-
1
-
-
60349104299
-
The spliceosome: Design principles of a dynamic RNP machine
-
Wahl, M.C., Will, C.L. and Lührmann, R. (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136, 701-718
-
(2009)
Cell
, vol.136
, pp. 701-718
-
-
Wahl, M.C.1
Will, C.L.2
Lührmann, R.3
-
2
-
-
0001877802
-
Splicing of precursors to mRNA by the spliceosome
-
(Gesteland, R.F. and Atkins, J.F., eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor
-
Moore, M.J., Query, C.C. and Sharp, P.A. (1993) Splicing of precursors to mRNA by the spliceosome. In The RNA World (Gesteland, R.F. and Atkins, J.F., eds), pp. 303-357, Cold Spring Harbor Laboratory Press, Cold Spring Harbor
-
(1993)
The RNA World
, pp. 303-357
-
-
Moore, M.J.1
Query, C.C.2
Sharp, P.A.3
-
3
-
-
0032489021
-
Mechanical devices of the spliceosome: Motors, clocks, springs and things
-
Staley, J.P. and Guthrie, C. (1998) Mechanical devices of the spliceosome: motors, clocks, springs and things. Cell 92, 315-326
-
(1998)
Cell
, vol.92
, pp. 315-326
-
-
Staley, J.P.1
Guthrie, C.2
-
4
-
-
0029871680
-
Identification of novel genes required for yeast pre-mrna splicing by means of cold-sensitive mutations
-
Noble, S.M. and Guthrie, C. (1996) Identification of novel genes required for yeast pre-mrna splicing by means of cold-sensitive mutations. Genetics 143, 67-80
-
(1996)
Genetics
, vol.143
, pp. 67-80
-
-
Noble, S.M.1
Guthrie, C.2
-
5
-
-
0029888811
-
An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing
-
Xu, D.M., Nouraini, S., Field, D., Tang, S.J. and Friesen, J.D. (1996) An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing. Nature 381, 709-713
-
(1996)
Nature
, vol.381
, pp. 709-713
-
-
Xu, D.M.1
Nouraini, S.2
Field, D.3
Tang, S.J.4
Friesen, J.D.5
-
6
-
-
0029782402
-
The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases
-
Lauber, J., Fabrizio, P., Teigelkamp, S., Lane, W.S., Hartmann, E. and Lührmann, R. (1996) The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J. 15, 4001-4015
-
(1996)
EMBO J.
, vol.15
, pp. 4001-4015
-
-
Lauber, J.1
Fabrizio, P.2
Teigelkamp, S.3
Lane, W.S.4
Hartmann, E.5
Lührmann, R.6
-
7
-
-
0029854007
-
Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3′ splice site
-
Lin, J. and Rossi, J. (1996) Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3′ splice site. RNA 2, 835-848
-
(1996)
RNA
, vol.2
, pp. 835-848
-
-
Lin, J.1
Rossi, J.2
-
8
-
-
0031741144
-
The human U5-220kD Protein (hPrp8) forms a stable RNA-free complex with several U5-Specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein
-
Achsel, T., Ahrens, K., Brahms, H., Teigelkamp, S. and Lührmann, R. (1998) The human U5-220kD Protein (hPrp8) forms a stable RNA-free complex with several U5-Specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. Mol. Cell. Biol. 18, 6756-6766
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6756-6766
-
-
Achsel, T.1
Ahrens, K.2
Brahms, H.3
Teigelkamp, S.4
Lührmann, R.5
-
9
-
-
0035053295
-
Functional Contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae
-
van Nues, R. and Beggs, J.D. (2001) Functional Contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157, 1457-1467
-
(2001)
Genetics
, vol.157
, pp. 1457-1467
-
-
Van Nues, R.1
Beggs, J.D.2
-
10
-
-
33745613530
-
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
-
Liu, S., Rauhut, R., Vornlocher, H.-P. and Lührmann, R. (2006) The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. RNA 12, 1418-1430
-
(2006)
RNA
, vol.12
, pp. 1418-1430
-
-
Liu, S.1
Rauhut, R.2
Vornlocher, H.-P.3
Lührmann, R.4
-
11
-
-
33847053558
-
Structure of a multipartite protein-protein interaction domain in splicing factor Prp8 and its link to Retinitis pigmentosa
-
Pena, V., Liu, S., Bujnicki, J.M., Lührmann, R. and Wahl, M.C. (2007) Structure of a multipartite protein-protein interaction domain in splicing factor Prp8 and its link to Retinitis pigmentosa. Mol. Cell 25, 615-624
-
(2007)
Mol. Cell
, vol.25
, pp. 615-624
-
-
Pena, V.1
Liu, S.2
Bujnicki, J.M.3
Lührmann, R.4
Wahl, M.C.5
-
12
-
-
67650296697
-
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2
-
Zhang, L., Xu, T., Maeder, C., Bud, L.-O., Shanks, J., Nix, J., Guthrie, C., Pleiss, J.A. and Zhao, R. (2009) Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat. Struct. Mol. Biol. 16, 731-739
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 731-739
-
-
Zhang, L.1
Xu, T.2
Maeder, C.3
Bud, L.-O.4
Shanks, J.5
Nix, J.6
Guthrie, C.7
Pleiss, J.A.8
Zhao, R.9
-
13
-
-
70449625597
-
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome
-
Fabrizio, P., Dannenberg, J., Dube, P., Kastner, B., Stark, H., Urlaub, H. and Lührmann, R. (2009) The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol. Cell 36, 593-608
-
(2009)
Mol. Cell
, vol.36
, pp. 593-608
-
-
Fabrizio, P.1
Dannenberg, J.2
Dube, P.3
Kastner, B.4
Stark, H.5
Urlaub, H.6
Lührmann, R.7
-
14
-
-
0032537739
-
RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2
-
Raghunathan, P.L. and Guthrie, C. (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr. Biol. 8, 847-855
-
(1998)
Curr. Biol.
, vol.8
, pp. 847-855
-
-
Raghunathan, P.L.1
Guthrie, C.2
-
15
-
-
0032515969
-
The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
-
Laggerbauer, B., Achsel, T. and Lührmann, R. (1998) The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. Proc. Natl. Acad. Sci. U.S.A. 95, 4188-4192
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 4188-4192
-
-
Laggerbauer, B.1
Achsel, T.2
Lührmann, R.3
-
16
-
-
33746441457
-
The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase
-
Small, E.C., Leggett, S.R., Winans, A.A. and Staley, J.P. (2006) The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase. Mol. Cell 23, 389-399
-
(2006)
Mol. Cell
, vol.23
, pp. 389-399
-
-
Small, E.C.1
Leggett, S.R.2
Winans, A.A.3
Staley, J.P.4
-
17
-
-
0033047503
-
Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome
-
Kuhn, A.N., Li, Z.R. and Brow, D.A. (1999) Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol. Cell 3, 65-75
-
(1999)
Mol. Cell
, vol.3
, pp. 65-75
-
-
Kuhn, A.N.1
Li, Z.R.2
Brow, D.A.3
-
18
-
-
0033900068
-
Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation
-
Kuhn, A. and Brow, D.A. (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155, 1667-1682
-
(2000)
Genetics
, vol.155
, pp. 1667-1682
-
-
Kuhn, A.1
Brow, D.A.2
-
19
-
-
31044444461
-
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p
-
Bellare, P., Kutach, A.K., Rines, A.K., Guthrie, C. and Sontheimer, E.J. (2006) Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12, 292-302
-
(2006)
RNA
, vol.12
, pp. 292-302
-
-
Bellare, P.1
Kutach, A.K.2
Rines, A.K.3
Guthrie, C.4
Sontheimer, E.J.5
-
20
-
-
43249118936
-
A role for ubiquitin in the spliceosome assembly pathway
-
Bellare, P., Small, E.C., Huang, X., Wohlschlegel, J.A., Staley, J.P. and Sontheimer, E.J. (2008) A role for ubiquitin in the spliceosome assembly pathway. Nat. Struct. Mol. Biol. 15, 444-451
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 444-451
-
-
Bellare, P.1
Small, E.C.2
Huang, X.3
Wohlschlegel, J.A.4
Staley, J.P.5
Sontheimer, E.J.6
-
21
-
-
58149231008
-
ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8
-
Maeder, C., Kutach, A.K. and Guthrie, C. (2008) ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat. Struct. Mol. Biol. 16, 42-48
-
(2008)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 42-48
-
-
Maeder, C.1
Kutach, A.K.2
Guthrie, C.3
-
22
-
-
0030981863
-
Identification of gene encoding a putative RNA-helicase, homologous to SKI2, in chromosome VII of Saccharomyces cerevisiae
-
Martegani, E., Vanoni, M., Mauri, I., Rudoni, S., Saliola, M. and Alberghina, L. (1997) Identification of gene encoding a putative RNA-helicase, homologous to SKI2, in chromosome VII of Saccharomyces cerevisiae. Yeast 13, 391-397
-
(1997)
Yeast
, vol.13
, pp. 391-397
-
-
Martegani, E.1
Vanoni, M.2
Mauri, I.3
Rudoni, S.4
Saliola, M.5
Alberghina, L.6
-
23
-
-
0033056712
-
The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex
-
Kim, H.-D. and Rossi, J. (1999) The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA 5, 959-971
-
(1999)
RNA
, vol.5
, pp. 959-971
-
-
Kim, H.-D.1
Rossi, J.2
-
24
-
-
0034667598
-
Proteins of the endoplasmic-reticulum-associated degradation pathway: Domain detection and function prediction
-
Ponting, C.P. (2000) Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. Biochem. J. 351, 527-535
-
(2000)
Biochem. J.
, vol.351
, pp. 527-535
-
-
Ponting, C.P.1
-
25
-
-
69149090973
-
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase
-
Pena, V., Mozaffari Jovin, S., Fabrizio, P., Orlowski, J., Bujnicki, J.M., Lührmann, R. and Wahl, M.C. (2009) Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Mol. Cell 35, 454-466
-
(2009)
Mol. Cell
, vol.35
, pp. 454-466
-
-
Pena, V.1
Mozaffari Jovin, S.2
Fabrizio, P.3
Orlowski, J.4
Bujnicki, J.M.5
Lührmann, R.6
Wahl, M.C.7
-
26
-
-
34447132375
-
Structural basis for DNA duplex separation by a superfamily-2 helicase
-
Buttner, K., Nehring, S. and Hopfner, K. (2007) Structural basis for DNA duplex separation by a superfamily-2 helicase. Nat. Struct. Mol. Biol. 14, 647-652
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 647-652
-
-
Buttner, K.1
Nehring, S.2
Hopfner, K.3
-
27
-
-
41949094586
-
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains
-
Richards, J., Johnson, K., Liu, H., McRobbie, A., McMahon, S., Oke, M., Carter, L., Naismith, J. and White, M. (2008) Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. J. Biol. Chem. 283, 5118-5126
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 5118-5126
-
-
Richards, J.1
Johnson, K.2
Liu, H.3
McRobbie, A.4
McMahon, S.5
Oke, M.6
Carter, L.7
Naismith, J.8
White, M.9
-
28
-
-
0023782352
-
The spliceosomal RNA U6 is remarkably conserved from yeast to mammals
-
Brow, D.A. and Guthrie, C. (1988) The spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 334, 213-218
-
(1988)
Nature
, vol.334
, pp. 213-218
-
-
Brow, D.A.1
Guthrie, C.2
-
29
-
-
33750947173
-
Retinitis pigmentosa
-
Hartong, D.T., Breson, E.L. and Dryja, T. (2006) Retinitis pigmentosa. Lancet 368, 1795-1809
-
(2006)
Lancet
, vol.368
, pp. 1795-1809
-
-
Hartong, D.T.1
Breson, E.L.2
Dryja, T.3
-
30
-
-
35848950003
-
Prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast
-
Boon, K.-L., Grainger, R.J., Ehsani, P., Barras, D., Auchynnikava, T., Inglehearn, C.F. and Beggs, J.D. (2007) prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast. Nat. Struct. Mol. Biol. 14, 1077-1083
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1077-1083
-
-
Boon, K.-L.1
Grainger, R.J.2
Ehsani, P.3
Barras, D.4
Auchynnikava, T.5
Inglehearn, C.F.6
Beggs, J.D.7
-
31
-
-
71849087061
-
Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs
-
Zhao, C., Bellur, D., Lu, S., Zhao, F., Grassi, M.A., Bowne, S.J., Sullivan, L.S., Daiger, S.P., Chen, L.J., Pang, C.P. et al. (2009) Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. Am. J. Hum. Genet. 85, 617-627
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 617-627
-
-
Zhao, C.1
Bellur, D.2
Lu, S.3
Zhao, F.4
Grassi, M.A.5
Bowne, S.J.6
Sullivan, L.S.7
Daiger, S.P.8
Chen, L.J.9
Pang, C.P.10
-
32
-
-
77449121298
-
Mutations in ASCC3L1 on chromosome 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese Family
-
Li, N., Mei, H., MacDonald, I.M., Jiao, X. and Fielding Hejtmancik, J. (2009) Mutations in ASCC3L1 on chromosome 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese Family. Invest. Ophthalmol. Visual Sci. 51, 1036-1043
-
(2009)
Invest. Ophthalmol. Visual Sci.
, vol.51
, pp. 1036-1043
-
-
Li, N.1
Mei, H.2
MacDonald, I.M.3
Jiao, X.4
Fielding Hejtmancik, J.5
|