Cyanobacterial (blue-green algae) toxins

Veterinary Toxicology

Volumn , Issue , 2007, Pages 714-724

  Puschner, Birgit ^a   Humbert, Jean François ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956057863     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012370467-2/50156-5     Document Type: Chapter

References (138)

1. Aas P, Eriksen S, Kolderup J, et al. Enhancement of acetylcholine release by homoanatoxin-a from. Oscillatoria formosa. Environ Toxicol Pharmacol 1996, 2:223-232.
2. Agrawal MK, Ghosh SK, Bagchi D, et al. Occurrence of microcystin-containing toxic water blooms in central India. J Microbiol Biotechnol 2006, 16:212-218.
3. Amar M, Thomas P, Johnson C, et al. Agonist pharmacology of the neuronal alpha 7 nicotinic receptor expressed in Xenopus oocytes. FEBS Lett 1993, 327:284-288.
4. Anagnostidis K, Komarek J Modern approach to the classification system of cyanophytes. Arch Hydrobiol Suppl 7, Algol Stud 1985, 38/39:291-302.
5. Atkins R, Rose T, Brown RS, et al. The Microcystis cyanobacteria bloom in the Swan River-February 2000. Water Sci Technol 2001, 43:107-114.
6. Azevedo SM, Carmichael WW, Jochimsen EM, et al. Human intoxication by microcystins during renal dialysis treatment in Caruaru, Brazil. Toxicology 2002, 181-182:441-446.
7. Ballot A, Krienitz L, Kotut K, et al. Cyanobacteria and cyanobacterial toxins in three alkaline rift valley lakes of Kenya-Lakes Bogoria, Nakuru and Elmenteita. J Plankton Res 2004, 26:925-935.
8. Banker R, Carmeli S, Hadas O, et al. Identification of cylindrospermopsin in Aphanizomenon ovalisporum (Cyanophyceae) isolated from lake Kinneret, Israel. J Phycol 1997, 33:613-616.
9. Barik J, Wonnacott S Indirect modulation by alpha 7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices, interaction with glutamate and GABA syste. Mol Pharmacol 2006, 69:618-628.
10. Bartram J, Carmichael WW, Chorus I, et al. Introduction. Toxic Cyanobacteria in Water - a Guide to Their Public Health Consequences, Monitoring and Management 1999, 1-14. E & FN Spon, London/New York. I. Chorus, J. Bartram (Eds.).
11. Beltran EC, Neilan BA Geographical segregation of the neurotoxin-producing cyanobacterium. Anabaena circinalis. Appl Environ Microbiol 2000, 66:4468-4474.
12. Bogialli S, Bruno M, Curini R, et al. Simple assay for analyzing five microcystins and nodularin in fish muscle tissue, hot water extraction followed by liquid chromatography-tandem mass spectrome. J Agric Food Chem 2005, 53:6586-6592.
13. Braun A, Pfeiffer T Cyanobacterial blooms as the cause of a Pleistocene large mammal assemblage. Paleobiology 2002, 28:134-139.
14. Briand JF, Jacquet S, Bernard C, et al. Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems. Vet Res 2003, 34:361-377.
15. Briand JF, Jacquet S, Flinois C, et al. Variations in the microcystin production of Planktothrix rubescens (Cyanobacteria) assessed from a four-year survey of Lac du Bourget (France) and from la. Microb Ecol 2005, 50:418-428.
16. Carbis CR, Simons JA, Mitchell GF, et al. Abiochemical profile for predicting the chronic exposure of sheep to Microcystis aeruginosa, an hepatotoxic species of blue-green alga. Res Vet Sci 1994, 57:310-316.
17. Carmichael WW, Gorham PR, Biggs DF Two laboratory case studies on oral toxicity to calves of freshwater cyanophyte (blue-green-alga) Anabaena flos-aquae Nrc-44-1. Can Vet J 1977, 18:71-75.
18. Carmichael WW, Evans WR, Yin QQ, et al. Evidence for paralytic shellfish poisons in the freshwater cyanobacterium Lyngbya wollei (Farlow ex Gomont) comb. nov. Appl Environ Microbiol 1997, 63:3104-3110.
19. Carmichael WW, Azevedo SM, An JS, et al. Human fatalities from cyanobacteria, chemical and biological evidence for cyanotoxins. Environ Health Perspect 2001, 109:663-668.
20. Carmichael WW, Li R Cyanobacteria toxins in the Salton Sea. Saline Ecosystems 2006, 2:5.
21. Cook WO, Beasley VR, Lovell RA, et al. Consistent inhibition of peripheral cholinesterases by neurotoxins from the fresh-water cyanobacterium Anabaena flos-aquae-studies of ducks, swine, mice a. Environ Toxicol Chem 1989, 8:915-922.
22. Cook WO, Dellinger JA, Singh SS, et al. Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a (s) or paraoxon. Toxicol Lett 1989, 49:29-34.
23. Cook WO, Iwamoto GA, Schaeffer DJ, et al. Pathophysiologic effects of anatoxin-a (s) in anaesthetized rats, the influence of atropine and artificial respiration. Pharmacol Toxicol 1990, 67:151-155.
24. Devic E, Li DH, Dauta A, et al. Detection of anatoxin-a (s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases. Appl Environ Microbiol 2002, 68:4102-4106.
25. DeVries SE, Galey FD, Namikoshi M, et al. Clinical and pathologic findings of blue-green algae (Microcystis aeruginosa) intoxication in a dog. J Vet Diagn Invest 1993, 5:403-408.
26. Dietrich D, Hoeger S Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements) , a reasonable or misguided approach?. Toxicol Appl Pharmacol 2005, 203:273-279.
27. Ding WX, Nam Ong C Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol Lett 2003, 220:1-7.
28. Done SH, Bain M Hepatic necrosis in sheep associated with ingestion of blue-green algae. Vet Rec 1993, 133:600.
29. Downing TG, Sember CS, Gehringer MM, et al. Medium N,P ratios and specific growth rate comodulate microcystin and protein content in Microcystis aeruginosa PCC7806 and M. aeruginosa UV027. Microb Ecol 2005, 49:468-473.
30. Edwards C, Beattie KA, Scrimgeour CM, et al. Identification of anatoxin-a in benthic cyanobacteria (blue-green algae) and in associated dog poisonings at Loch Insh, Scotland. Toxicon 1992, 30:1165-1175.
31. Falconer IR, Buckley T, Runnegar MTC Biological halflife, organ distribution and excretion of I-125 labeled toxic peptide from the blue-green-alga. Microcystis aeruginosa. Aust J Biol Sci 1986, 39:17-21.
32. Falconer IR, Smith JV, Jackson AR, et al. Oral toxicity of a bloom of the cyanobacterium Microcystis aeruginosa administered to mice over periods up to 1 year. J Toxicol Environ Health 1988, 24:291-305.
33. Falconer IR, Yeung DS Cytoskeletal changes in hepatocytes induced by microcystis toxins and their relation to hyperphosphorylation of cell proteins. Chem Biol Interact 1992, 81:181-196.
34. Falconer IR, Burch MD, Steffensen DA, et al. Toxicity of the blue-green algae (Cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as animal model for human injury and risk asse. Environ Toxic Water 1994, 9:131-139.
35. Falconer IR, Humpage AR Health risk assessment of cyanobacterial (blue-green algal) toxins in drinking water. Int J Environ Res Public Health 2005, 2:43-50.
36. Fastner J, Heinze R, Humpage AR, et al. Cylindrospermopsin occurrence in two German lakes and preliminary assessment of toxicity and toxin production of Cylindrospermopsis raciborskii (Cyanobact. Toxicon 2003, 42:313-321.
37. Fawell JK, James CP, James HA Toxins from Blue-Green Algae, Toxicological Assessment of Microcystin-LR and a Method for Its Determination in Water 1994, 1-46. Water Research Centre, Medmenham, UK.
38. Fischer WJ, Hitzfeld BC, Tencalla F, et al. Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykis. Toxicol Sci 2000, 54:365-373.
39. Fitzgerald SD, Poppenga RH Toxicosis due to microcystin hepatotoxins in three Holstein heifers. J Vet Diagn Invest 1993, 5:651-653.
40. Francis G Poisonous Australian Lake. Nature 1878, 18:11-12.
41. Frias HV, Mendes MA, Cardozo KH, et al. Use of electrospray tandem mass spectrometry for identification of microcystins during a cyanobacterial bloom event. Biochem Biophys Res Commun 2006, 344:741-746.
42. Fromme H, Kohler A, Krause R, et al. Occurrence of cyanobacterial toxins-microcystins and anatoxin-a-in Berlin water bodies with implications to human health and regulations. Environ Toxicol 2000, 15:120-130.
43. Furey A, Crowley J, Hamilton B, et al. Strategies to avoid the mis-identification of anatoxin-a using mass spectrometry in the forensic investigation of acute neurotoxic poisoning. J Chromatogr A 2005, 1082:91-97.
44. Furey A, Crowley J, Shuilleabhain AN, et al. The first identifi-cation of the rare cyanobacterial toxin, homoanatoxin-a, in Ireland. Toxicon 2003, 41:297-303.
45. Galey FD, Beasley VR, Carmichael WW, et al. Blue-green algae (Microcystis aeruginosa) hepatotoxicosis in dairy cows. Am J Vet Res 1987, 48:1415-1420.
46. Gehringer MM, Downs KS, Downing TG, et al. An investigation into the effect of selenium supplementation on microcystin hepatotoxicity. Toxicon 2003, 41:451-458.
47. Gehringer MM, Govender S, Shah M, et al. An investigation of the role of vitamin E in the protection of mice against microcystin toxicity. Environ Toxicol 2003, 18:142-148.
48. Griffiths DJ, Saker ML The palm island mystery disease 20 years on, a review of research on the cyanotoxin cylindrospermopsin. Environ Toxicol 2003, 18:78-93.
49. Gugger M, Lenoir S, Berger C, et al. First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 2005, 45:919-928.
50. Gunn GJ, Rafferty AG, Rafferty GC, et al. Fatal canine neurotoxicosis attributed to blue-green algae (cyanobacteria) . Vet Rec 1992, 130:301-302.
51. Harding WR, Rowe N, Wessels JC, et al. Death of a dog attributed to the cyanobacterial (blue-green algal) hepatotoxin nodularin in South Africa. J South Afr Vet Assoc-Tydskrif Van Die Suid-Afrikaanse Veterinere Vereniging 1995, 66:256-259.
52. Hawkins PR, Chandrasena NR, Jones GJ, et al. Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake. Toxicon 1997, 35:341-346.
53. Heinze R Toxicity of the cyanobacterial toxin microcystin-LR to rats after 28 days intake with the drinking water. Environ Toxicol 1998, 14:57-60.
54. Henriksen P, Carmichael WW, An JS, et al. Detection of an anatoxin-a (s) -like anticholinesterase in natural blooms and cultures of cyanobacteria/blue-green algae from Danish lakes and in the stomach. Toxicon 1997, 35:901-903.
55. Hermansky SJ, Casey PJ, Stohs SJ Cyclosporin A-a chemoprotectant against microcystin-LR toxicity. Toxicol Lett 1990, 54:279-286.
56. Hermansky SJ, Wolff SN, Stohs SJ Use of rifampin as an effective chemoprotectant and antidote against microcystin-LR toxicity. Pharmacology (Basel) 1990, 41:231-236.
57. Hermansky SJ, Stohs SJ, Eldeen ZM, et al. Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice. J Appl Toxicol 1991, 11:65-74.
58. Hitzfeld BC, Lampert CS, Spaeth N, et al. Toxin production in cyanobacterial mats from ponds on the McMurdo ice shelf, Antarctica. Toxicon 2000, 38:1731-1748.
59. Hooser SB, Beasley VR, Waite LL, et al. Actin filament alterations in rat hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga,. Microcystis aeruginosa. Vet Pathol 1991, 28:259-266.
60. Hooser S B, Kuhlenschmidt MS, Dahlem AM, et al. Uptake and subcellular localization of titrated dihydro-microcystin-LR in rat liver. Toxicon 1991, 29:589-601.
61. Humpage AR, Rositano J, Bretag AH, et al. Paralytic shellfish poisons from Australian cyanobacterial blooms. Aust J Mar Fresh Res 1994, 45:761-771.
62. Humpage AR., Falconer IR Microcystin-LR and liver tumor promotion, Effects on cytokinesis, ploidy, and apoptosis in cultured hepatocytes. Environ Toxicol 1999, 14:61-75.
63. Hyde EG, Carmichael WW Anatoxin-a (s) , a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7) . J Biochem Toxicol 1991, 6:195-1201.
64. Ito E, Kondo F, Harada K Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon 1997, 35:231-239.
65. Ito E, Kondo F, Harada K First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon 2000, 38:37-48.
66. Ito E, Kondo F, Harada K Intratracheal administration of microcystin-LR, and its distribution. Toxicon 2001, 39:265-271.
67. James KJ, Sherlock IR, Stack MA Anatoxin-a in Irish freshwater and cyanobacteria, determined using a new fluorimetric liquid chromatographic method. Toxicon 1997, 35:963-971.
68. James KJ, Furey A, Sherlock IR, et al. Sensitive determination of anatoxin-a, homoanatoxin-a and their degradation products by liquid chromatography with fluorimetric detection. J Chromatogr A 1998, 798:147-157.
69. Kaas H, Henriksen P Saxitoxins (PSP toxins) in Danish lakes. Water Res 2000, 34:2089-2097.
70. Karlsson KM, Kankaanpaa H, Huttunen M, et al. First observation of microcystin-LR in pelagic cyanobacterial blooms in the northern Baltic Sea. Harmful Algae 2005, 4:163-166.
71. Karlsson KM, Spoof LE, Meriluoto JA Quantitative LC-ESI-MS analyses of microcystins and nodularin-R in animal tissue-matrix effects and method validation. Environ Toxicol 2005, 20:381-389.
72. Kerr LA, McCoy CP, Eaves D Blue-green algae toxicosis in five dairy cows. J Am Vet Med Assoc 1987, 191:829-830.
73. Kondo F, Matsumoto H, Yamada S, et al. Detection and identi-fication of metabolites of microcystins formed in vivo in mouse and rat livers. Chem Res Toxicol 1996, 9:1355-1359.
74. Krienitz L, Ballot A, Kotut K, et al. Contribution of hot spring cyanobacteria to the mysterious deaths of Lesser Flamingos at Lake Bogoria, Kenya. FEMS Microbiol Ecol 2003, 43:141-148.
75. Kuiper-Goodman T, Falconer I, Fitzgerald J Human health aspects. Toxic Cyanobacteria in Water - a Guide to Their Public Health Consequences, Monitoring and Management 1999, 113-153. World Health Organization, London, UK. I. Chorus, J. Bartram (Eds.).
76. Lawton LA, Edwards C, Beattie KA, et al. Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal. Nat Toxins 1995, 3:50-57.
77. Lopez Rodas V, Costas E Preference of mice to consume Microcystis aeruginosa (toxin-producing cyanobacteria) , a possible explanation for numerous fatalities of livestock and wil. Res Vet Sci 1999, 67:107-110.
78. Luukkainen R, Namikoshi M, Sivonen K, et al. Isolation and identification of 12 microcystins from four strains and two bloom samples of Microcystis spp., structure of a new hepatotoxin. Toxicon 1994, 32:133-139.
79. Mahmood NA, Carmichael WW The pharmacology of anatoxin-a (s) , a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17. Toxicon 1986, 24:425-434.
80. Mahmood NA, Carmichael WW, Pfahler D Anticholinesterase poisonings in dogs from a cyanobacterial (blue-green algae) bloom dominated by. Anabaena flos-aquae. Am J Vet Res 1988, 49:500-503.
81. Maizels M, Budde WL A LC/MS method for the determination of cyanobacteria toxins in water. Anal Chem 2004, 76:1342-1351.
82. Matsunaga S, Moore RE, Niemczura WP, et al. Anatoxin-a (s) , a potent anticholinesterase from. Anabaena flos-aquae. J Am Chem Soc 1989, 111:8021-8023.
83. McDermott CM, Nho CW, Howard W, et al. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon 1998, 36:1981-1996.
84. McElhiney J, Lawton LA Detection of the cyanobacterial hepatotoxins microcystins. Toxicol Appl Pharmacol 2005, 203:219-230.
85. Mereish KA, Solow R Interaction of microcystin-LR with SuperChar, water decontamination and therapy. J Toxicol Clin Toxicol 1989, 27:271-280.
86. Mez K, Beattie KA, Codd GA, et al. Identification of microcystin in benthic cyanobacteria linked to cattle deaths on alpine pastures in Switzerland. Eur J Phycol 1997, 32:111-117.
87. Milutinovic A, Zivin M, Zorc-Pleskovic R, et al. Nephrotoxic effects of chronic administration of microcystins-LR and YR. Toxicon 2003, 42:281-288.
88. Molica RJR, Oliveira EJA, Carvalho PVC, et al. Occurrence of saxitoxins and an anatoxin-a (s) -like anticholinesterase in a Brazilian drinking water supply. Harmful Algae 2005, 4:743-753.
89. Monserrat JM, Yunes JS, Bianchini A Effects of Anabaena spiroides (cyanobacteria) aqueous extracts on the acetylcholinesterase activity of aquatic species. Environ Toxicol Chem 2001, 20:1228-1235.
90. Mur LR, Skulberg OM, Utkilen H Cyanobacteria in the environment. Toxic Cyanobacteria in Water - a Guide to Their Public Health Consequences, Monitoring and Management 1999, 15-40. E & FN Spon, London/New York. I. Chorus, J. Bartram (Eds.).
91. Naegeli H, Sahin A, Braun U, et al. Sudden deaths of cattle on Alpine pastures in South-Eastern Switzerland. Schweiz Archiv Tierheilk 1997, 139:201-209.
92. Namikoshi M, Murakami T, Fujiwara T, et al. Biosynthesis and transformation of homoanatoxin-a in the cyanobacterium Raphidiopsis mediterranea Skuja and structures of three new homologues. Chem Res Toxicol 2004, 17:1692-1696.
93. Ndetei R, Muhandiki VS Mortalities of Lesser Flamingos in Kenyan Rift Valley saline lakes and the implications for sustainable management of the lakes. Lakes Reservoirs Res Manag 2005, 10:51-58.
94. Norris RL, Eaglesham GK, Pierens G, et al. Deoxycylindrospermopsin, an analog of cylindrospermopsin from. Cylindrospermopsis raciborskii. Environ Toxicol 1999, 14:163-165.
95. Odriozola E, Ballabene N, Salamanco A Poisoning in cattle caused by blue-green algae. Rev Argent Microbiol 1984, 16:219-224.
96. Ohtani I, Moore RE, Runnegar MTC Cylindrospermopsin, a potent hepatotoxin from the blue-green alga. Cylindrospermopsis raciborskii. J Am Chem Soc 1992, 114:7941-7942.
97. Oliver RL, Gant GG Freshwater blooms. The ecology of cyanobacteria 1999, 149-194. Kluwer Academic Publishers, Dordrecht, The Netherlands. B.A. Whitton, M. Potts (Eds.).
98. Onodera H, Oshima Y, Henriksen P, et al. Confirmation of anatoxin-a (s) , in the cyanobacterium Anabaena lemmermannii, as the cause of bird kills in Danish lakes. Toxicon 1997, 35:1645-1648.
99. Orr PT, Jones GJ Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures. Limnol Oceanogr 1998, 43:1604-1614.
100. Orr PT, Jones GJ, Hunter RA, et al. Ingestion of toxic Microcystis aeruginosa by dairy cattle and the implications for microcystin contamination of milk. Toxicon 2001, 39:1847-1854.
101. Orr PT, Jones GJ, Hunter RA, et al. Exposure of beef cattle to sub-clinical doses of Microcystis aeruginosa, toxin bioaccumulation, physiological effects and human health risk assessment. Toxicon 2003, 41:613-620.
102. Ott JL, Carmichael WW LC/ESI/MS method development for the analysis of hepatotoxic cyclic peptide microcystins in animal tissues. Toxicon 2006, 47:734-741.
103. Park HD, Iwami C, Watanabe MF, et al. Temporal variabilities of the concentrations of intra-and extracellular microcystin and toxic microcystis species in a hypertrophic lake, Lake Suwa, Japan (19. Environ Toxic Water 1998, 13:61-72.
104. Pflugmacher S, Wiegand C, Oberemm A, et al. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR, the first step of detoxication. BBA-Gen 1998, 1425:527-533.
105. Puschner B, Galey FD, Johnson B, et al. Blue-green algae toxicosis in cattle. J Am Vet Med Assoc 1998, 213:1571-1605.
106. Rao PV, Gupta N, Bhaskar AS, et al. Toxins and bioactive compounds from cyanobacteria and their implications on human health. J Environ Biol 2002, 23:215-224.
107. Rao PV, Jayaraj R, Bhaskar AS Protective efficacy and the recovery profile of certain chemoprotectants against lethal poisoning by microcystin-LR in mice. Toxicon 2004, 44:723-730.
108. Reynolds CS, Walsby AE Water-blooms. Biol Rev 1975, 50:437-481.
109. Rinehart KL, Namikoshi M, Choi BW Structure and biosynthesis of toxins from blue-green-algae (cyanobacteria) . J Appl Phycol 1994, 6:159-176.
110. Rippka R, Deruelles J, Waterbury JB, et al. Generic assignments, strain histories and properties of pure cultures of cyanobacteria. J Gen Microbiol 1979, 111:1-61.
111. Robinson NA, Pace JG, Matson CF, et al. Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice. J Pharmacol Exp Ther 1991, 256:176-182.
112. Runnegar MTC, Falconer IR, Silver J Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga. Microcystis aeruginosa. Naunyn Schmiedebergs Arch Pharmacol 1981, 317:268-272.
113. Runnegar MTC, Falconer IR, Buckley T, et al. Lethal potency and tissue distribution of I-125 labeled toxic peptides from the blue-green-alga. Microcystis aeruginosa. Toxicon 1986, 24:506-509.
114. Runnegar MTC, Jackson ARB, Falconer IR Toxicity to mice and sheep of a bloom of the cyanobacterium (blue green-alga). Anabaena circinalis. Toxicon 1988, 26:599-602.
115. Runnegar MT, Kong S, Berndt N Protein phosphatase inhibition and in vivo hepatotoxicity of microcystins. Am J Physiol 1993, 265:G224-G230.
116. Saker ML, Thomas AD, Norton JH Cattle mortality attributed to the toxic cyanobacterium Cylindrospermopsis raciborskii in an outback region of north Queensland. Environ Toxicol 1999, 14:179-182.
117. Saker ML, Griffiths DJ Occurrence of blooms of the cyanobacterium Cylindrospermopsis raciborskii (Woloszynska) Seenayya and Subba Raju in a north Queensland domestic water suppl. Mar Freshwater Res 2001, 52:907-915.
118. Schaeffer DJ, Malpas PB, Barton LL Risk assessment of microcystin in dietary. Aphanizomenon flos-aquae. Ecotoxicol Environ Safe 1999, 44:73-80.
119. Seawright AA, Nolan CC, Shaw GR, et al. The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska) . Environ Toxicol 1999, 14:135-142.
120. Shaw GR, Seawright AA, Moore MR, et al. Cylindrospermopsin, a cyanobacterial alkaloid, evaluation of its toxicologic activity. Ther Drug Monit 2000, 22:89-92.
121. Sivonen K, Himberg K, Luukkainen R, et al. Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland. Toxic Assess 1989, 4:339-352.
122. Sivonen K, Jones G Cyanobacterial toxins. Toxic Cyanobacteria in Water - a Guide to Their Public Health Consequences, Monitoring and Management 1999, 41-111. E & FN Spon, London/ New York. I. Chorus, J. Bartram (Eds.).
123. Skulberg OM, Carmichael WW, Andersen RA, et al. Investigations of a neurotoxic oscillatorialean strain (Cyanophyceae) and its toxin-isolation and characterization of homoanatoxin-A. Environ Toxicol Chem 1992, 11:321-329.
124. Spivak CE, Witkop B, Albuquerque EX Anatoxin-a, a novel, potent agonist at the nicotinic receptor. Mol Pharmacol 1980, 18:384-394.
125. Stevens DK, Krieger RI Effect of route of exposure and repeated doses on the acute toxicity in mice of the cyanobacterial nicotinic alkaloid anatoxin-a. Toxicon 1991, 29:134-138.
126. Sueoka E, Sueoka N, Okabe S, et al. Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. J Cancer Res Clin Oncol 1997, 123:413-419.
127. Thomas P, Stephens M, Wilkie G, et al. (_) -Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem 1993, 60:2308-2311.
128. Ueno Y, Nagata S, Tsutsumi T, et al. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by h. Carcinogenesis 1996, 17:1317-1321.
129. Van Buynder PG, Oughtred T, Kirkby B, et al. Nodularin uptake by seafood during a cyanobacterial bloom. Environ Toxicol 2001, 16:468-471.
130. Van Halderen A, Harding WR, Wessels JC, et al. Cyanobacterial (blue-green algae) poisoning of livestock in the Western Cape Province of South Africa. J S Afr Vet Assoc 1995, 66:260-264.
131. Warhurst AM, Raggett SL, McConnachie G L, et al. Adsorption of the cyanobacterial hepatotoxin microcystin-LR by a low-cost activated carbon from the seed husks of the pan-tropical tree,. Moringa oleifera. Sci Total Environ 1997, 207:207-211.
132. Welker M, von Dℏren H Cyanobacterial peptides-nature's own combinatorial biosynthesis. FEMS Microbiol Rev 2006, 38:530-563.
133. Wonnacott S, Swanson KL, Albuquerque EX, et al. Homoanatoxin, a potent analogue of anatoxin-A. Biochem Pharmacol 1992, 43:419-423.
134. Wonnacott S, Kaiser S, Mogg A, et al. Presynaptic nicotinic receptors modulating dopamine release in the rat striatum. Eur J Pharmacol 2000, 393:51-58.
135. Yang X, Boyer GL Couf in Ann Arbor, MI Occurrence of the cyanobacterial neurotoxin, anatoxin-a, in lower Great Lakes. Ann Arbor, MI. IAGLR Conf Program Abstract 2005, 48:203-204.
136. Zhang X, Nordberg A The competition of (-) -[3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different. Naunyn Schmiedebergs Arch Pharmacol 1993, 348:28-34.
137. Zhou L, Yu H, Chen K Relationship between microcystin in drinking water and colorectal cancer. Biomed Environ Sci 2002, 15:166-171.
138. Zweigenbaum JA, Henion JD, Beattie KA, et al. Direct analysis of microcystins by microbore liquid chromatography electrospray ionization ion-trap tandem mass spectrometry. J Pharm Biomed Anal 2000, 23:723-733.