Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets

Journal of Thoracic and Cardiovascular Surgery

Volumn 140, Issue 3, 2010, Pages 677-683

  Mercier, Olaf ^a   Sage, Edouard ^b   Izziki, Mohammed ^b   Humbert, Marc ^b   Dartevelle, Philippe ^b   Eddahibi, Saadia ^b   Fadel, Elie ^b  

^a Universite Paris Sud   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; MESSENGER RNA; TBC 3711; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; ISOXAZOLE DERIVATIVE; N-(2-ACETYL-4,6-DIMETHYLPHENYL)-3-(3,4-DIMETHYLISOXAZOL-5-YLSULFAMOYL)THIOPHENE-2-CARBOXAMIDE; SULFONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTOPULMONARY SHUNT; APOPTOSIS; ARTERIAL WALL THICKNESS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HEART OUTPUT; LUNG EMBOLISM; NICK END LABELING; NONHUMAN; PIGLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; ANIMAL; AORTA; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEMODYNAMICS; HYPERTENSION, PULMONARY; HYPERTROPHY; LUNG CIRCULATION; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PULMONARY EMBOLISM; SURGERY; SWINE; TIME; VASCULAR SMOOTH MUSCLE;

ANGIOPOIETIN-1; ANIMALS; ANIMALS, NEWBORN; ANTIHYPERTENSIVE AGENTS; AORTA; APOPTOSIS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENDOTHELIN A RECEPTOR ANTAGONISTS; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HEMODYNAMICS; HYPERTENSION, PULMONARY; HYPERTROPHY; ISOXAZOLES; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY EMBOLISM; RECEPTOR, ENDOTHELIN A; RECEPTOR, TIE-2; RNA, MESSENGER; SULFONES; SWINE; TIME FACTORS;

EID: 77955929080     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2010.01.004     Document Type: Article

References (28)

1. M. Riedel, V. Stanek, J. Widimsky, and I. Prerovsky Long-term follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data Chest 81 1982 151 158
2. S.W. Jamieson, D.P. Kapelanski, N. Sakakibara, G.R. Manecke, P.A. Thistlethwaite, and K.M. Kerr Pulmonary endarterectomy: experience and lessons learned in 1,500 cases Ann Thorac Surg 76 2003 1457 1462
3. P. Dartevelle, E. Fadel, A. Chapelier, P. Macchiarini, J. Cerrina, and F. Parquin Angioscopic video-assisted pulmonary endarterectomy for post-embolic pulmonary hypertension Eur J Cardiothorac Surg 16 1999 38 43
4. R.S. Hartz, J.G. Byrne, S. Levitsky, J. Park, and S. Rich Predictors of mortality in pulmonary thromboendarterectomy Ann Thorac Surg 62 1996 1255 1259
5. R. Condliffe, D.G. Kiely, J.S. Gibbs, P.A. Corris, A.J. Peacock, and D.P. Jenkins Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension Am J Respir Crit Care Med 177 2008 1122 1127
6. P. Dartevelle, E. Fadel, S. Mussot, A. Chapelier, P. Hervé, and M. de Perrot Chronic thromboembolic pulmonary hypertension Eur Respir J 23 2004 637 648
7. K.M. Moser, and C.M. Bloor Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension Chest 103 1993 685 692
8. R. Azarian, M. Wartski, M.A. Collignon, F. Parent, P. Hervé, and H. Sors Lung perfusion scans and hemodynamics in acute and chronic pulmonary embolism J Nucl Med 38 1997 980 983
9. E.S. Yi, H. Kim, H. Ahn, J. Strother, T. Morris, and E. Masliah Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study Am J Respir Crit Care Med 162 4 Pt 1 2000 1577 1586
10. M.M. Hoeper, E. Mayer, G. Simonneau, and L.J. Rubin Chronic thromboembolic pulmonary hypertension Circulation 113 2006 2011 2020
11. P. Egermayer, and A.J. Peacock Is pulmonary embolism a common cause of chronic pulmonary hypertension? Limitations of the embolic hypothesis Eur Respir J 15 2000 440 448
12. K.M. Moser, and N.S. Braunwald Successful surgical intervention in severe chronic thromboembolic pulmonary hypertension Chest 64 1973 29 35
13. A. Peacock, G. Simonneau, and L. Rubin Controversies, uncertainties and future research on the treatment of chronic thromboembolic pulmonary hypertension Proc Am Thorac Soc 3 2006 608 614
14. E.G. Anderson, G. Simon, and L. Reid Primary and thromboembolic pulmonary hypertension: a quantitative pathological study J Pathol 110 1972 273 293
15. D. Heath, and J.E. Edwards The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects Circulation 18 1958 533 547
16. B. Rondelet, F. Kerbaul, S. Motte, R. van Beneden, M. Remmelink, and S. Brimioulle Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension Circulation 107 2003 1329 1335
17. V.M. Reddy, J. Wong, J.R. Liddicoat, M. Johengen, R. Chang, and J.R. Fineman Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow Am J Physiol 271 1996 H562 H570
18. B. Ovadia, O. Reinhartz, R. Fitzgerald, J.M. Bekker, M.J. Johengen, and A. Azakie Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow Am J Physiol Heart Circ Physiol 284 2003 H480 H490
19. S.M. Black, J.R. Fineman, R.H. Steinhorn, J. Bristow, and S.J. Soifer Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension Am J Physiol 275 1998 H1643 H1651
20. N. Gali, and N.H. Kim Pulmonary microvascular disease in chronic thromboembolic pulmonary hypertension Proc Am Thorac Soc 3 2006 571 576
21. O. Mercier, E. Sage, M. de Perrot, L. Tu, E. Marcos, and B. Decante Regression of flow-induced pulmonary arterial vasculopathy after flow correction in piglets J Thorac Cardiovasc Surg 137 2009 1538 1546
22. C. Wu, E.R. Decker, N. Blok, H. Bui, T.J. You, and J. Wang Discovery, modeling, and human pharmacokinetics of N-(2 acetyl-4,6-dimethylphenyl)-3-(3,4- dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist J Med Chem 47 2004 1969 1986
23. T. Perreault, J.W. Berkenbosch, K.J. Barrington, E.R. Decker, C. Wu, and T.A. Brock TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets Pediatr Res 50 2001 374 383
24. P. Bresser, J. Pepke-Zaba, X. Jaïs, M. Humbert, and M.M. Hoeper Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm Proc Am Thorac Soc 3 2006 594 600
25. D. Bonderman, R. Nowotny, N. Skoro-Sajer, J. Jakowitsch, C. Adlbrecht, and W. Klepetko Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension Chest 128 2005 2599 2603
26. M.M. Hoeper, T. Kramm, H. Wilkens, C. Schulze, H.J. Schäfers, and T. Welte Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension Chest 128 2005 2363 2367
27. R.J. Hughes, X. Jais, D. Bonderman, J. Suntharalingam, M. Humbert, and I. Lang The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study Eur Respir J 28 2006 138 143
28. X. Jaïs, A.M. D'Armini, P. Jansa, A. Torbicki, M. Delcroix, H.A. Ghofrani Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronic Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial J Am Coll Cardiol 52 2008 2127 2134