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Volumn 84, Issue 18, 2010, Pages 9516-9532

A short N-terminal peptide motif on flavivirus nonstructural protein NS1 modulates cellular targeting and immune recognition

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1; MUTANT PROTEIN; NS1 PROTEIN, FLAVIVIRUS; RECOMBINANT PROTEIN; VIRULENCE FACTOR; VIRUS PROTEIN;

EID: 77956021590     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00775-10     Document Type: Article
Times cited : (53)

References (67)
  • 1
    • 23844474001 scopus 로고    scopus 로고
    • The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: Implications for viral infectivity
    • DOI 10.1128/JVI.79.17.11403-11411.2005
    • Alcon-LePoder, S., M. T. Drouet, P. Roux, M. P. Frenkiel, M. Arborio, A. M. Durand-Schneider, M. Maurice, I. Le Blanc, J. Gruenberg, and M. Flamand. 2005. The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity. J. Virol. 79:11403-11411. (Pubitemid 41170681)
    • (2005) Journal of Virology , vol.79 , Issue.17 , pp. 11403-11411
    • Alcon-LePoder, S.1    Drouet, M.-T.2    Roux, P.3    Frenkiel, M.-P.4    Arborio, M.5    Durand-Schneider, A.-M.6    Maurice, M.7    Le Blanc, I.8    Gruenberg, J.9    Flamand, M.10
  • 2
    • 33947505082 scopus 로고    scopus 로고
    • Secretion of flaviviral non-structural protein NS1: From diagnosis to pathogenesis
    • discussion 247-253
    • Alcon-LePoder, S., P. Sivard, M. T. Drouet, A. Talarmin, C. Rice, and M. Flamand. 2006. Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis. Novartis Found. Symp. 277:233-247; discussion 247-253.
    • (2006) Novartis Found. Symp. , vol.277 , pp. 233-247
    • Alcon-LePoder, S.1    Sivard, P.2    Drouet, M.T.3    Talarmin, A.4    Rice, C.5    Flamand, M.6
  • 6
    • 0022897789 scopus 로고
    • Chlorate - A potent inhibitor of protein sulfation in intact cells
    • Baeuerle, P. A., and W. B. Huttner. 1986. Chlorate - a potent inhibitor of protein sulfation in intact cells. Biochem. Biophys. Res. Commun. 141:870-877.
    • (1986) Biochem. Biophys. Res. Commun. , vol.141 , pp. 870-877
    • Baeuerle, P.A.1    Huttner, W.B.2
  • 8
    • 0032976035 scopus 로고    scopus 로고
    • Identification and analysis of truncated and elongated species of the flavivirus NS1 protein
    • Blitvich, B. J., D. Scanlon, B. J. Shiell, J. S. Mackenzie, and R. A. Hall. 1999. Identification and analysis of truncated and elongated species of the flavivirus NS1 protein. Virus Res. 60:67-79.
    • (1999) Virus Res. , vol.60 , pp. 67-79
    • Blitvich, B.J.1    Scanlon, D.2    Shiell, B.J.3    Mackenzie, J.S.4    Hall, R.A.5
  • 10
    • 38849203171 scopus 로고    scopus 로고
    • Defining the levels of secreted non-structural protein NS1 after West Nile virus infection in cell culture and mice
    • Chung, K. M., and M. S. Diamond. 2008. Defining the levels of secreted non-structural protein NS1 after West Nile virus infection in cell culture and mice. J. Med. Virol. 80:547-556.
    • (2008) J. Med. Virol. , vol.80 , pp. 547-556
    • Chung, K.M.1    Diamond, M.S.2
  • 12
    • 31144442443 scopus 로고    scopus 로고
    • Antibodies against West Nile virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms
    • Chung, K. M., G. E. Nybakken, B. S. Thompson, M. J. Engle, A. Marri, D. H. Fremont, and M. S. Diamond. 2006. Antibodies against West Nile virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms. J. Virol. 80:1340-1351.
    • (2006) J. Virol. , vol.80 , pp. 1340-1351
    • Chung, K.M.1    Nybakken, G.E.2    Thompson, B.S.3    Engle, M.J.4    Marri, A.5    Fremont, D.H.6    Diamond, M.S.7
  • 13
    • 34548176969 scopus 로고    scopus 로고
    • Antibody recognition of cell surface-associated NS1 triggers Fc-γ receptor-mediated phagocytosis and clearance of West Nile virus-infected cells
    • Chung, K. M., B. S. Thompson, D. H. Fremont, and M. S. Diamond. 2007. Antibody recognition of cell surface-associated NS1 triggers Fc-γ receptor-mediated phagocytosis and clearance of West Nile virus-infected cells. J. Virol. 81:9551-9555.
    • (2007) J. Virol. , vol.81 , pp. 9551-9555
    • Chung, K.M.1    Thompson, B.S.2    Fremont, D.H.3    Diamond, M.S.4
  • 14
    • 0033988280 scopus 로고    scopus 로고
    • α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum
    • Courageot, M. P., M. P. Frenkiel, C. D. Dos Santos, V. Deubel, and P. Despres. 2000. α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. J. Virol. 74:564-572.
    • (2000) J. Virol. , vol.74 , pp. 564-572
    • Courageot, M.P.1    Frenkiel, M.P.2    Dos Santos, C.D.3    Deubel, V.4    Despres, P.5
  • 15
    • 17644375905 scopus 로고    scopus 로고
    • Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: Construction and characterization of mutant viruses
    • Crabtree, M. B., R. M. Kinney, and B. R. Miller. 2005. Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: construction and characterization of mutant viruses. Arch. Virol. 150:771-786.
    • (2005) Arch. Virol. , vol.150 , pp. 771-786
    • Crabtree, M.B.1    Kinney, R.M.2    Miller, B.R.3
  • 16
    • 0028650344 scopus 로고
    • The NS1 protein of tick-borne encephalitis virus forms multimeric species upon secretion from the host cell
    • Crooks, A. J., J. M. Lee, L. M. Easterbrook, A. V. Timofeev, and J. R. Stephenson. 1994. The NS1 protein of tick-borne encephalitis virus forms multimeric species upon secretion from the host cell. J. Gen. Virol. 75:3453-3460.
    • (1994) J. Gen. Virol. , vol.75 , pp. 3453-3460
    • Crooks, A.J.1    Lee, J.M.2    Easterbrook, L.M.3    Timofeev, A.V.4    Stephenson, J.R.5
  • 17
    • 0025997355 scopus 로고
    • Recombinant baculoviruses expressing yellow fever virus E and NS1 proteins elicit protective immunity in mice
    • Despres, P., J. Dietrich, M. Girard, and M. Bouloy. 1991. Recombinant baculoviruses expressing yellow fever virus E and NS1 proteins elicit protective immunity in mice. J. Gen. Virol. 72:2811-2816.
    • (1991) J. Gen. Virol. , vol.72 , pp. 2811-2816
    • Despres, P.1    Dietrich, J.2    Girard, M.3    Bouloy, M.4
  • 18
    • 0025801963 scopus 로고
    • Characterization of yellow fever virus proteins E and NS1 expressed in Vero and Spodoptera frugiperda cells
    • Despres, P., M. Girard, and M. Bouloy. 1991. Characterization of yellow fever virus proteins E and NS1 expressed in Vero and Spodoptera frugiperda cells. J. Gen. Virol. 72:1331-1342.
    • (1991) J. Gen. Virol. , vol.72 , pp. 1331-1342
    • Despres, P.1    Girard, M.2    Bouloy, M.3
  • 19
    • 0037319970 scopus 로고    scopus 로고
    • B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
    • Diamond, M. S., B. Shrestha, A. Marri, D. Mahan, and M. Engle. 2003. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J. Virol. 77:2578-2586.
    • (2003) J. Virol. , vol.77 , pp. 2578-2586
    • Diamond, M.S.1    Shrestha, B.2    Marri, A.3    Mahan, D.4    Engle, M.5
  • 21
    • 0031020410 scopus 로고    scopus 로고
    • The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: Potential implications in haemorrhagic fever pathogenesis
    • Falconar, A. K. 1997. The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis. Arch. Virol. 142:897-916.
    • (1997) Arch. Virol. , vol.142 , pp. 897-916
    • Falconar, A.K.1
  • 22
    • 0025102185 scopus 로고
    • Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis
    • Falgout, B., M. Bray, J. J. Schlesinger, and C. J. Lai. 1990. Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis. J. Virol. 64:4356-4363.
    • (1990) J. Virol. , vol.64 , pp. 4356-4363
    • Falgout, B.1    Bray, M.2    Schlesinger, J.J.3    Lai, C.J.4
  • 23
    • 0024553952 scopus 로고
    • Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a
    • Falgout, B., R. Chanock, and C. J. Lai. 1989. Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a. J. Virol. 63:1852-1860.
    • (1989) J. Virol. , vol.63 , pp. 1852-1860
    • Falgout, B.1    Chanock, R.2    Lai, C.J.3
  • 24
    • 0025350163 scopus 로고
    • Membrane association and secretion of the Japanese encephalitis virus NS1 protein from cells expressing NS1 cDNA
    • Fan, W. F., and P. W. Mason. 1990. Membrane association and secretion of the Japanese encephalitis virus NS1 protein from cells expressing NS1 cDNA. Virology 177:470-476.
    • (1990) Virology , vol.177 , pp. 470-476
    • Fan, W.F.1    Mason, P.W.2
  • 25
    • 62749140776 scopus 로고    scopus 로고
    • A conserved predicted pseudoknot in the NS2A-encoding sequence of West Nile and Japanese encephalitis flaviviruses suggests NS1′ may derive from ribosomal frameshifting
    • Firth, A. E., and J. F. Atkins. 2009. A conserved predicted pseudoknot in the NS2A-encoding sequence of West Nile and Japanese encephalitis flaviviruses suggests NS1′ may derive from ribosomal frameshifting. Virol. J. 6:14.
    • (2009) Virol. J. , vol.6 , pp. 14
    • Firth, A.E.1    Atkins, J.F.2
  • 26
    • 0032994359 scopus 로고    scopus 로고
    • Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion
    • Flamand, M., F. Megret, M. Mathieu, J. Lepault, F. A. Rey, and V. Deubel. 1999. Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion. J. Virol. 73:6104-6110.
    • (1999) J. Virol. , vol.73 , pp. 6104-6110
    • Flamand, M.1    Megret, F.2    Mathieu, M.3    Lepault, J.4    Rey, F.A.5    Deubel, V.6
  • 27
    • 0022586234 scopus 로고
    • Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice
    • Gould, E. A., A. Buckley, A. D. Barrett, and N. Cammack. 1986. Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice. J. Gen. Virol. 67:591-595.
    • (1986) J. Gen. Virol. , vol.67 , pp. 591-595
    • Gould, E.A.1    Buckley, A.2    Barrett, A.D.3    Cammack, N.4
  • 28
    • 0014772630 scopus 로고
    • Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion
    • Halstead, S. B. 1970. Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion. Yale J. Biol. Med. 42:350-362.
    • (1970) Yale J. Biol. Med. , vol.42 , pp. 350-362
    • Halstead, S.B.1
  • 29
    • 0023784098 scopus 로고
    • Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus
    • Henchal, E. A., L. S. Henchal, and J. J. Schlesinger. 1988. Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus. J. Gen. Virol. 69:2101-2107.
    • (1988) J. Gen. Virol. , vol.69 , pp. 2101-2107
    • Henchal, E.A.1    Henchal, L.S.2    Schlesinger, J.J.3
  • 30
    • 0033870602 scopus 로고    scopus 로고
    • Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction
    • Jacobs, M. G., P. J. Robinson, C. Bletchly, J. M. Mackenzie, and P. R. Young. 2000. Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction. FASEB J. 14:1603-1610.
    • (2000) FASEB J. , vol.14 , pp. 1603-1610
    • Jacobs, M.G.1    Robinson, P.J.2    Bletchly, C.3    Mackenzie, J.M.4    Young, P.R.5
  • 31
    • 0026585147 scopus 로고
    • High-level expression of the tick-borne encephalitis virus NS1 protein by using an adenovirus-based vector: Protection elicited in a murine model
    • Jacobs, S. C., J. R. Stephenson, and G. W. Wilkinson. 1992. High-level expression of the tick-borne encephalitis virus NS1 protein by using an adenovirus-based vector: protection elicited in a murine model. J. Virol. 66:2086-2095.
    • (1992) J. Virol. , vol.66 , pp. 2086-2095
    • Jacobs, S.C.1    Stephenson, J.R.2    Wilkinson, G.W.3
  • 32
    • 0028141667 scopus 로고
    • Protection elicited by a replication-defective adenovirus vector expressing the tickborne encephalitis virus non-structural glycoprotein NS1
    • Jacobs, S. C., J. R. Stephenson, and G. W. Wilkinson. 1994. Protection elicited by a replication-defective adenovirus vector expressing the tickborne encephalitis virus non-structural glycoprotein NS1. J. Gen. Virol. 75:2399-2402.
    • (1994) J. Gen. Virol. , vol.75 , pp. 2399-2402
    • Jacobs, S.C.1    Stephenson, J.R.2    Wilkinson, G.W.3
  • 33
    • 0034011620 scopus 로고    scopus 로고
    • cis- and trans-Acting elements in flavivirus RNA replication
    • Khromykh, A. A., P. L. Sedlak, and E. G. Westaway. 2000. cis- and trans-Acting elements in flavivirus RNA replication. J. Virol. 74:3253-3263.
    • (2000) J. Virol. , vol.74 , pp. 3253-3263
    • Khromykh, A.A.1    Sedlak, P.L.2    Westaway, E.G.3
  • 34
    • 0032829767 scopus 로고    scopus 로고
    • trans-Complementation analysis of the flavivirus Kunjin ns5 gene reveals an essential role for translation of its N-terminal half in RNA replication
    • Khromykh, A. A., P. L. Sedlak, and E. G. Westaway. 1999. trans-Complementation analysis of the flavivirus Kunjin ns5 gene reveals an essential role for translation of its N-terminal half in RNA replication. J. Virol. 73:9247-9255.
    • (1999) J. Virol. , vol.73 , pp. 9247-9255
    • Khromykh, A.A.1    Sedlak, P.L.2    Westaway, E.G.3
  • 35
    • 0030996972 scopus 로고    scopus 로고
    • Construction of infectious cDNA clones for dengue 2 virus: Strain 16681 and its attenuated vaccine derivative, strain PDK-53
    • Kinney, R. M., S. Butrapet, G. J. Chang, K. R. Tsuchiya, J. T. Roehrig, N. Bhamarapravati, and D. J. Gubler. 1997. Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53. Virology 230:300-308.
    • (1997) Virology , vol.230 , pp. 300-308
    • Kinney, R.M.1    Butrapet, S.2    Chang, G.J.3    Tsuchiya, K.R.4    Roehrig, J.T.5    Bhamarapravati, N.6    Gubler, D.J.7
  • 36
    • 65349159136 scopus 로고    scopus 로고
    • Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells
    • Krishna, V. D., M. Rangappa, and V. Satchidanandam. 2009. Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells. J. Virol. 83:4766-4777.
    • (2009) J. Virol. , vol.83 , pp. 4766-4777
    • Krishna, V.D.1    Rangappa, M.2    Satchidanandam, V.3
  • 37
    • 0037108657 scopus 로고    scopus 로고
    • High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    • Libraty, D. H., P. R. Young, D. Pickering, T. P. Endy, S. Kalayanarooj, S. Green, D. W. Vaughn, A. Nisalak, F. A. Ennis, and A. L. Rothman. 2002. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J. Infect. Dis. 186:1165-1168.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1165-1168
    • Libraty, D.H.1    Young, P.R.2    Pickering, D.3    Endy, T.P.4    Kalayanarooj, S.5    Green, S.6    Vaughn, D.W.7    Nisalak, A.8    Ennis, F.A.9    Rothman, A.L.10
  • 38
  • 39
    • 0000163169 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), 4th ed. Lippincott Williams & Wilkins, Philadelphia, PA
    • Lindenbach, B. D., and C. M. Rice. 2001. Flaviviridae: the viruses and their replication, p. 991-1041. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), Fields virology, vol. 1, 4th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
    • (2001) Fields Virology , vol.1 , pp. 991-1041
    • Lindenbach, B.D.1    Rice, C.M.2
  • 40
    • 0033034992 scopus 로고    scopus 로고
    • Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function
    • Lindenbach, B. D., and C. M. Rice. 1999. Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function. J. Virol. 73:4611-4621.
    • (1999) J. Virol. , vol.73 , pp. 4611-4621
    • Lindenbach, B.D.1    Rice, C.M.2
  • 41
    • 0030774240 scopus 로고    scopus 로고
    • trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication
    • Lindenbach, B. D., and C. M. Rice. 1997. trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication. J. Virol. 71:9608-9617.
    • (1997) J. Virol. , vol.71 , pp. 9608-9617
    • Lindenbach, B.D.1    Rice, C.M.2
  • 42
    • 44049104986 scopus 로고    scopus 로고
    • Use of a commercial enzyme immunoassay to monitor dengue virus replication in cultured cells
    • Ludert, J. E., C. Mosso, I. Ceballos-Olvera, and R. M. del Angel. 2008. Use of a commercial enzyme immunoassay to monitor dengue virus replication in cultured cells. Virol. J. 5:51.
    • (2008) Virol. J. , vol.5 , pp. 51
    • Ludert, J.E.1    Mosso, C.2    Ceballos-Olvera, I.3    Del Angel, R.M.4
  • 44
    • 0029941322 scopus 로고    scopus 로고
    • Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication
    • Mackenzie, J. M., M. K. Jones, and P. R. Young. 1996. Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology 220:232-240.
    • (1996) Virology , vol.220 , pp. 232-240
    • Mackenzie, J.M.1    Jones, M.K.2    Young, P.R.3
  • 45
    • 10944252079 scopus 로고    scopus 로고
    • Emerging flaviviruses: The spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    • Mackenzie, J. S., D. J. Gubler, and L. R. Petersen. 2004. Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat. Med. 10:S98-109.
    • (2004) Nat. Med. , vol.10
    • Mackenzie, J.S.1    Gubler, D.J.2    Petersen, L.R.3
  • 46
    • 0024502091 scopus 로고
    • Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells
    • Mason, P. W. 1989. Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells. Virology 169:354-364.
    • (1989) Virology , vol.169 , pp. 354-364
    • Mason, P.W.1
  • 48
    • 0030218225 scopus 로고    scopus 로고
    • Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: Effects on virus replication and mouse neurovirulence
    • Muylaert, I. R., T. J. Chambers, R. Galler, and C. M. Rice. 1996. Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: effects on virus replication and mouse neurovirulence. Virology 222:159-168.
    • (1996) Virology , vol.222 , pp. 159-168
    • Muylaert, I.R.1    Chambers, T.J.2    Galler, R.3    Rice, C.M.4
  • 52
    • 0028345969 scopus 로고
    • Glycosylation mutants of dengue virus NS1 protein
    • Pryor, M. J., and P. J. Wright. 1994. Glycosylation mutants of dengue virus NS1 protein. J. Gen. Virol. 75:1183-1187.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1183-1187
    • Pryor, M.J.1    Wright, P.J.2
  • 53
    • 0028810904 scopus 로고
    • Double-subgenomic Sindbis virus recombinants expressing immunogenic proteins of Japanese encephalitis virus induce significant protection in mice against lethal JEV infection
    • Pugachev, K. V., P. W. Mason, R. E. Shope, and T. K. Frey. 1995. Double-subgenomic Sindbis virus recombinants expressing immunogenic proteins of Japanese encephalitis virus induce significant protection in mice against lethal JEV infection. Virology 212:587-594.
    • (1995) Virology , vol.212 , pp. 587-594
    • Pugachev, K.V.1    Mason, P.W.2    Shope, R.E.3    Frey, T.K.4
  • 54
    • 84925561440 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted.
  • 55
    • 33947365512 scopus 로고    scopus 로고
    • Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses
    • Ryman, K. D., C. L. Gardner, C. W. Burke, K. C. Meier, J. M. Thompson, and W. B. Klimstra. 2007. Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses. J. Virol. 81:3563-3573.
    • (2007) J. Virol. , vol.81 , pp. 3563-3573
    • Ryman, K.D.1    Gardner, C.L.2    Burke, C.W.3    Meier, K.C.4    Thompson, J.M.5    Klimstra, W.B.6
  • 56
    • 0023030604 scopus 로고
    • Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1
    • Schlesinger, J. J., M. W. Brandriss, C. B. Cropp, and T. P. Monath. 1986. Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1. J. Virol. 60:1153-1155.
    • (1986) J. Virol. , vol.60 , pp. 1153-1155
    • Schlesinger, J.J.1    Brandriss, M.W.2    Cropp, C.B.3    Monath, T.P.4
  • 57
    • 0022361494 scopus 로고
    • Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48
    • Schlesinger, J. J., M. W. Brandriss, and E. E. Walsh. 1985. Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48. J. Immunol. 135:2805-2809.
    • (1985) J. Immunol. , vol.135 , pp. 2805-2809
    • Schlesinger, J.J.1    Brandriss, M.W.2    Walsh, E.E.3
  • 58
    • 0027180431 scopus 로고
    • The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice
    • DOI 10.1006/viro.1993.1015
    • Schlesinger, J. J., M. Foltzer, and S. Chapman. 1993. The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice. Virology 192:132-141. (Pubitemid 23213234)
    • (1993) Virology , vol.192 , Issue.1 , pp. 132-141
    • Schlesinger, J.J.1    Foltzer, M.2    Chapman, S.3
  • 60
    • 0030846512 scopus 로고    scopus 로고
    • Ultrastructure of Kunjin virus-infected cells: Colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures
    • Westaway, E. G., J. M. Mackenzie, M. T. Kenney, M. K. Jones, and A. A. Khromykh. 1997. Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures. J. Virol. 71:6650-6661.
    • (1997) J. Virol. , vol.71 , pp. 6650-6661
    • Westaway, E.G.1    Mackenzie, J.M.2    Kenney, M.T.3    Jones, M.K.4    Khromykh, A.A.5
  • 63
    • 50149084681 scopus 로고    scopus 로고
    • West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction
    • Wilson, J. R., P. F. de Sessions, M. A. Leon, and F. Scholle. 2008. West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction. J. Virol. 82:8262-8271.
    • (2008) J. Virol. , vol.82 , pp. 8262-8271
    • Wilson, J.R.1    De Sessions, P.F.2    Leon, M.A.3    Scholle, F.4
  • 64
    • 0024345888 scopus 로고
    • Newly synthesized dengue-2 virus nonstructural protein NS1 is a soluble protein but becomes partially hydrophobic and membrane-associated after dimerization
    • Winkler, G., S. E. Maxwell, C. Ruemmler, and V. Stollar. 1989. Newly synthesized dengue-2 virus nonstructural protein NS1 is a soluble protein but becomes partially hydrophobic and membrane-associated after dimerization. Virology 171:302-305.
    • (1989) Virology , vol.171 , pp. 302-305
    • Winkler, G.1    Maxwell, S.E.2    Ruemmler, C.3    Stollar, V.4
  • 65
    • 0023857108 scopus 로고
    • Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer
    • Winkler, G., V. B. Randolph, G. R. Cleaves, T. E. Ryan, and V. Stollar. 1988. Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer. Virology 162:187-196.
    • (1988) Virology , vol.162 , pp. 187-196
    • Winkler, G.1    Randolph, V.B.2    Cleaves, G.R.3    Ryan, T.E.4    Stollar, V.5
  • 66
    • 0036196402 scopus 로고    scopus 로고
    • Antiviral effects of an iminosugar derivative on flavivirus infections
    • Wu, S. F., C. J. Lee, C. L. Liao, R. A. Dwek, N. Zitzmann, and Y. L. Lin. 2002. Antiviral effects of an iminosugar derivative on flavivirus infections. J. Virol. 76:3596-3604.
    • (2002) J. Virol. , vol.76 , pp. 3596-3604
    • Wu, S.F.1    Lee, C.J.2    Liao, C.L.3    Dwek, R.A.4    Zitzmann, N.5    Lin, Y.L.6
  • 67
    • 0036838992 scopus 로고    scopus 로고
    • Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59
    • Yount, B., M. R. Denison, S. R. Weiss, and R. S. Baric. 2002. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J. Virol. 76:11065-11078.
    • (2002) J. Virol. , vol.76 , pp. 11065-11078
    • Yount, B.1    Denison, M.R.2    Weiss, S.R.3    Baric, R.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.