Controlling selectivity and enhancing yield of flavonoid glycosides in recombinant yeast

Bioprocess and Biosystems Engineering

Volumn 33, Issue 7, 2010, Pages 863-871

  Werner, Sean R ^a   Morgan, John A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Glyceraldehyde 3 phosphate dehydrogenase promoter; Glycosyltransferase; Naringenin glycoside; Orotic acid

Indexed keywords

CULTURE MEDIUM; DOSE-DEPENDENT MANNER; FLAVONOID GLYCOSIDES; FLAVONOIDS; GLUCOSE CONTENT; GLUCOSYLTRANSFERASES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GLYCOSYLTRANSFERASE; MODEL SUBSTRATES; MONOPHOSPHATES; NARINGENIN GLYCOSIDE; NATURAL SWEETENER; OROTIC ACID; RECOMBINANT YEAST; SACCHAROMYCES CEREVISIAE; SUBSTRATE CONCENTRATIONS; UDP-GLUCOSE; WHOLE CELL BIOCATALYSTS; YEAST SYSTEMS;

BIOCHEMISTRY; CARBOXYLIC ACIDS; CELL CULTURE; GLUCOSE; SUBSTRATES; YEAST;

ACIDS;

FLAVONE GLUCOSYLTRANSFERASE; FLAVONOID GLYCOSIDE; GLUCOSE; GLUCOSYLTRANSFERASE; NARINGENIN; NARINGENIN 4' O GLUCOSIDE; NARINGENIN 7 O GLUCOSIDE; OROTIC ACID; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE;

ARTICLE; BIOCATALYSIS; BIOTECHNOLOGICAL PRODUCTION; BIOTRANSFORMATION; CARNATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; FUNGAL METABOLISM; FUNGUS MUTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CELL CULTURE TECHNIQUES; FLAVONES; GENETIC ENHANCEMENT; GLYCOSIDES; SACCHAROMYCES CEREVISIAE;

DIANTHUS CARYOPHYLLUS; SACCHAROMYCES CEREVISIAE;

EID: 77956061937     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-010-0409-7     Document Type: Article

References (18)

1. V Kren L Martinkova 2001 Glycosides in medicine: the role of glycosidic residue in biological activity Curr Med Chem 8 1303 1328 1:CAS:528: DC%2BD3MXmt1ShtbY%3D
2. EK Lim DA Ashford B Hou RG Jackson DJ Bowles 2004 Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides Biotechnol Bioeng 87 623 631 10.1002/bit.20154 1:CAS:528:DC%2BD2cXnt1Wjtbw%3D (Pubitemid 39295407)
3. J Kim B Kim Y Park, et al. 2006 Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana Biosci Biotechnol Biochem 70 1471 1477 10.1271/bbb.60006 1:CAS:528:DC%2BD28XmslWkurk%3D (Pubitemid 43961826)
4. JH Kim KH Shin JH Ko JH Ahn 2006 Glucosylation of flavonols by Escherichia coli expressing glucosyltransferase from rice (Oryza sativa) J Biosci Bioeng 102 135 137 10.1263/jbb.102.135 1:CAS:528:DC%2BD28XhtFSjtr%2FF (Pubitemid 44486923)
5. EK Lim DA Ashford DJ Bowles 2006 The synthesis of small-molecule rhamnosides through the rational design of a whole-cell biocatalysis system Chembiochem 7 1181 1185 10.1002/cbic.200600193 1:CAS:528:DC%2BD28Xos1Knu7o%3D (Pubitemid 44230841)
6. MG Willits M Giovanni RTN Prata, et al. 2004 Bio-fermentation of modified flavonoids: an example of in vivo diversification of secondary metabolites Phytochemistry 65 31 41 10.1016/j.phytochem.2003.10.005 1:CAS:528: DC%2BD3sXpvFynsrc%3D (Pubitemid 38155890)
7. SR Werner JA Morgan 2009 Expression of a Dianthus flavonoid glucosyltransferase in Saccharomyces cerevisiae for whole-cell biocatalysis J Biotechnol 142 233 241 10.1016/j.jbiotec.2009.05.008 1:CAS:528: DC%2BD1MXoslSis74%3D
8. X Han D Ren P Fan T Shen H Lou 2008 Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells Eur J Pharmacol 581 47 53 10.1016/j.ejphar.2007.11.048 1:CAS:528:DC%2BD1cXhsVCmsb4%3D
9. Horowitz RM, Gentili B (1963) Dihydrochalcone derivatives and their use as sweetening agents. US Pat. 3,087,821
10. Westall EB, Messing AW (1977) Salts of dihydrochalcone derivatives and their use as sweeteners. US Pat. 3,984,394
11. HX Jiang JA Morgan 2004 Optimization of an in vivo plant P450 monooxygenase system in Saccharomyces cerevisiae Biotechnol Bioeng 85 130 137 10.1002/bit.10867 1:CAS:528:DC%2BD2cXitlelug%3D%3D (Pubitemid 38141114)
12. D Mumberg R Muller M Funk 1995 Yeast vector for the controlled expression of heterologous proteins in different genetic backgrounds Gene 156 119 122 10.1016/0378-1119(95)00037-7 1:CAS:528:DyaK2MXkvVamsb4%3D
13. Gietz RD, Woods RA (2002) Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. In: Guthrie C, Fink G (eds) Methods in enzymology, vol 350. Academic Press, San Diego, pp 87-96
14. Y Ni RR Chen 2004 Accelerating whole-cell biocatalysis by reducing outer membrane permeability barrier Biotechnol Bioeng 87 804 811 10.1002/bit.20202 1:CAS:528:DC%2BD2cXnsVejt7Y%3D (Pubitemid 39264650)
15. S Koizumi T Endo K Tabata A Ozaki 1998 Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria Nat Biotechnol 16 847 850 10.1038/nbt0998-847 1:CAS:528:DyaK1cXlvFWks7k%3D
16. E Leonard Y Yan ZL Fowler, et al. 2008 Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids Mol Pharm 5 257 265 10.1021/mp7001472 1:CAS:528:DC%2BD1cXjt1Wru7k%3D (Pubitemid 351579129)
17. LF Hernandez JC Espinosa M Fernandez-Gonzalez A Briones 2003 beta-Glucosidase activity in a Saccharomyces cerevisiae wine strain Int J Food Microbiol 80 171 176 10.1016/S0168-1605(02)00149-6 1:CAS:528: DC%2BD38XnvVKhs7Y%3D
18. H McMahon BW Zoecklein K Fugelsang Y Jasinski 1999 Quantification of glycosidase activities in selected yeasts and lactic acid bacteria J Ind Microbiol Biotechnol 23 198 203 10.1038/sj.jim.2900720 1:CAS:528: DyaK1MXntlOit7o%3D