Synthesis of trypsin-resistant variants of the listeria-active bacteriocin salivaricin P

Applied and Environmental Microbiology

Volumn 76, Issue 16, 2010, Pages 5356-5362

  O'Shea, Eileen F ^a,c   O'Connor, Paula M ^a,b   Cotter, Paul D ^a,b   Paul Ross, R ^a,b   Hill, Colin ^b,c  

^a TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL ACTIVITY; BACTERIOCINS; CLEAVAGE SITES; GASTROINTESTINAL TRACT; LISTERIA MONOCYTOGENES; TRYPSIN DIGESTION; TWO-COMPONENT; WILD TYPES;

DEGRADATION; DISEASES; MICROORGANISMS; PEPTIDES;

LISTERIA;

ANTIINFECTIVE AGENT; BACTERIOCIN; RECOMBINANT PROTEIN; TRYPSIN;

ANTIMICROBIAL ACTIVITY; BACTERIUM; ENZYME ACTIVITY; EXPERIMENTAL STUDY; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; DRUG EFFECT; GENETICS; LISTERIA MONOCYTOGENES; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; SITE DIRECTED MUTAGENESIS; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIOCINS; LISTERIA MONOCYTOGENES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; TRYPSIN;

LISTERIA; LISTERIA MONOCYTOGENES;

EID: 77955943514     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00523-10     Document Type: Article

References (35)

1. Appleyard, A. N., S. Choi, D. M. Read, A. Lightfoot, S. Boakes, A. Hoffmann, I. Chopra, G. Bierbaum, B. A. Rudd, M. J. Dawson, andJ. Cortes. 2009. Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem. Biol. 16:490-498.
2. Barrett, E., M. Hayes, P. O'Connor, G. Gardiner, G. Fitzgerald, C. Stanton, R. P. Ross, andC. Hill. 2007. Salivaricin P: one of a family of two component antilisterial bacteriocins produced by intestinal isolates of Lactobacillus salivarius. Appl. Environ. Microbiol. 73:3719-3723.
3. Bauer, R., andL. M. Dicks. 2005. Mode of action of lipid II-targeting lantibiotics. Int. J. Food Microbiol. 101:201-216.
4. Chen, Y., R. D. Ludescher, andT. J. Montville. 1997. Electrostatic interactions, but not the YGNGV consensus motif, govern the binding of pediocin PA-1 and its fragments to phospholipid vesicles. Appl. Environ. Microbiol. 63:4770-4777.
5. Corr, S. C., Y. Li, C. U. Riedel, P. W. O'Toole, C. Hill, andC. G. Gahan. 2007. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc. Natl. Acad. Sci. U. S. A. 104:7617-7621.
6. Cotter, P. D., L. H. Deegan, E. M. Lawton, L. A. Draper, P. M. O'Connor, C. Hill, andR. P. Ross. 2006. Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol. Microbiol. 62:735-747.
7. Field, D., B. Collins, P. D. Cotter, C. Hill, andR. P. Ross. 2007. A system for the random mutagenesis of the two-peptide lantibiotic lacticin 3147: analysis of mutants producing reduced antibacterial activities. J. Mol. Microbiol. Biotechnol. 13:226-234.
8. Field, D., P. M. O'Connor, P. D. Cotter, C. Hill, andR. P. Ross. 2008. The generation of nisin variants with enhanced activity against specific grampositive pathogens. Mol. Microbiol. 69:218-230.
9. Fimland, G., L. Johnsen, L. Axelsson, M. B. Brurberg, I. F. Nes, V. G. Eijsink, andJ. Nissen-Meyer. 2000. A C-terminal disulfide bridge in pediocin-like bacteriocins renders bacteriocin activity less temperature dependent and is a major determinant of the antimicrobial spectrum. J. Bacteriol. 182:2643-2648.
10. Fimland, G., andJ. Nissen-Meyer. 2007. Genetically modified bacteriocins, p. 43-66. In M. A. Riley and O. Gillor (ed.), Research and applications in bacteriocins. Horizon Bioscience, Wymondham, United Kingdom.
11. Fimland, G., J. Pirneskoski, J. Kaewsrichan, A. Jutila, P. E. Kristiansen, P. K. Kinnunen, andJ. Nissen-Meyer. 2006. Mutational analysis and membrane-interactions of the beta-sheet-like N-terminal domain of the pediocinlike antimicrobial peptide sakacin P. Biochim. Biophys. Acta 1764:1132-1140.
12. Flynn, S., D. van Sinderen, G. M. Thornton, H. Holo, I. F. Nes, andJ. K. Collins. 2002. Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118. Microbiology 148: 973-984.
13. Garneau, S., C. A. Ference, M. J. van Belkum, M. E. Stiles, andJ. C. Vederas. 2003. Purification and characterization of brochocin A and brochocin B(10-43), a functional fragment generated by heterologous expression in Carnobacterium piscicola. Appl. Environ. Microbiol. 69:1352-1358.
14. Haugen, H. S., P. E. Kristiansen, G. Fimland, andJ. Nissen-Meyer. 2008. Mutational analysis of the class IIa bacteriocin curvacin A and its orientation in target cell membranes. Appl. Environ. Microbiol. 74:6766-6773.
15. Islam, M. R., K. Shioya, J. Nagao, M. Nishie, H. Jikuya, T. Zendo, J. Nakayama, andK. Sonomoto. 2009. Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning. Mol. Microbiol. 72:1438-1447.
16. Johnsen, L., G. Fimland, V. Eijsink, andJ. Nissen-Meyer. 2000. Engineering increased stability in the antimicrobial peptide pediocin FA-1. Appl. Environ. Microbiol. 66:4798-4802.
17. Kazazic, M., J. Nissen-Meyer, andG. Fimland. 2002. Mutational analysis of the role of charged residues in target-cell binding, potency and specificity of the pediocin-like bacteriocin sakacin P. Microbiology 148:2019-2027.
18. Keil, B. 1992. Specificity of proteolysis. Springer-Verlag, Berlin, Germany.
19. Levengood, M. R., P. J. Knerr, T. J. Oman, andW. A. van der Donk. 2009. In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J. Am. Chem. Soc. 131:12024-12025.
20. Marciset, O., M. C. Jeronimus-Stratingh, B. Mollet, andB. Poolman. 1997. Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor. J. Biol. Chem. 272:14277-14284.
21. Morgan, S. M., P. M. O'Connor, P. D. Cotter, R. P. Ross, andC. Hill. 2005. Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations. Antimicrob. Agents Chemother. 49:2606-2611.
22. Nissen-Meyer, J., H. Hol, L. S. Havarstein, K. Sletten, andI. F. Nes. 1992. A novel lactococcal bacteriocin whose activity depends on the complementary action of two peptides. J. Bacteriol. 174:5686-5692.
23. Nissen-Meyer, J., P. Rogne, C. Oppegard, H. S. Haugen, andP. E. Kristiansen. 2009. Structure-function relationships of the non-lanthionine- containing peptide (class II) bacteriocins produced by Gram-positive bacteria. Curr. Pharm. Biotechnol. 10:19-37.
24. Oppegard, C., G. Fimland, L. Thorbaek, andJ. Nissen-Meyer. 2007. Analysis of the two-peptide bacteriocins lactococcin G and enterocin 1071 by sitedirected mutagenesis. Appl. Environ. Microbiol. 73:2931-2938.
25. Oppegard, C., J. Schmidt, P. E. Kristiansen, andJ. Nissen-Meyer. 2008. Mutational analysis of putative helix-helix interacting GxxxG-motifs and tryptophan residues in the two-peptide bacteriocin lactococcin G. Biochemistry 47:5242-5249.
26. Ottenwalder, B., T. Kupke, S. Brecht, V. Gnau, J. Metzger, G. Jung, andF. Gotz. 1995. Isolation and characterization of genetically engineered gallidermin and epidermin analogs. Appl. Environ. Microbiol. 61:3894-3903.
27. Rogne, P., G. Fimland, J. Nissen-Meyer, andP. E. Kristiansen. 2008. Threedimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G. Biochim. Biophys. Acta 1784:543-554.
28. Rogne, P., C. Haugen, G. Fimland, J. Nissen-Meyer, andP. E. Kristiansen. 2009. Three-dimensional structure of the two-peptide bacteriocin plantaricin JK. Peptides 30:1613-1621.
29. Ryan, M. P., M. C. Rea, C. Hill, andR. P. Ross. 1996. An application in cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad-spectrum bacteriocin, lacticin 3147. Appl. Environ. Microbiol. 62:612-619.
30. Stern, N. J., E. A. Svetoch, B. V. Eruslanov, V. V. Perelygin, E. V. Mitsevich, I. P. Mitsevich, V. D. Pokhilenko, V. P. Levchuk, O. E. Svetoch, and B. S. Seal. 2006. Isolation of a Lactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system. Antimicrob. Agents Chemother. 50:3111-3116.
31. Tominaga, T., andY. Hatakeyama. 2006. Determination of essential and variable residues in pediocin PA-1 by NNK scanning. Appl. Environ. Microbiol. 72:1141-1147.
32. Vera Pingitore, E., E. M. Hebert, M. E. Nader-Macias, andF. Sesma. 2009. Characterization of salivaricin CRL 1328, a two-peptide bacteriocin produced by Lactobacillus salivarius CRL 1328 isolated from the human vagina. Res. Microbiol. 160:401-408.
33. Walsh, M. C., G. E. Gardiner, O. M. Hart, P. G. Lawlor, M. Daly, B. Lynch, B. T. Richert, S. Radcliffe, L. Giblin, C. Hill, G. F. Fitzgerald, C. Stanton, andP. Ross. 2008. Predominance of a bacteriocin-producing Lactobacillus salivarius component of a five-strain probiotic in the porcine ileum and effects on host immune phenotype. FEMS Microbiol. Ecol. 64:317-327.
34. Wiedemann, I., E. Breukink, C. van Kraaij, O. P. Kuipers, G. Bierbaum, B. de Kruijff, andH. G. Sahl. 2001. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J. Biol. Chem. 276:1772-1779.
35. Yuan, J., Z. Z. Zhang, X. Z. Chen, W. Yang, andL. D. Huan. 2004. Sitedirected mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants. Appl. Microbiol. Biotechnol. 64:806-815.