In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis

Behavioural Pharmacology

Volumn 21, Issue 5-6, 2010, Pages 438-450

  Pinna, Graziano ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

5 reductase type I; aggressive behavior; allopregnanolone; anxiety; GABAA receptors; mouse; post traumatic stress disorder; selective brain steroidogenic stimulants (SBSS); social isolation

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 5ALPHA PREGNANE 3,20 DIONE; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; DIAZEPAM; FGIN 1-27; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; MUSCIMOL; NEUROSTEROID; NORFLUOXETINE; PAROXETINE; PENTOBARBITAL; PICROTOXIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; STEROID; TIANEPTINE; UNCLASSIFIED DRUG; VENLAFAXINE; ZOLPIDEM;

AGGRESSION; ANXIETY DISORDER; BEHAVIOR DISORDER; BIOAVAILABILITY; BIOSYNTHESIS; COMPETITIVE INHIBITION; DEPRESSION; DRUG MECHANISM; DRUG TARGETING; FEAR; GABAERGIC TRANSMISSION; GLUTAMATERGIC TRANSMISSION; HUMAN; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; NERVE CELL; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PANIC; POSTTRAUMATIC STRESS DISORDER; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SEROTONIN UPTAKE; SOCIAL ISOLATION; STEREOISOMERISM; STEROIDOGENESIS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FLUOXETINE; HUMANS; MICE; PREGNANOLONE; RECEPTORS, GABA-A; SEROTONIN UPTAKE INHIBITORS; SOCIAL ISOLATION; STRESS DISORDERS, POST-TRAUMATIC;

EID: 77955930787     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e32833d8ba0     Document Type: Review

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