The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol

Pharmacogenetics and Genomics

Volumn 20, Issue 9, 2010, Pages 553-564

  Downing, Chris ^a   Marks, Michael J ^a   Larson, Colin ^a   Johnson, Thomas E ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

2 methyl 6 (phenylethyl) pyridine; alcohol; loss of righting reflex; metabotropic glutamate receptor subtype 5; quantitative complementation

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALCOHOL; MESSENGER RNA; METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; INBRED STRAIN; INTRON; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RIGHTING REFLEX; SEDATION; SINGLE NUCLEOTIDE POLYMORPHISM;

MUS;

EID: 77955920652     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32833d8c20     Document Type: Article

References (60)

1. McClearn GE, Kakihana R. Selective breeding for ethanol sensitivity: short-sleep and long-sleep mice. In: McClearn GE, Deitrich RA, Erwin VG, editors. Development of animal models as pharmacogenetic tools. Washington, DC: NIAAA Research Monograph No. 6, US Department of Health and Human Services; 1981. pp. 147-159.
2. DeFiebre CM, Marley RJ, Miner LL, deFiebre N, Wehner JM, Collins AC. Classical genetic analyses of responses to sedative-hypnotic drugs in crosses derived from long-sleep and short-sleep mice. Alcohol Clin Exp Res 1992; 16:511-521.
3. Marley RJ, Miner LL, Wehner JM, Collins AC. Differential effects of central nervous system depressants in long-sleep and short-sleep mice. J Pharmacol Exp Ther 1986; 238:1028-1033.
4. Simpson VJ, Rikke BA, Costello JM, Corley R, Johnson TE. Identification of a genetic region in mice that specifies sensitivity to propofol. Anesthesiology 1998; 88:379-389.
5. Wehner JM, Pounder JI, Parham C, Collins AC. A recombinant inbred strain analysis of sleep-time responses to several sedative-hypnotics. Alcohol Clin Exp Res 1992; 16:522-528.
6. DeFries J, Wilson JR, Erwin VG, Petersen DR. LS x SS recombinant inbred strains of mice: initial characterization. Alcohol Clin Exp Res 1989; 13:196-202.
7. Markel PD, Corley RP A multivariate analysis of repeated measures: linkage of the albinism gene (Tyr) to aQTL influencing ethanol-induced anesthesia in laboratory mice. Psych Genet 1994; 4:205-210.
8. Downing C, Shen EH, Simpson VJ, Johnson TE. Mapping quantitative trait loci mediating sensitivity to etomidate. Mammal Genome 2003; 14:367-375.
9. Rikke BA, Simpson VJ, Montoliu L, Johnson TE. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 2001; 25:171-176.
10. Balschun D, Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol Biochem Behav 2002; 73:375-380.
11. Jia Z, Lu YM, Henderson J, Taverna F, Romano C, Abramow-Newerly W, et al. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem 1998; 5:331-343.
12. Jia Z, Lu YM, Agopyan N, Roder J. Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory. Physiol Behav 2001; 73:793-802.
13. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 1997; 17:5196-5205.
14. Rodrigues SM, Bauer EP, Farb CR, Schafe GE, LeDoux JE. The group 1 metabotropic receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J Neurosci 2002; 22:5219-5229.
15. Olive MF. mGlu5 receptors: neuroanatomy, pharmacology and role in drug addiction. Curr Psychiatry Rev 2005; 1:197-214.
16. Olive MF. Metabotropic glutamate receptor ligands as potential therapeutics for addiction. Curr Drug Abuse Rev 2009; 2:83-98.
17. Minami K, Gereau IV RW, Minami M, Heinemann SF, Harris RA. Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 1998; 53:148-156.
18. Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 2004; 29:921-928.
19. Besheer J, Stevenson RA, Hodge CW. mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats. Eur J Pharm 2006; 551:71-75.
20. Besheer J, Faccidomo S, Grondin J, Hodge CW. Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol Clin Exp Res 2008; 32:209-221.
21. Hodge CW, Miles MF, Sharko A, Stevenson RA, Hillmann JR, Lepoutre V, et al. The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacol 2005; 183:429-438.
22. McGeehan AJ, Olive MF. The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse 2003; 47:240-242.
23. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, et al. The mGluR5 antagonist MPEP decreases ethanol consumption via a PKC (epsilon)-dependent mechanism. Mol Pharmacol 2005; 67:349-355.
24. Sharko AC, Hodge CW. Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice. Alcohol Clin Exp Res 2008; 32:67-76.
25. Schroeder JP, Overstreet DH, Hodge CW. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacol 2005; 179:262-270.
26. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK. Behavioral and neurochemical interactions between group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend 2006; 85:142-156.
27. Bird MK, Kirchhoff J, Dlouma E, Lawrence AJ. Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice. Int J Neuropsychopharm 2008; 11:765-774.
28. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci\USA 1993; 90:8424-8428.
29. Bennett B, Beeson M, Gordon L, Johnson TE. Reciprocal congenics defining individual quantitative trait loci for sedative/hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 2002a; 26:149-157.
30. Long AD, Mullaney SL, Mackay TFC, Langley CH. Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number drosophila melanogaster. Genetics 1996; 144:1497-1510.
31. Mackay TFC. Complementing complexity. Nature Genet 2004; 36: 1145-1147.
32. Rikke BA, Johnson TE. Towards the cloning of genes underlying murine QTLs. Mamm Genome 1998; 9:963-968.
33. Corti C, Clarkson RWE, Crepaldi L, Sala CF, Xuereb JH, Ferraguti F. Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. J Biol Chem 2003; 29:33105-33119.
34. -DDCT method. Methods 2001; 25:402-408.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265-275.
36. Dudek BC, Abbott ME. A biometrical genetic analysis of ethanol response in selectively bred long-sleep and short-sleep mice. Behav Genet 1984; 14:1-19.
37. Dudek BC, Abbott ME, Phillips TJ. Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol. Psychopharmacol 1984; 82:46-51.
38. Dudek BC, Phillips TJ. Distinctions among sedative, disinhibitory, and ataxic properties of ethanol in inbred and selectively bred mice. Psychopharmacol 1990; 101:93-99.
39. Szatkiewicz JP, Beane GL, Ding Y, Hutchins L, Pardo-Manuel de Villena F, Churchill GA. An imputed genotype resource for the laboratory mouse. Mamm Genome 2008; 19:199-208.
40. Joly C, Gomeza J, Brabet I, Curry K, Bockaert J, Pin JP. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGlu1. J Neurosci 1995; 15:3970-3981.
41. Bennett B, Carosone-Link P. Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts. Genes Brain Behav 2006; 5:404-412.
42. Haughey HM, Kaiser AL, Johnson TE, Bennett B, Sikela JM, Zahniser NR. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 2005; 29:1759-1768.
43. Sou JH, Chan MH, Chen HH. Ketamine, but not propofol, anesthesia is regulated by metabotropic glutamate 5 receptors. Br J Anaesthesia 2006; 96:597-601.
44. Downing C, Bennett B, Johnson TE. Murine models of alcoholism: from QTL to gene. In: Peltz G, editor. Computational genetics and genomics, tools for understanding disease. New Jersey: Humana Press; 2005. pp. 199-252.
45. Blednov Y, Harris RA. Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. Int J Neuropsychopharm 2008; 11:775-793.
46. O'Shea M, Maytham EG, Linehan JM, Brandner S, Collinge J, Lloyd SE. Investigation of Mcp1 as a quantitative trait gene for prion disease incubation time in mouse. Genetics 2008; 180:559-566.
47. Steingrimsson E, Arnheiter H, Hallsson JH, Lamoreux ML, Copeland NG, Jenkins NA. Interallelic complementation at the mouse Mitf locus. Genetics 2003; 163:267-276.
48. Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, et al. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biology 2007; 5:e297.
49. Yalcin B, Willis-Owen SAG, Fullerton J, Meesaq A, Deacon RM, Rawlins JNP, et al. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nature Genet 2004; 36:1197-1202.
50. Mackay TFC. The genetic architecture of quantitative traits. Annu Rev Genet 2001; 35:303-339.
51. Heidbreder CA, Bianchi M, Lacroix LP, Faedo S, Perdona E, Remelli R, et al. Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse 2003; 50:269-276.
52. Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PGM, Knoblach SM, et al. mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2- phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharm Exp Ther 2001; 296:41-47.
53. Li S-C, Tang P, Lin W-C. Intronic MicroRNA: discovery and biological implications. DNA Cell Biol 2007; 26:195-207.
54. Zhou H, Lin K. Excess of microRNAs in large and very 5 biased introns. Biochem Biophys Res Comm 2008; 368:709-715.
55. Schuckit MA. Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 1994; 151:184-189.
56. Schuckit MA, Smith TL. Assessing the risk for alcoholism among sons of alcoholics. J Stud Alcohol 1997; 58:141-145.
57. Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, et al. A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res 2001; 25:323-329.
58. Schuckit MA, Smith TL, Kalmijn J. The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. Alcohol Clin Exp Res 2004; 28:1449-1458.
59. Wilhelmsen KC, Schuckit MA, Smith TL, Lee JV, Segall SK, Feiler HS, et al. The search for genes related to low-level response to alcohol determined by alcohol challenges. Alcohol Clin Exp Res 2003; 27:1041-1047.
60. Schumann G, Johann F, Frank J, Preuss U, Dahmen N, Laucht M, et al. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Arch Gen Psychiatry 2008; 65:826-838.