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1
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0032572211
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Vascular complications associated with use of HIV protease inhibitors
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Gallet B, Pulik M, Genet P, et al.: Vascular complications associated with use of HIV protease inhibitors. Lancet 1998, 351:1958-1959.
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(1998)
Lancet
, vol.351
, pp. 1958-1959
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Gallet, B.1
Pulik, M.2
Genet, P.3
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2
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17144463863
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Severe premature coronary artery disease with protease inhibitors
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Henry K, Melroe H, Huebsch J, et al.: Severe premature coronary artery disease with protease inhibitors. Lancet 1998, 351:1328.
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(1998)
Lancet
, vol.351
, pp. 1328
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Henry, K.1
Melroe, H.2
Huebsch, J.3
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3
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1642403331
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Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men
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Mary-Krause M, Cotte L, Simon A, et al.: Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men. AIDS 2003, 17:2479-2486
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(2003)
AIDS
, vol.17
, pp. 2479-2486
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Mary-Krause, M.1
Cotte, L.2
Simon, A.3
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4
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34247537169
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Class of antiretroviral drugs and the risk of myocardial infarction
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This is the first study to report association of PI class exposure and NNRTI class exposure with the risk of MI.This cohort study is specifically designed to study the potential effect of antiretroviral drugs on the risk of MI in HIV-infected patients
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DAD Study Group, Friis-Møller N, Reiss P, et al.: Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007, 356:1723-1735. This is the first study to report association of PI class exposure and NNRTI class exposure with the risk of MI.This cohort study is specifically designed to study the potential effect of antiretroviral drugs on the risk of MI in HIV-infected patients.
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(2007)
N Engl J Med
, vol.356
, pp. 1723-1735
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Friis-Møller, N.1
Reiss, P.2
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5
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42649130015
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Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: A multi-cohort collaboration
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This is the first study to report associations of individual NRTI drug exposure and the risk of MI. This cohort study is specifically designed to study the potential effect of antiretroviral drugs on the risk of MI in HIV-infected patients. An association between recent abacavir exposure and the risk of MI was reported
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D:A:D Study Group, Sabin CA, Worm SW, et al.: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 2008, 371:1417-1426. This is the first study to report associations of individual NRTI drug exposure and the risk of MI. This cohort study is specifically designed to study the potential effect of antiretroviral drugs on the risk of MI in HIV-infected patients. An association between recent abacavir exposure and the risk of MI was reported.
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(2008)
Lancet
, Issue.371
, pp. 1417-1426
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Sabin, C.A.1
Worm, S.W.2
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6
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75649093029
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Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
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This is a further analysis of the previous study reporting for the first time the associations of exposure to each individual antiretroviral drug with the risk of MI
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Worm W, Sabin C,Weber R, et al.: Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: The Data Collection on Adverse Events ofAnti-HIV Drugs (D:A:D) study. J Infect Dis 2010, 201:318-330. This is a further analysis of the previous study reporting for the first time the associations of exposure to each individual antiretroviral drug with the risk of MI.
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(2010)
J Infect Dis
, vol.201
, pp. 318-330
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Worm, W.1
Sabin, C.2
Weber, R.3
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7
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77955980891
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Abacavir use and risk of acute myocardial infarction and cerebrovascular disease in the HAART era [MOAB202]
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Presented at. Cape Town, South Africa. This study raised the question of whether kidney function may be a confounder when evaluating the association between abacavir exposure and the risk of MI, without bringing definite evidence
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Bedimo R, Westfall A, Drechsler, et al.: Abacavir use and risk of acute myocardial infarction and cerebrovascular disease in the HAART era [MOAB202]. Presented at the 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. Cape Town, South Africa; 2009. This study raised the question of whether kidney function may be a confounder when evaluating the association between abacavir exposure and the risk of MI, without bringing definite evidence.
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(2009)
The 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention
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B.R. Westfall1
A. Drechsler2
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8
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73549088748
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Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: A population-based nationwide cohort study
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Obel N, Farkas DK, Kronborg G, et al.: Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study.HIV Med 2010, 11:130-136.
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(2010)
HIV Med
, vol.11
, pp. 130-136
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Obel, N.1
Farkas, D.K.2
Kronborg, G.3
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9
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77951818147
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Impact of individual drugs on the risk of myocardial infarction in HIV-infected patients: A case-control study nested within the FHDH ANRS Cohort CO4
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press. This is a casecontrol study nested with the FHDH ANRS CO4 cohort for which the analysis plan was specifically written to confirm or refute the association observed between exposure to abacavir and the risk of MI. No association was found with cumulative exposure to abacavir. An association was observed with initiating abacavir, which was not robust in sensitivity analyses, contrary to the other associations found in this study
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Lang S, Mary-Krause M, Cotte L, et al.: Impact of individual drugs on the risk of myocardial infarction in HIV-infected patients: a case-control study nested within the FHDH ANRS Cohort CO4. Arch Intern Med 2010, In press. This is a casecontrol study nested with the FHDH ANRS CO4 cohort for which the analysis plan was specifically written to confirm or refute the association observed between exposure to abacavir and the risk of MI. No association was found with cumulative exposure to abacavir. An association was observed with initiating abacavir, which was not robust in sensitivity analyses, contrary to the other associations found in this study.
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(2010)
Arch Intern Med
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Lang, S.1
Mary-Krause, M.2
Cotte, L.3
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10
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77950645341
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Relation between use of nucleoside reverse transcriptase inhibitors and risk of acute myocardial infarction: A nested case control study using Quebec's public health insurance database [TUPEB175]
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Presented at. Cape Town South Africa
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Durand M, Sheehy O, Baril JH, et al.: Relation between use of nucleoside reverse transcriptase inhibitors and risk of acute myocardial infarction: a nested case control study using Quebec's public health insurance database [TUPEB175]. Presented at the 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. Cape Town, South Africa; 2009.
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(2009)
The 5th IAS Conference on HIV Pathogenesis Treatment and Prevention
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Durand, M.1
Sheehy, O.2
Baril, J.H.3
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11
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67649120904
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No association of abacavir use with risk of myocardial infarction or severe cardiovascular disease events: Results from ACTG A5001 [abstract 721]
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Presented at. Montreal, Canada
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Benson CA, Ribaudo H, Zheng E, et al.: No association of abacavir use with risk of myocardial infarction or severe cardiovascular disease events: results from ACTG A5001 [abstract 721]. Presented at the 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada; 2009.
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(2009)
The 16th Conference on Retroviruses and Opportunistic Infections
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Benson, C.A.1
Ribaudo, H.2
Zheng, E.3
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12
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60649109560
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Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients
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The SMART/INSIGHT and D:A:D Study Groups
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The SMART/INSIGHT and D:A:D Study Groups: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. AIDS 2008, 22:F17-F24.
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(2008)
AIDS
, vol.22
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13
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67651167085
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Risk of myocardial infarction and abacavir therapy: No increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects
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Brothers CH, Hernandez JE, Cutrell AG, et al.: Risk of myocardial infarction and abacavir therapy: No increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects. J Acquir Immune Defic Syndr 2009, 51:20-28.
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(2009)
J Acquir Immune Defic Syndr
, vol.51
, pp. 20-28
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Ch, B.1
Hernandez, J.E.2
Cutrell, A.G.3
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14
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72849149643
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Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-lamivudine: A randomized, 96-week trial
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Martin A, Bloch M, Amin J, et al.: Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-lamivudine: a randomized, 96-week trial. Clin Infect Dis 2009, 49:1591-1601.
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(2009)
Clin Infect Dis
, vol.49
, pp. 1591-1601
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Martin, A.1
Bloch, M.2
Amin, J.3
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15
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68649086238
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Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment
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Smith KY, Patel P, Fine D, et al.: Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS 2009, 23:1547-1556.
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(2009)
AIDS
, vol.23
, pp. 1547-1556
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Smith, K.Y.1
Patel, P.2
Fine, D.3
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16
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34248374863
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Observation versus intervention in the evaluation of drugs: The story of hormone replacement therapy
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Costagliola D: Observation versus intervention in the evaluation of drugs: the story of hormone replacement therapy. C R Biol 2007, 330:347-355.
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(2007)
C R Biol
, vol.330
, pp. 347-355
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Costagliola, D.1
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17
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35649019787
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STROBE Initiative: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration
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This is a very important article to understand the various tenets of designing and reporting and interpreting observational studies
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Vandenbroucke JP, von Elm E, Altman DG, et al.; STROBE Initiative: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med 2007, 4:e297. This is a very important article to understand the various tenets of designing and reporting and interpreting observational studies.
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(2007)
PLoS Med
, vol.4
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Vandenbroucke, J.P.1
Von Elm, E.2
Altman, D.G.3
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18
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0142157169
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Evaluating medication effects outside of clinical trials: New-user designs
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Ray WA: Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol 2003, 158:915-920.
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(2003)
Am J Epidemiol
, vol.158
, pp. 915-920
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Ray, W.A.1
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19
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66949157076
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Association between modifiable and non-modifiable risk factors and specific causes of death in the HAART era: The Data Collection on Adverse Events of Anti-HIV Drugs Study [abstract 145]
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D:A:D Study Group, Presented at the. Montreal, Canada; February
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D:A:D Study Group, Smith C: Association between modifiable and non-modifiable risk factors and specific causes of death in the HAART era: The Data Collection on Adverse Events of Anti-HIV Drugs Study [abstract 145]. Presented at the 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada; February 8-11, 2009.
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(2009)
16th Conference on Retroviruses and Opportunistic Infections
, pp. 8-11
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Smith, C.1
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20
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50649089419
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Abacavir and increased risk of myocardial infarction, reply
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Sabin CA,Worm S, Phillips AN, Lundgren JD: Abacavir and increased risk of myocardial infarction, reply. Lancet 2008, 372:804-805.
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(2008)
Lancet
, vol.372
, pp. 804-805
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Sabin Caworm, S.1
Phillips, A.N.2
Lundgren, J.D.3
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21
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70349769521
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Association of abacavir and impaired endothelial function in treated and suppressed HIVinfected patients
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Hsue PY, Hunt PW, Wu Y, et al.: Association of abacavir and impaired endothelial function in treated and suppressed HIVinfected patients. AIDS 2009, 23:2021-2027.
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(2009)
AIDS
, vol.23
, pp. 2021-2027
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Hsue, P.Y.1
Hunt, P.W.2
Wu, Y.3
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22
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71049184974
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Platelet hyperreactivity in HIV-1-infected patients on abacavir-containing ART [abstract 151LB]
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Presented at the. Montreal Canada; February
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Satchell C, O'Connor E, Peace A, et al.: Platelet hyperreactivity in HIV-1-infected patients on abacavir-containing ART [abstract 151LB]. Presented at the 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada; February 8-11, 2009.
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(2009)
16th Conference on Retroviruses and Opportunistic Infections
, pp. 8-11
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Satchell, C.1
O'connor, E.2
Peace, A.3
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23
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75649110409
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BICOMBO Study Team: Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction
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This is a randomized study analysis to explore various mechanisms (markers of coagulation, inflammation, and endothelial function) that were suggested to explain a potential association between abacavir exposure and the risk of MI, showing no statistical differences
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Martínez E, Larrousse M, Podzamczer D, et al.; BICOMBO Study Team: Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction. AIDS 2010, 24:F1-F9. This is a randomized study analysis to explore various mechanisms (markers of coagulation, inflammation, and endothelial function) that were suggested to explain a potential association between abacavir exposure and the risk of MI, showing no statistical differences.
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(2010)
AIDS
, vol.24
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Martínez, E.1
Larrousse, M.2
Podzamczer, D.3
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24
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84870020344
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STEAL Study Group: Changes in cardiovascular biomarkers with abacavir: A randomized 96-week trial [abstract 718]
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Paper presented at the. San Francisco CA; February
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Humphries A, Amin J, Cooper D, et al.; STEAL Study Group: Changes in cardiovascular biomarkers with abacavir: a randomized, 96-week trial [abstract 718]. Paper presented at the 17th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA; February 16-19, 2010.
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(2010)
th Conference on Retroviruses and Opportunistic Infections
, pp. 16-19
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Humphries, A.1
Amin, J.2
Et Al., C.D.3
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25
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84870007277
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European Medicine Evaluation Agency: Abacavir and the risk of heart attack. Available at. Accessed March
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European Medicine Evaluation Agency: Abacavir and the risk of heart attack. Available at www.ema.europa.eu/pdfs/human/press/pr/24966009en.pdf. Accessed March 2010.
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(2010)
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