Treatment of paediatric vancomycin intoxication: A case report and review of the literature

NDT Plus

Volumn 3, Issue 3, 2010, Pages 260-264

  Lemaire, Mathieu ^a,b,c   Connolly, Bairbre ^a   Harvey, Elizabeth ^a   Licht, Christoph ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

haemodialysis; nephrotoxicity; paediatrics; vancomycin overdose

Indexed keywords

AMPHOTERICIN B; CEFOTAXIME; FLUCONAZOLE; HEPARIN; VANCOMYCIN;

ARTICLE; BLOOD CLOTTING DISORDER; CASE REPORT; CHILD CARE; DIALYSIS; DRUG BLOOD LEVEL; DRUG OVERDOSE; DRUG WITHDRAWAL; HUMAN; INFANT; MALE; MEDICATION ERROR; MYCOSIS; NEPHROTOXICITY; OSTEOMYELITIS; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 77955949380     PISSN: 17530784     EISSN: 17530792     Source Type: Journal    
DOI: 10.1093/ndtplus/sfq016     Document Type: Article

References (23)

1. Matzke GR, Zhanel GG, Guay DR. Clinical pharmacokinetics of vancomycin. Clin Pharmacokinet 1986; 11: 257-282
2. Matzke GR, McGory RW, Halstenson CE, Keane WF. Pharmacokinetics of vancomycin in patients with various degrees of renal function. Antimicrob Agents Chemother 1984; 25: 433-437
3. Ghaleb MA, Barber N, Franklin BD, Yeung VW, Khaki ZF, Wong IC. Systematic review of medication errors in pediatric patients. Ann Pharmacother 2006; 40: 1766-1776
4. Rybak MJ, Albrecht LM, Boike SC, Chandrasekar PH. Nephrotoxicity of vancomycin, alone and with an aminoglycoside. J Antimicrob Chemother 1990; 25: 679-687
5. Goetz MB, Sayers J. Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination. J Antimicrob Chemother 1993; 32: 325-334
6. Stork CM. Antibiotics, antifungals, and antivirals. In: LR Goldfrank, N Flomenbaum (eds). Goldfranks Toxicologic Emergencies. 8th Edition; New York, USA: McGraw-Hill, 2006; 851
7. Panzarino VM, Feldstein TJ, Kashtan CE. Charcoal hemoperfusion in a child with vancomycin overdose and chronic renal failure. Pediatr Nephrol 1998; 12: 63-64
8. Lindholm DD, Murray JS. Persistence of vancomycin in the blood during renal failure and its treatment by hemodialysis. N Engl J Med 1966; 274: 1047-1051
9. Quale JM, OHalloran JJ, DeVincenzo N, Barth RH. Removal of vancomycin by high-flux hemodialysis membranes. Antimicrob Agents Chemother 1992; 36: 1424-1426
10. Bunchman T et al. Treatment of vancomycin overdose using high-efficiency dialysis membranes. Pediatr Nephrol 1999; 13: 773-774
11. Ulinski T, Deschênes G, Bensman A. Large-pore haemodialysis membranes: an efficient tool for rapid removal of vancomycin after accidental overdose. Nephrol Dial Transplant 2005; 20: 1517-1518
12. Wicklow B, Ogborn M, Gibson I, Blydt-Hansen T. Biopsy-proven acute tubular necrosis in a child attributed to vancomycin intoxication. Pediatr Nephrol 2006; 21: 1194-1196
13. Shah M, Quigley R. Rapid removal of vancomycin by continuous veno-venous hemofiltration. Pediatr Nephrol 2000; 14: 912-915
14. Ahmad R, Raichura N, Kilbane V, Whitfield E. Vancomycin: a reappraisal. Br Med J 1982; 284: 1953-1954
15. Burkhart KK, Metcalf S, Shurnas E et al. Exchange transfusion and multidose activated charcoal following vancomycin overdose. J Toxicol Clin Toxicol 1992; 30: 285-294
16. Kucukguclu S, Tuncok Y, Ozkan H, Guven H, Uguz A, Maltepe F. Multiple-dose activated charcoal in an accidental vancomycin overdose. J Toxicol Clin Toxicol 1996; 34: 83-86
17. Böhler J, Donauer J, Keller F. Pharmacokinetic principles during continuous renal replacement therapy: drugs and dosage. Kidney Int Suppl 1999; 72: S24-S28
18. DeSoi CA, Sahm DF, Umans JG. Vancomycin elimination during high-flux hemodialysis: kinetic model and comparison of four membranes. Am J Kidney Dis 1992; 20: 354-360
19. Pai AB, Pai MP. Vancomycin dosing in high flux hemodialysis: a limited-sampling algorithm. Am J Health Syst Pharm 2004; 61: 1812-1816
20. Welage LS, Mason NA, Hoffman EJ et al. Influence of cellulose triacetate hemodialyzers on vancomycin pharmacokinetics. J Am Soc Nephrol 1995; 6: 1284-1290
21. Pollard TA, Lampasona V, Akkerman S et al. Vancomycin redistribution: dosing recommendations following high-flux hemodialysis. Kidney Int 1994; 45: 232-237
22. Khairulddin N, Bishop L, Lamagni TL, Sharland M, Duckworth G. Emergence of methicillin resistant Staphylococcus aureus (MRSA) bacteraemia among children in England and Wales, 1990-2001. Arch Dis Child 2004; 89: 378-379
23. Ochoa TJ, Mohr J, Wanger A, Murphy JR, Heresi GP. Communityassociated methicillin-resistant Staphylococcus aureus in pediatric patients. Emerg Infect Dis 2005; 11: 966-968