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S Appenzeller AE Clarke P Panopalis, et al. 2009 The relationship between renal activity and quality of life in systemic lupus erythematosus J Rheumatol 36 947 952 10.3899/jrheum.080822 19369453 SLE patients with active renal disease had a slightly poorer QoL (physical subscales) than those without renal disease; however, it was not possible to accurately estimate whether a longitudinal change in renal disease activity was associated with a change in QoL.
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10.1080/03009740802415527 1:STN:280:DC%2BD1M7psVynuw%3D%3D 18991189 This study evaluated and demonstrated the effects of persistent active disease and previous and new damage on the deterioration of SF-36 scores
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CC Mok LY Ho MY Cheung, et al. 2009 Effect of disease activity and damage on quality of life in patients with systemic lupus erythematosus: a 2-year prospective study Scand J Rheumatol 38 121 127 10.1080/03009740802415527 1:STN:280:DC%2BD1M7psVynuw%3D%3D 18991189 This study evaluated and demonstrated the effects of persistent active disease and previous and new damage on the deterioration of SF-36 scores
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This was a comparative study of demographic and HRQoL variables in two African American SLE patient groups of different genetic admixtures and geographic locations (urban and rural). Significantly worse HRQoL was found among the urban African Americans than among their rural counterparts
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A Dua DL Kamen AL Barnado, et al. 2009 Variable health-related quality of life among African American cohorts of patients with systemic lupus erythematosus Arthritis Rheum 60 10S S112 This was a comparative study of demographic and HRQoL variables in two African American SLE patient groups of different genetic admixtures and geographic locations (urban and rural). Significantly worse HRQoL was found among the urban African Americans than among their rural counterparts
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1:STN:280:DC%2BD1M3ktV2jsg%3D%3D 19327231 The SF-6D utility measure was used in this multiethnic study. Hispanic-Texan ethnicity and higher levels of social support were found to be positive predictors of HRQoL, whereas sociodemographic (older age, poverty) and disease-related (greater disease activity and damage, higher levels of fatigue, helplessness, and abnormal illness-related behaviors) variables were found to be negative predictors; prior SF-6D was found to be the strongest predictor of subsequent HRQoL
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ML Sanchez G McGwin Jr S Durán, et al. 2009 Factors predictive of overall health over the course of the disease in patients with systemic lupus erythematosus from the LUMINA cohort (LXII): use of the SF-6D Clin Exp Rheumatol 27 67 71 1:STN:280:DC%2BD1M3ktV2jsg%3D%3D 19327231 The SF-6D utility measure was used in this multiethnic study. Hispanic-Texan ethnicity and higher levels of social support were found to be positive predictors of HRQoL, whereas sociodemographic (older age, poverty) and disease-related (greater disease activity and damage, higher levels of fatigue, helplessness, and abnormal illness-related behaviors) variables were found to be negative predictors; prior SF-6D was found to be the strongest predictor of subsequent HRQoL
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10.1002/art.22908 17665468 In this multiethnic SLE cohort, the SF-6D was found to be associated with damage accrual, but not with mortality
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M Fernández GS Alarcón G McGwin Jr, et al. 2007 Using the Short Form 6D, as an overall measure of health, to predict damage accrual and mortality in patients with systemic lupus erythematosus: XLVII, results from a multiethnic US cohort Arthritis Rheum 57 986 992 10.1002/art.22908 17665468 In this multiethnic SLE cohort, the SF-6D was found to be associated with damage accrual, but not with mortality
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10.3899/jrheum.090778 20032098 This was a large comparison study of the EQ-5D and SF-36 (1316 SLE patients vs 13,722 rheumatoid arthritis, 3623 with noninflammatory rheumatic disorders, and 2733 with fibromyalgia). No differences in the EQ-5D and PCS scores among patients with these diseases were found. The MCS of the SF-36 was found to be lower in SLE than in rheumatoid arthritis and noninflammatory rheumatic disorders; poor QoL in SLE was predicted by disease damage and the number of comorbid events
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F Wolfe K Michaud T Li RS Katz 2010 EQ-5D and SF-36 quality of life measures in systemic lupus erythematosus: comparisons with rheumatoid arthritis, noninflammatory rheumatic disorders, and fibromyalgia J Rheumatol 37 296 304 10.3899/jrheum.090778 20032098 This was a large comparison study of the EQ-5D and SF-36 (1316 SLE patients vs 13,722 rheumatoid arthritis, 3623 with noninflammatory rheumatic disorders, and 2733 with fibromyalgia). No differences in the EQ-5D and PCS scores among patients with these diseases were found. The MCS of the SF-36 was found to be lower in SLE than in rheumatoid arthritis and noninflammatory rheumatic disorders; poor QoL in SLE was predicted by disease damage and the number of comorbid events
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1:CAS:528:DC%2BD2sXhtVSkt7bK 17659757 This small study compared the treatment effect of cyclophosphamide pulses plus oral prednisone versus azathioprine combined with intravenous methylprednisolone during a 24-month period on HRQoL in 87 predominantly Caucasian patients with proliferative LN. The study showed that aggressive treatment with immunosuppressive drugs and concomitant glucocorticoids improves HRQoL, especially in the first year
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C Grootscholten FJ Snoek M Bijl, et al. 2007 Health-related quality of life and treatment burden in patients with proliferative lupus nephritis treated with cyclophosphamide or azathioprine/methylprednisolone in a randomized controlled trial J Rheumatol 34 1699 1707 1:CAS:528:DC%2BD2sXhtVSkt7bK 17659757 This small study compared the treatment effect of cyclophosphamide pulses plus oral prednisone versus azathioprine combined with intravenous methylprednisolone during a 24-month period on HRQoL in 87 predominantly Caucasian patients with proliferative LN. The study showed that aggressive treatment with immunosuppressive drugs and concomitant glucocorticoids improves HRQoL, especially in the first year
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KB Dussán L Magder RA Brodsky, et al. 2008 High dose cyclophosphamide performs better than monthly dose cyclophosphamide in quality of life measures Lupus 17 1079 1085 10.1177/0961203308093828 19029275 In this small randomized controlled trial, high-dose cyclophosphamide was compared with monthly intravenous cyclophosphamide in first-time cyclophosphamide users. Improvement in several components of the SF-36 was demonstrated at 6 months in the high-dose cyclophosphamide patient group, but equal improvement in the two arms was demonstrated at 36 months
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SS Uppal SJ Hayat R Raghupathy 2009 Efficacy and safety of infliximab in active SLE: a pilot study Lupus 18 690 697 10.1177/0961203309102557 1:CAS:528:DC%2BD1MXptVOjtb4%3D 19502264
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The beneficial effects of hydroxychloroquine in preventing major lupus flares, retarding damage accrual, and improving patient survival are well-known; however, no demonstrable effect of hydroxychloroquine on the LupusQoL-US or the LupusPRO could be demonstrated in this study
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M Jolly D Sandler W Sequeira, et al. 2009 Hydroxy-chloroquine use and disease specific health related quality of life in systemic lupus erythematosus Arthritis Rheum 60 10S S108 The beneficial effects of hydroxychloroquine in preventing major lupus flares, retarding damage accrual, and improving patient survival are well-known; however, no demonstrable effect of hydroxychloroquine on the LupusQoL-US or the LupusPRO could be demonstrated in this study
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