Expression of periodontal interleukin-6 protein is increased across patients with neither periodontal disease nor diabetes, patients with periodontal disease alone and patients with both diseases

Journal of Periodontal Research

Volumn 45, Issue 5, 2010, Pages 688-694

  Ross, J H ^a   Hardy, D C ^a   Schuyler, C A ^b   Slate, E H ^a   Mize, T W ^a   Huang, Y ^b,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Diabetes mellitus; Gene expression; Interleukin 6 (IL 6); Periodontal diseases

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; DIABETES MELLITUS; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMAGE PROCESSING; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; NONPARAMETRIC TEST; PERIODONTAL DISEASE; PERIODONTIUM;

ADULT; AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-6; MALE; MIDDLE AGED; PERIODONTAL DISEASES; PERIODONTIUM; STATISTICS, NONPARAMETRIC;

EID: 77955949371     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01286.x     Document Type: Article

References (29)

1. Irwin CR, Myrillas TT. The role of IL-6 in the pathogenesis of periodontal disease. Oral Dis 1998, 4:43-47.
2. Cole CM, Sundararaj KP, Leite RS. A trend of increase in periodontal interleukin-6 expression across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases. J Periodontal Res 2008, 43:717-722.
3. Takashiba S, Naruishi K, Murayama Y. Perspective of cytokine regulation for periodontal treatment: fibroblast biology. J Periodontol 2003, 74:103-110.
4. McCarty MF. Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Med Hypotheses 1999, 52:465-477.
5. Moutsopoulos NM, Madianos PN. Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N Y Acad Sci 2006, 1088:251-264.
6. Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003, 149:1-38.
7. Nareika A, Im YB, Game BA. High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities. J Endocrinol 2008, 196:45-55.
8. Flemmig TF. Periodontitis. Ann Periodontol 1999, 4:32-38.
9. Salvi GE, Yalda B, Collins JG. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol 1997, 68:127-135.
10. Lehr HA, Mankoff DA, Corwin D, Santeusanio G, Gown AM. Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer. J Histochem Cytochem 1997, 45:1559-1565.
11. R: a language and environment for statistical computing. 2009, http://www.r-project.org/, R Development Core Team, R Foundation for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0, URL , Accessed on February 1, 2010
12. Broberg P. SAGx: Statistical Analysis of the GeneChip. http://www.bioconductor.org/packages/2.4/bioc/html/SAGx.html, R package version 1.18.0, 2009, URL Accessed on February 1, 2010
13. Hothorn T, Hornik K, van de Wiel MA, Zeileis A. Implementing a class of permutation tests: the coin package. J Stat Softw 2008, 28:1-23.
14. Trevilatto PC, Scarel-Caminaga RM, de Brito RB, de Souza AP, Line SR. Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol 2003, 30:438-442.
15. Tervonen T, Raunio T, Knuuttila M, Karttunen R. Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease. J Clin Periodontol 2007, 34:377-383.
16. Babel N, Cherepnev G, Babel D. Analysis of tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-10, IL-6, and interferon-gamma gene polymorphisms in patients with chronic periodontitis. J Periodontol 2006, 77:1978-1983.
17. Irwin CR, Myrillas TT, Traynor P, Leadbetter N, Cawston TE. The role of soluble interleukin (IL)-6 receptor in mediating the effects of IL-6 on matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts. J Periodontol 2002, 73:741-747.
18. Sundararaj KP, Samuvel DJ, Li Y, Sanders JJ, Lopes-Virella MF, Huang Y. Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking between fibroblasts and U937 macrophages exposed to high glucose. J Biol Chem 2009, 284:13714-13724.
19. Marcaccini AM, Meschiari CA, Sorgi CA. Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. J Periodontol 2009, 80:594-602.
20. Mustapha IZ, Debrey S, Oladubu M, Ugarte R. Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J Periodontol 2007, 78:2289-2302.
21. Paquette DW, Brodala N, Nichols TC. Cardiovascular disease, inflammation, and periodontal infection. Periodontol 2000 2007, 44:113-126.
22. Darwazeh AM. Diabetes mellitus, dental caries and periodontal disease: evidence for a relationship. Dent Health (London) 1990, 29:3-7.
23. Katz PP, Wirthlin MR, Szpunar SM, Selby JV, Sepe SJ, Showstack JA. Epidemiology and prevention of periodontal disease in individuals with diabetes. Diabetes Care 1991, 14:375-385.
24. Yalda B, Offenbacher S, Collins JG. Diabetes as a modifier of periodontal disease expression. Periodontol 2000 1994, 6:37-49.
25. Silva JA, Lorencini M, Reis JR, Carvalho HF, Cagnon VH, Stach-Machado DR. The influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue. Tissue Cell 2008, 40:283-292.
26. Perrino MA. Diabetes and periodontal disease: an example of an oral/systemic relationship. N Y State Dent J 2007, 73:38-41.
27. Maldonado A, He L, Game BA. Pre-exposure to high glucose augments lipopolysaccharide-stimulated matrix metalloproteinase-1 expression by human U937 histiocytes. J Periodontal Res 2004, 39:415-423.
28. Nareika A, Maldonado A, He L. High glucose-boosted inflammatory responses to lipopolysaccharide are suppressed by statin. J Periodontal Res 2007, 42:31-38.
29. Yamazaki K, Nakajima T, Gemmell E, Polak B, Seymour GJ, Hara K. IL-4- and IL-6-producing cells in human periodontal disease tissue. J Oral Pathol Med 1994, 23:347-353.