., Nestel F.P., Bourdeau V., et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004, 173:2909-2912.
40. Hansdottir S., Monick M.M., Hinde S.L., et al. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol 2008, 181:7090-7099.
41. Ginde A.A., Liu M.C., Camargo C.A. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009, 169:626-632.
42. Goldenberg R.L., Hauth J.C., Andrews W.W. Intrauterine infection and preterm delivery. N Engl J Med 2000, 342:1500-1507.
43. Kirschner P., Springer B., Vogel U., et al. Genotypic identification of mycobacteria by nucleic acid sequence determination: report of a 2-year experience in a clinical laboratory. J Clin Microbiol 1993, 31:2882-2889.
44. Lane D.J., Pace B., Olsen G.J., et al. Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses. Proc Natl Acad Sci U S A 1985, 82:6955-6959.
45. DiGiulio D.B., Romero R., Amogan H.P., et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One 2008, 3:e3056.
46. Jalava J., Mantymaa M.L., Ekblad U., et al. Bacterial 16S rDNA polymerase chain reaction in the detection of intra-amniotic infection. Br J Obstet Gynaecol 1996, 103:664-669.
47. Hitti J., Riley D.E., Krohn M.A., et al. Broad-spectrum bacterial rDNA polymerase chain reaction assay for detecting amniotic fluid infection among women in premature labor. Clin Infect Dis 1997, 24:1228-1232.
48. Han Y.W., Shen T., Chung P., et al. Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J Clin Microbiol 2009, 47:38-47.
49. Bracci R., Buonocore G. Chorioamnionitis: a risk factor for fetal and neonatal morbidity. Biol Neonate 2003, 83:85-96.
50. Yoon B.H., Romero R., Park J.S., et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000, 182:675-681.
51. Buhimschi I.A., Christner R., Buhimschi C.S. Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation. BJOG 2005, 112:173-181.
52. Dudley D.J. Pre-term labor: an intra-uterine inflammatory response syndrome?. J Reprod Immunol 1997, 36:93-109.
53. Buhimschi C.S., Weiner C.P., Buhimschi I.A. Proteomics, part II: the emerging role of proteomics over genomics in spontaneous preterm labor/birth. Obstet Gynecol Surv 2006, 61:543-553.
54. Weinberger S.R., Morris T.S., Pawlak M. Recent trends in protein biochip technology. Pharmacogenomics 2000, 1:395-416.
55. Buhimschi C.S., Buhimschi I.A., Abdel-Razeq S., et al. Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res 2007, 61:318-324.
56. Buhimschi C.S., Bhandari V., Hamar B.D., et al. Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Med 2007, 4:e18.
57. Gravett M.G., Novy M.J., Rosenfeld R.G., et al. Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA 2004, 292:462-469.
58. Buhimschi C.S., Rosenberg V.A., Dulay A.T., et al. Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth. Am J Perinatol 2008, 25:175-187.
59. Di Quinzio M.K., Oliva K., Holdsworth S.J., et al. Proteomic analysis and characterisation of human cervico-vaginal fluid proteins. Aust N Z J Obstet Gynaecol 2007, 47:9-15.
60. Pereira L., Reddy A.P., Jacob T., et al. Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid. J Proteome Res 2007, 6:1269-1276.
61. Thompson P.J., Greenough A., Davies E., et al. Fetal C-reactive protein. Early Hum Dev 1993, 32:81-85.
62. Matsuoka T., Matsubara T., Katayama K., et al. Increase of cord blood cytokine-producing T cells in intrauterine infection. Pediatr Int 2001, 43:453-457.
63. Gotsch F., Romero R., Kusanovic J.P., et al. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007, 50:652-683.
64. Gomez R., Romero R., Ghezzi F., et al. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998, 179:194-202.
65. Pacora P., Chaiworapongsa T., Maymon E., et al. Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2002, 11:18-25.
66. Redline R.W. Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonatal Med 2006, 11:296-301.
67. Madsen-Bouterse S.A., Romero R., Tarca A.L., et al. The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol 2010, 63:73-92.
68. Mestan K., Yu Y., Thorsen P., et al. Cord blood biomarkers of the fetal inflammatory response. J Matern Fetal Neonatal Med 2009, 22:379-387.
69. Yoon B.H., Romero R., Shim J.Y., et al. C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. J Matern Fetal Neonatal Med 2003, 14:85-90.
70. Nishimaki S., Sato M., An H., et al. Comparison of markers for fetal inflammatory response syndrome: fetal blood interleukin-6 and neonatal urinary beta(2)-microglobulin. J Obstet Gynaecol Res 2009, 35:472-476.
71. Gupta M., Mestan K.K., Martin C.R., et al. Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births. J Matern Fetal Neonatal Med 2007, 20:39-46.
72. Mohan A.R., Loudon J.A., Bennett P.R. Molecular and biochemical mechanisms of preterm labour. Semin Fetal Neonatal Med 2004, 9:437-444.
73. Romero R., Gomez R., Ghezzi F., et al. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998, 179:186-193.
74. Janeway C. Immunobiology: the immune system in health and disease 2005, Garland Science, New York. 6th edition.
75. Nelson K.B. The epidemiology of cerebral palsy in term infants. Ment Retard Dev Disabil Res Rev 2002, 8:146-150.
76. Wu Y.W., Colford J.M. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA 2000, 284:1417-1424.
77. Malaeb S., Dammann O. Fetal inflammatory response and brain injury in the preterm newborn. J Child Neurol 2009, 24:1119-1126.
78. Mittendorf R., Covert R., Montag A.G., et al. Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates. J Perinat Med 2005, 33:428-434.
79. Yoon B.H., Romero R., Kim K.S., et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999, 181:773-779.
80. Yanowitz T.D., Jordan J.A., Gilmour C.H., et al. Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations. Pediatr Res 2002, 51:310-316.
81. Romero R., Espinoza J., Goncalves L.F., et al. Fetal cardiac dysfunction in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2004, 16:146-157.
82. Yoon B.H., Kim Y.A., Romero R., et al. Association of oligohydramnios in women with pre-term premature rupture of membranes with an inflammatory response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1999, 181:784-788.
83. Yoon B.H., Romero R., Jun J.K., et al. An increase in fetal plasma cortisol but not dehydroepiandrosterone sulfate is followed by the onset of preterm labor in patients with pre-term premature rupture of the membranes. Am J Obstet Gynecol 1998, 179:1107-1114.
84. Kim Y.M., Romero R., Chaiworapongsa T., et al. Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. Histopathology 2006, 49:506-514.
85. Kim S.K., Romero R., Chaiworapongsa T., et al. Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome. J Perinat Med 2009, 37:543-552.
86. Di Naro E., Cromi A., Ghezzi F., et al. Fetal thymic involution: a sonographic marker of the fetal inflammatory response syndrome. Am J Obstet Gynecol 2006, 194:153-159.
87. Kunzmann S., Glogger K., Been J.V., et al. Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep. Am J Obstet Gynecol 2010, 202(476):e1-e9.
88. Thomas W., Seidenspinner S., Kawczynska-Leda N., et al. Systemic fetal inflammation and reduced concentrations of macrophage migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants. Am J Obstet Gynecol 2008, 198(64):e1-e6.