Determination of quinolizidine alkaloids in different Lupinus species by NACE using UV and MS detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 5, 2010, Pages 1231-1235

  Ganzera, Markus ^a   Krüger, Anja ^a   Wink, Michael ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Capillary electrophoresis mass spectrometry; Lupinus species; Non aqueous capillary electrophoresis; Quantification; Quinolizidine alkaloids

Indexed keywords

ACETIC ACID; ACETONITRILE; ALKALOID; AMMONIUM FORMATE; BUFFER; LUPANINE; METHANOL; QUINOLIZIDINE DERIVATIVE; SPARTEINE; WATER;

ACCURACY; ARTICLE; ELECTRIC POTENTIAL; HUMAN; LUPIN; NONAQUEOUS CAPILLARY ELECTROPHORESIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; TEMPERATURE; ULTRAVIOLET RADIATION;

ALKALOIDS; ELECTROPHORESIS, CAPILLARY; LUPINUS; PLANT EXTRACTS; QUINOLIZIDINES; SEEDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 77955922884     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.05.030     Document Type: Article

References (20)

1. Sujak A., Kotlarz A., Strobel W. Compositional and nutritional evaluation of several lupin seeds. Food Chem. 2006, 98:711-719.
2. Reinhard H., Rupp H., Sager F., Streule M., Zoller O. Quinolizidine alkaloids and phomopsins in lupin seeds and lupin containing food. J. Chromatogr. A 2006, 1112:353-360.
3. Resta D., Boschin G., D'Agostina A., Arnoldi A. Evaluation of total quinolizidine alkaloid content in lupin flours, lupin-based ingredients, and foods. Mol. Nutr. Food Res. 2008, 52:490-495.
4. Roberts M.F., Wink M. Alkaloids: Biochemistry, Ecology and Medicinal Applications 1998, Plenum Press, New York, pp. 265-300.
5. Pothier J., Cheav L., Galand N., Viel C. A comparative study of the effects of sparteine, lupanine and lupin extract on the central nervous system of the mouse. J. Pharm. Pharmacol. 1998, 50:949-954.
6. Banuelos P.J., Nolasco R.G., Monteon J.A., Garcia Lopez P.M., Ruiz Lopez M.A., Garcia Estrada J. Histological evaluation of brain damage caused by crude quinolizidine alkaloid extracts from lupines. Histol. Histopathol. 2005, 20:1147-1153.
7. Lee S.T., Cook D., Panter K.E., Gardener D.R., Ralphs M.H., Motteram E.S., Pfister J.A., Gay C.C. Lupine induced " crooked calf disease" in Washington and Oregon: identification of the alkaloid profiles in Lupinus sulfureus, Lupinus leucophyllus and Lupinus sericeus. J. Agric. Food Chem. 2007, 55:10649-10655.
8. Wink M., Meißner C., Witte L. Patterns of quinolizidine alkaloids in 56 species of the genus Lupinus. Phytochemistry 1995, 38:139-153.
9. Chludil H.D., Vilarino M., Franco M.L., Leicach S.R. Changes in Lupinus albus and Lupinus angustifolius profiles in response to mechanical damage. J. Agric. Food Chem. 2009, 57:6107-6113.
10. Erdemoglu N., Ozkan S., Tosun F. Alkaloid profile and antimicrobial activity of Lupinus angustifolius L. alkaloid extract. Phytochem. Rev. 2007, 6:197-201.
11. Boschin G., Annicchiarico P., Resta D., D'Agostina A., Arnoldi A. Quinolizidine alkaloids in seeds of lupin genotypes of different origins. J. Agric. Food Chem. 2008, 56:3657-3663.
12. Wink M. Quinolizidine alkaloids. Methods in Plant Biochemistry 1993, vol. 8:197-239. Academic Press, London.
13. Chen X., Yi C., Li M., Lu X., Li Z., Li P., Wang X. Determination of sophoridine and related lupin alkaloids using tris(2,2'-bipyridine)ruthenium electrogenerated chemiluminescence. Anal. Chim. Acta 2002, 446:79-86.
14. Gavrilin M.V., Senchenko S.P., Popova O.I. Extraction-photometric determination of alkaloids in lupine seeds. Pharm. Chem. J. 2006, 40:272-275.
15. Pothier J., Petit-Paly G., Montagu M., Galand N., Chenieux J.C., Rideau M., Viel C. Separation of quinolizidine and dihydrofuro[2,3-b]quinolinium alkaloids by overpressured layer chromatography (OPLC). J. Planar Chromatogr. 1990, 3:356-358.
16. Von Baer D., Saelzer R., Vega M., Ibieta P., Molina L., von Baer E., Ibanez R., Hashagen U. Isovlavones in Lupinus albus and Lupinus angustifolius: quantitative determination by capillary zone electrophoresis, evolution of their content during plant development and effect of anthrocynose causing fungus Colletrotrichum lupini. J. Chil. Chem. Soc. 2006, 51:1025-1029.
17. Ganzera M. Quality control of herbal medicines by capillary electrophoresis - potential, requirements and applications. Electrophoresis 2008, 29:3489-3503.
18. Yu Y, Ding P., Chen D. Determination of quinolizidine alkaloids in Sophora medicinal plants by capillary electrophoresis. Anal. Chim. Acta 2004, 523:15-20.
19. Song J.Z., Xu H.X., Tian S.J., But P.P. Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis. J. Chromatogr. A 1999, 857:303-311.
20. de Cortes S., Altares P., Pedrosa M., Burbano C., Cuadrado C., Goyoaga C., Muzquiz M., Jimenez-Martinez C., Davila-Ortiz G. Alkaloid variation during germination in different lupin species. Food Chem. 2005, 90:347-355.