The case of an sry-negative XX male pug with an inguinal gonad

Reproduction in Domestic Animals

Volumn 45, Issue 4, 2010, Pages 743-745

  Rota, A ^a   Cucuzza, A Starvaggi ^a   Iussich, S ^a   DeLorenzi, L ^b   Parma, P ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; CASE REPORT; CHROMOSOME DISORDER; CRYPTORCHISM; DOG; DOG DISEASE; FEMALE; GENETICS; HISTOLOGY; KLINEFELTER SYNDROME; MALE; PATHOLOGY; SEX DIFFERENTIATION DISORDER; SRY GENE; TESTIS; UTERUS;

ANIMALS; CRYPTORCHIDISM; DISORDERS OF SEX DEVELOPMENT; DOG DISEASES; DOGS; FEMALE; GENES, SRY; KLINEFELTER SYNDROME; MALE; SEX CHROMOSOME DISORDERS; TESTIS; UTERUS;

CANIS FAMILIARIS;

EID: 77956096404     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2008.01335.x     Document Type: Article

References (18)

1. Bishop CE, Whitworth DJ, Qin Y, Agoulnik AI, Agoulnik IU, Harrison WR, Behringer RR, Overbeek PA. A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet 2000, 26:490-494.
2. Bouayed Abdelmoula N, Portnoi MF, Keskes L, Recan D, Bahloul A, Boudawara T, Saad A, Rebai T. Skewed X-chromosome inactivation pattern in SRY positive XX maleness: a case report and review of literature. Ann Genet 2003, 46:11-18.
3. De Lorenzi L, Groppetti D, Arrighi S, Pujar S, Nicoloso L, Molteni L, Pecile A, Cremonesi F, Parma P, Meyers-Wallen V. Mutations in the RSPO1 coding region are not the main cause of canine SRY-negative XX sex reversal in several breeds. Sex Dev 2008, 2:84-95.
4. Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 2003, 24:466-487.
5. Hubler M, Hauser B, Meyers-Wallen VN, Arnold S. Sry-negative XX true hermaphrodite in a basset hound. Theriogenology 1999, 51:1391-1403.
6. Kuiper H, Bunck C, Günzel-Apel AR, Drögemüller C, Hewicker-Trautwein M, Distl O. SRY-negative XX sex reversal in a Jack Russell Terrier: a case report. Vet J 2005, 169:116-117.
7. Melniczek JR, Dambach D, Prociuk U, Jezyk PF, Henthorn P, Patterson DF, Giger U. Sry-negative XX sex reversal in a family of Norwegian Elkhounds. J Vet Intern Med 1999, 13:564-569.
8. Meyers-Wallen VN. Genetics of sexual differentiation and anomalies in dogs and cats. J Reprod Fertil Suppl 1993, 47:441-452.
9. Meyers-Wallen VN. Inherited abnormalities of sexual development in dogs and cats. Recent Advances in Small Animal Reproduction 2001, http://www.ivis.org, Concannon PWEngland GVerstegen J. In, eds, International Veterinary Information Service, Ithaca, NY, Available at, Document N. A1217.0901
10. Meyers-Wallen VN, Patterson DF. XX sex reversal in the American cocker spaniel dog: phenotypic expression and inheritance. Hum Gen 1988, 80:23-30.
11. Meyers-Wallen VN, Donahoe PK, Manganaro T, Patterson DF. Müllerian inhibiting substance in sex-reversed dogs. Biol Reprod 1987, 37:1015-1022.
12. Meyers-Wallen VN, Schlafer D, Barr I, Lovell-Badge R, Keyzner A. Sry-Negative XX sex reversal in purebred dogs. Mol Reprod Dev 1999, 53:266-273.
13. Pailhoux E, Vigier B, Chaffaux S, Servel N, Taourit S, Furet JP, Fellous M, Grosclaude F, Cribiu EP, Cotinot C, Vaiman D. A 11.7-kb deletion triggers intersexuality and polledness in goats. Nat Genet 2001, 29:453-458.
14. Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G. R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 2006, 38:1304-1309.
15. Sommer MM, Meyers-Wallen VN. XX True hermaphroditism in a dog. J Am Vet Med Assoc 1991, 198:435-438.
16. Stewart RW, Menges RW, Selby LA, Rhoades JD, Crenshaw DB. Canine intersexuality in a pug breeding kennel. Cornell Vet 1972, 62:464-473.
17. Vidal VP, Chaboissier MC, de Rooij DG, Schedl A. Sox9 induces testis development in XX transgenic mice. Nat Genet 2001, 28:216-217.
18. Wilhelm D, Koopman P. The making of maleness: towards an integrated view of male sexual development. Nat Rev Genet 2006, 7:620-631.