Antidotes for alcohol and glycol toxicity: Translating mechanisms into treatments

Clinical Pharmacology and Therapeutics

Volumn 88, Issue 3, 2010, Pages 400-404

  McMartin, K E ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ETHYLENE GLYCOL;

ALCOHOL INTOXICATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG MARKETING; DRUG METABOLISM; DRUG RESEARCH; DRUG SYNTHESIS; HUMAN; METHANOL POISONING; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; UNSPECIFIED SIDE EFFECT;

ANIMALS; ANTIDOTES; CLINICAL TRIALS AS TOPIC; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ETHYLENE GLYCOL; HUMANS; METHANOL; PYRAZOLES; TRANSLATIONAL RESEARCH;

EID: 77955920753     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.157     Document Type: Short Survey

References (30)

1. th Annual Report. Clin. Toxicol. (Phila). 47, 911-1084 (2009).
2. Jacobsen, D. & McMartin, K.E. Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment. Med. Toxicol. 1, 309-334 (1986).
3. Dial, S.M., Thrall, M.A. & Hamar, D.W. 4-Methylpyrazole as treatment for naturally acquired ethylene glycol intoxication in dogs. J. Am. Vet. Med. Assoc. 195, 73-76 (1989).
4. McMartin, K.E., Martin-Amat, G., Makar, A.B. & Tephly, T.R. Methanol poisoning. V. Role of formate metabolism in the monkey. J. Pharmacol. Exp. Ther. 201, 564-572 (1977).
5. Martin-Amat, G., McMartin, K.E., Hayreh, S.S., Hayreh, M.S. & Tephly, T.R. Methanol poisoning: ocular toxicity produced by formate. Toxicol. Appl. Pharmacol. 45, 201-208 (1978).
6. Jacobsen, D., Ovrebø, S., Ostborg, J. & Sejersted, O.M. Glycolate causes the acidosis in ethylene glycol poisoning and is efectively removed by hemodialysis. Acta Med. Scand. 216, 409-416 (1984).
7. Guo, C., Cenac, T.A., Li, Y. & McMartin, K.E. Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol. Toxicol. Lett. 173, 8-16 (2007).
8. Li, T.K. & Theorell, H. Human liver alcohol dehydrogenase: inhibition by pyrazole and pyrazole analogs. Acta Chem. Scand. 23, 892-902 (1969).
9. Blomstrand, R. & Theorell, H. Inhibitory efect on ethanol oxidation in man after administration of 4-methylpyrazole. Life Sci. II 9, 631-640 (1970).
10. Magnusson, G., Nyberg, J.A., Bodin, N.O. & Hansson, E. Toxicity of pyrazole and 4-methylpyrazole in mice and rats. Experientia 28, 1198-1200 (1972).
11. Blomstrand, R. & Forsell, L. Prevention of the acute ethanol-induced fatty liver by 4-methylpyrazole. Life Sci. II 10, 523-530 (1971).
12. Salaspuro, M.P., Pikkarainen, P. & Lindros, K. Ethanol-induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4-methylpyrazole. Eur. J. Clin. Invest. 7, 487-490 (1977).
13. McMartin, K.E., Makar, A.B., Martin, G., Palese, M. & Tephly, T.R. Methanol poisoning. I. The role of formic acid in the development of metabolic acidosis In the monkey and the reversal by 4-methylpyrazole. Biochem. Med. 13, 319-333 (1975).
14. McMartin, K.E., Hedström, K.G., Tolf, B.R., Ostling-Wintzell, H. & Blomstrand, R. Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model. Arch. Biochem. Biophys. 199, 606-614 (1980).
15. Chou, J.Y. & Richardson, K.E. The efect of pyrazole on ethylene glycol toxicity and metabolism in the rat. Toxicol. Appl. Pharmacol. 43, 33-44 (1978).
16. Grauer, G.F., Thrall, M.A., Henre, B.A. & Hjelle, J.J. Comparison of the efects of ethanol and 4-methylpyrazole on the pharmacokinetics and toxicity of ethylene glycol in the dog. Toxicol. Lett. 35, 307-314 (1987).
17. Barceloux, D.G., Krenzelok, E.P., Olson, K. & Watson, W. American Academy of Clinical toxicology practice Guidelines on the treatment of Ethylene Glycol poisoning. Ad Hoc Committee. J. Toxicol. Clin. Toxicol. 37, 537-560 (1999).
18. Jacobsen, D., Sebastian, C.S., Blomstrand, R. & McMartin, K.E. 4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. Alcohol. Clin. Exp. Res. 12, 516-522 (1988).
19. Jacobsen, D., Sebastian, C.S., Barron, S.K., Carriere, E.W. & McMartin, K.E. Efects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. J. Emerg. Med. 8, 455-461 (1990).
20. Jacobsen, D. et al. Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans. Alcohol. Clin. Exp. Res. 20, 804-809 (1996).
21. Murphy, R.C. & Watkins, W.D. pharmacology of pyrazoles. I. structure elucidation of metabolites of 4-methylpyrazole. Biochem. Biophys. Res. Commun. 49, 283-291 (1972).
22. Winters, D.K. & Cederbaum, A.I. time course characterization of the induction of cytochrome p-450 2E1 by pyrazole and 4-methylpyrazole. Biochim. Biophys. Acta 1117, 15-24 (1992).
23. Jacobsen, D., Barron, S.K., Sebastian, C.S., Blomstrand, R. & McMartin, K.E. Non-linear kinetics of 4-methylpyrazole in healthy human subjects. Eur. J. Clin. Pharmacol. 37, 599-604 (1989).
24. Marrafa, J., Forrest, A., Grant, W., Stork, C., McMartin, K. & Howland, M.A. Oral administration of fomepizole produces similar blood levels as identical intravenous dose. Clin. Toxicol. (Phila). 46, 181-186 (2008).
25. Baud, F.J. et al. 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. J. Toxicol. Clin. Toxicol. 24, 463-483 (1986).
26. Brent, J. et al. Fomepizole for the treatment of ethylene glycol poisoning. N. Engl. J. Med. 340, 832-838 (1999).
27. Brent, J., McMartin, K., Phillips, S., Aaron, C. & Kulig, K. Fomepizole for the treatment of methanol poisoning. N. Engl. J. Med. 344, 424-429 (2001).
28. Pietruszko, R. Human liver alcohol dehydrogenase-inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Biochem. Pharmacol. 24, 1603-1607 (1975).
29. Brent, J. Fomepizole for ethylene glycol and methanol poisoning. N. Engl. J. Med. 360, 2216-2223 (2009).
30. McMartin, K. Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning? Clin. Toxicol. (Phila). 47, 859-869 (2009).