Low-concentration tributyltin perturbs inhibitory synaptogenesis and induces neuronal death in immature but not mature neurons

Toxicology Letters

Volumn 198, Issue 2, 2010, Pages 282-288

  Yamada, Junko ^a   Inoue, Koichi ^b   Furukawa, Tomonori ^b   Fukuda, Atsuo ^b  

^a HIROSAKI UNIVERSITY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chloride homeostasis; GABA; Inhibitory postsynaptic current; Neurotoxicity; Tributyltin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE ION; TRIBUTYLTIN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CULTURAL ANTHROPOLOGY; CYTOTOXICITY; ELECTRIC POTENTIAL; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; HOMEOSTASIS; IN VITRO STUDY; MOUSE; NEOCORTEX; NERVE CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; ONTOGENY; PATCH CLAMP; PRIORITY JOURNAL; SYNAPTOGENESIS; WHOLE CELL;

ANIMALS; ANTIPORTERS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGICAL PHENOMENA; EMBRYONIC DEVELOPMENT; ENVIRONMENTAL POLLUTANTS; GESTATIONAL AGE; MICE; MICE, INBRED ICR; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A; SYNAPTIC POTENTIALS; SYNAPTIC TRANSMISSION; TRIALKYLTIN COMPOUNDS;

INVERTEBRATA; MAMMALIA;

EID: 77955921070     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.07.011     Document Type: Article

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