Identification of cultivation condition to produce correctly folded form of a malaria vaccine based on Plasmodium falciparum merozoite surface protein-1 in Escherichia coli

Bioprocess and Biosystems Engineering

Volumn 33, Issue 6, 2010, Pages 719-730

  Mazumdar, Suman ^a   Sachdeva, Suraksha ^a   Chauhan, Virander S ^a   Yazdani, Syed Shams ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

Characterization; Malaria vaccine; Merozoite surface protein 1; Process development; Recombinant Escherichia coli

Indexed keywords

BIOPHYSICAL CHARACTERIZATION; CELL LYSATES; CULTIVATION CONDITIONS; EXPRESSION LEVELS; FEEDING STRATEGIES; GENE CONSTRUCTS; HIGH QUALITY; ION EXCHANGE CHROMATOGRAPHY; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN-1; MEROZOITE SURFACE PROTEINS; METAL AFFINITY; PARASITE-; PLASMODIUM FALCIPARUM; PROCESS DEVELOPMENT; PURIFICATION PROCEDURES; RECOMBINANT ESCHERICHIA COLI; SYNTHETIC GENES; YEAST EXTRACTS;

CHROMATOGRAPHIC ANALYSIS; CULTIVATION; ESCHERICHIA COLI; ION CHROMATOGRAPHY; ION EXCHANGE; OPTIMIZATION; PROTEINS; PURIFICATION; VACCINES;

GENE EXPRESSION;

MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 1; METAL; RECOMBINANT PROTEIN;

ARTICLE; BACTERIUM CULTURE; BACTERIUM MUTANT; BATCH FERMENTATION; BINDING AFFINITY; BIOPHYSICS; BIOREACTOR; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FED BATCH FERMENTATION; FERMENTATION MEDIUM; GENE CONSTRUCT; GENE EXPRESSION; ION EXCHANGE CHROMATOGRAPHY; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PURIFICATION; VACCINE PRODUCTION; YEAST; BIOSYNTHESIS; CHEMISTRY; FERMENTATION; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; PROTEIN TERTIARY STRUCTURE;

ESCHERICHIA COLI; FERMENTATION; MALARIA VACCINES; MEROZOITE SURFACE PROTEIN 1; PLASMODIUM FALCIPARUM; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; YEASTS;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM;

EID: 77956060056     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-009-0394-x     Document Type: Article

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