The role of the pathologist in rectal cancer diagnosis and staging and surgical quality assessment

Clinical and Translational Oncology

Volumn 12, Issue 5, 2010, Pages 339-345

  Faus, Carmen ^a   Roda, Desamparados ^a   Frasson, Matteo ^b   Roselló, Susana ^a   García Granero, Eduardo ^b   Flor Lorente, Blas ^b   Navarro, Samuel ^a  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Circumferential radial margin; Diagnosis; Pathologic assessment; Rectal cancer

Indexed keywords

CANCER DIAGNOSIS; CANCER INVASION; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER STAGING; DIAGNOSTIC ACCURACY; ECHOGRAPHY; ENDORECTAL ULTRASONOGRAPHY; HISTOPATHOLOGY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; QUALITY CONTROL; RECTOSCOPY; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM ANTERIOR RESECTION; RECTUM CANCER; REVIEW; SURGICAL APPROACH; SURGICAL TECHNIQUE; TUMOR VOLUME;

CARCINOMA; DIGESTIVE SYSTEM SURGICAL PROCEDURES; HUMANS; NEOPLASM STAGING; PATHOLOGY, CLINICAL; PREOPERATIVE CARE; PROFESSIONAL ROLE; PROGNOSIS; QUALITY CONTROL; RECTAL NEOPLASMS;

EID: 77955953409     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-010-0515-7     Document Type: Review

References (62)

1. Heald RJ (1988) The 'Holy Plane' of rectal surgery. J R Soc Med 81:503-508
2. Landheer ML, Therasse P, van de Velde CJ (2002) The importance of quality assurance in surgical oncology. Eur J Surg Oncol 28:571-602
3. Church JM, Gibbs P, Chao MW, Tjandra JJ (2003) Optimizing the outcome for patients with rectal cancer. Dis Colon Rectum 46:389-402
4. Radcliffe A, Brown G (2001) Will MRI provide maps of lines of excision for rectal cancer? Lancet 357:495-496
5. Nelson H, Sargent DJ (2001) Refining multimodal therapy for rectal cancer. N Engl J Med 345:690-692
6. Heald RJ, Ryall RD (1986) Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1:1479-1482
7. Kelly MJ, Lloyd TD, Marshall D et al (2003) A snapshot of MDT working and patient mapping in the UK colorectal cancer centres in 2002. Colorectal Dis 5:577-581
8. Quirke P (1997) Limitations of existing systems of staging for rectal cancer: the forgotten margin. In: Soreide O, Norstein J; eds. Rectal cancer surgery: optimisation, standardisation, documentation. Springer Verlag, Berlin pp. 63-81
9. Williams GT, Shepherd NA on behalf of the RCPath Cancer Services Working Group (2007) Dataset for colorectal cancer (2nd edn). The Royal College of Pathologists. Available at www. rcpath.org
10. Burton S, Brown G, Daniels IR et al (2006) MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer 94:351-357
11. Cervantes A, Rodriguez-Braun E, Navarro S et al (2007) Integrative decisions in rectal cancer. Ann Oncol 18(Suppl 9):ix127-ix131
12. Cervantes A, Rosello S, Rodriguez-Braun E et al (2008) Progress in the multidisciplinary treatment of gastrointestinal cancer and the impact on clinical practice: perioperative management of rectal cancer. Ann Oncol 19(Suppl 7):vii266-vii272
13. Salerno G, Daniels IR, Moran BJ et al (2006) Clarifying margins in the multidisciplinary management of rectal cancer: the MERCURY experience. Clin Radiol 61:916-923
14. Wiggers T (2003) Staging of rectal cancer. Br J Surg 90:895-896
15. MERCURY Study Group (2006) Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 333:779
16. Heald RJ, Moran BJ, Ryall RD et al (1998) Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg 133:894-899
17. Goh V, Halligan S, Bartram CI (2004) Local radiological staging of rectal cancer. Clin Radiol 59:215-226
18. Hall NR, Finan PJ, al-Jaberi T et al (1998) Circumferential margin involvement after mesorectal excision of rectal cancer with curative intent. Predictor of survival but not local recurrence? Dis Colon Rectum 41:979-983
19. Arbman G, Nilsson E, Hallbook O, Sjodahl R (1996) Local recurrence following total mesorectal excision for rectal cancer. Br J Surg 83:375-379
20. Lopez-Kostner F, Lavery IC, Hool GR et al (1998) Total mesorectal excision is not necessary for cancers of the upper rectum. Surgery 124:612-617
21. Heald RJ, Smedh RK, Kald A et al (1997) Abdominoperineal excision of the rectum-an endangered operation. Norman Nigro Lectureship. Dis Colon Rectum 40:747-751
22. Lavery IC, Lopez-Kostner F, Fazio VW et al (1997) Chances of cure are not compromised with sphincter-saving procedures for cancer of the lower third of the rectum. Surgery 122:779-784
23. Nagtegaal ID, van de Velde CJ, Marijnen CA et al (2005) Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol 23:9257-9264
24. den Dulk M, Putter H, Collette L et al (2009) The abdominoperineal resection itself is associated with an adverse outcome: the European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer. Eur J Cancer 45:1175-1183
25. Holm T, Ljung A, Haggmark T (2007) Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer. Br J Surg 94:232-238
26. West NP, Finan PJ, Anderin C (2008) Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer. J Clin Oncol 26:3517-3522
27. Quirke P (2003) Training and quality assurance for rectal cancer: 20 years of data is enough. Lancet Oncol 4:695-702
28. Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2:996-999
29. Nagtegaal ID, van de Velde CJ, van der Worp E (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 20:1729-1734
30. Nagtegaal ID, Marijnen CA, Kranenbarg EK (2002) Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit. Am J Surg Pathol 26:350-357
31. Hermanek P, Hohenberger W, Klimpfinger M (2003) The pathological assessment of mesorectal excision: implications for further treatment and quality management. Int J Colorectal Dis 18:335-341
32. Enker WE, Levi GS (2009) Macroscopic assessment of mesorectal excision. Cancer 115:4890-4894
33. Garcia-Granero E, Faiz O, Munoz E et al (2009) Macroscopic assessment of mesorectal excision in rectal cancer: a useful tool for improving quality control in a multidisciplinary team. Cancer 115:3400-3411
34. Chan KW, Boey J, Wong SK (1985) A method of reporting radial invasion and surgical clearance of rectal carcinoma. Histopathology 9:1319-1327
35. de Haas-Kock DF, Baeten CG, Jager JJ et al (1996) Prognostic significance of radial margins of clearance in rectal cancer. Br J Surg 83:781-785
36. Adam IJ, Mohamdee MO, Martin IG et al (1994) Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 344:707-711
37. Wibe A, Rendedal PR, Svensson E et al (2002) Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg 89:327-334
38. Birbeck KF, Macklin CP, Tiffin NJ et al (2002) Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg 235:449-457
39. Ng IO, Luk IS, Yuen ST et al (1993) Surgical lateral clearance in resected rectal carcinomas. A multivariate analysis of clinicopathologic features. Cancer 71:1972-1976
40. Mekenkamp LJ, van Krieken JH, Marijnen CA et al (2009) Lymph node retrieval in rectal cancer is dependent on many factors-the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol 33(10):1547-1553
41. Cianchi F, Palomba A, Boddi V et al (2002) Lymph node recovery from colorectal tumor specimens: recommendation for a minimum number of lymph nodes to be examined. World J Surg 26:384-389
42. Kim YW, Kim NK, Min BS (2009) The influence of the number of retrieved lymph nodes on staging and survival in patients with stage II and III rectal cancer undergoing tumor-specific mesorectal excision. Ann Surg 249:965-972
43. Kim YW, Kim NK, Min BS et al (2009) The prognostic impact of the number of lymph nodes etrieved after neoadjuvant chemoradiotherapy with mesorectal excision for rectal cancer. J Surg Oncol 100:1-7
44. Kerwel TG, Spatz J, Anthuber M et al (2009) Injecting methylene blue into the inferior mesenteric artery assures an adequate lymph node harvest and eliminates pathologist variability in nodal staging for rectal cancer. Dis Colon Rectum 52:935-941
45. Sobin LH, Fleming ID (1997) TNM classification of malignant tumors, fifth edition. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 80:1803-1804
46. Sobin LH (2003) TNM, sixth edition: new developments in general concepts and rules. Semin Surg Oncol 21:19-22
47. Goldstein NS, Turner JR (2000) Pericolonic tumor deposits in patients with T3N+MO colon adenocarcinomas: markers of reduced disease free survival and intra-abdominal metastases and their implications for TNM classification. Cancer 88:2228-2238
48. Kapiteijn E, Marijnen CA, Nagtegaal ID et al (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638-646
49. Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer 66:49-55
50. Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740
51. Sebag-Montefiore D (2006) Developments in the use of chemoradiotherapy in rectal cancer. Colorectal Dis 8(Suppl)3:14-17
52. Marijnen CA, Nagtegaal ID, Klein Kranenbarg E et al (2001) No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J Clin Oncol 19:1976-1984
53. Nagtegaal ID, Marijnen CA, Kranenbarg EK et al (2002) Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer. J Pathol 197:20-27
54. Wheeler JM, Warren BF, Jones AC, Mortensen NJ (1999) Preoperative radiotherapy for rectal cancer: implications for surgeons, pathologists and radiologists. Br J Surg 86:1108-1120
55. Dworak O, Keilholz L, Hoffmann A (1997) Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12:19-23
56. Quirke P, Morris E (2007) Reporting colorectal cancer. Histopathology 50:103-112
57. Newland RC, Dent OF, Chapuis PH, Bokey L (1995) Survival after curative resection of lymph node negative colorectal carcinoma. A prospective study of 910 patients. Cancer 76:564-571
58. Jass JR, Atkin WS, Cuzick J et al (1986) The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 10:437-459
59. Tsai HL, Chu KS, Huang YH et al (2009) Predictive factors of early relapse in UICC stage I-III colorectal cancer patients after curative resection. J Surg Oncol 100:736-743
60. Georgescu SO, Neacsu CN, Vintila D et al (2007) [Long-term results after surgery for colorectal adenocarcinoma, stage I-III. Problems of prognosis]. Rev Med Chir Soc Med Nat Iasi 111:932-939.
61. Fitzgerald RH Jr (1982) What is the Dukes' system for carcinoma of the rectum? Dis Colon Rectum 25:474-477
62. Hase K, Shatney C, Johnson D et al (1993) Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum 36:627-635