Predicting variability of aquatic concentrations of human pharmaceuticals

Science of the Total Environment

Volumn 408, Issue 20, 2010, Pages 4504-4510

  Kostich, Mitchell S ^a   Batt, Angela L ^a   Glassmeyer, Susan T ^a   Lazorchak, James M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Antibiotic; Aquatic; Drinking water; Pharmaceutical; Wastewater

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; AQUATIC; AQUATIC ENVIRONMENTS; COMMONLY USED; DRINKING WATER; ENVIRONMENTAL CONCENTRATION; EXPOSURE RATE; PHARMACEUTICAL; POTENTIAL EXPOSURE; PREDICTED ENVIRONMENTAL CONCENTRATIONS; PRODUCTION RATES;

CONCENTRATION (PROCESS); MARKETING; POTABLE WATER; WASTEWATER;

ANTIBIOTICS;

AMPHETAMINE; ANTIBIOTIC AGENT; ATENOLOL; AZITHROMYCIN; BETAMETHASONE; CIPROFLOXACIN; CITALOPRAM; CODEINE; DRINKING WATER; ETHINYLESTRADIOL; FENTANYL; GEMFIBROZIL; HYDROCHLOROTHIAZIDE; HYDROCODONE; HYDROMORPHONE; IBUPROFEN; MESTRANOL; METFORMIN; METHADONE; METHYLPHENIDATE; MORPHINE; NAPROXEN; NORETHISTERONE; OFLOXACIN; OXYCODONE; PROPRANOLOL; TRIMETHOPRIM; WARFARIN; DRUG; WATER POLLUTANT;

ANTIBIOTICS; AQUATIC ENVIRONMENT; CONCENTRATION (COMPOSITION); DRINKING WATER; DRUG; MARKETING; WASTEWATER;

AQUATIC ENVIRONMENT; ARTICLE; CHEMICAL OXYGEN DEMAND; CONTROLLED STUDY; PEER REVIEW; PREDICTION; PRESCRIPTION; PRIORITY JOURNAL; WASTE WATER; WASTE WATER TREATMENT PLANT; WATER CONTAMINATION; ANALYSIS; ENVIRONMENTAL MONITORING; FORECASTING; HUMAN; KINETICS; PROCEDURES; SEWAGE; STATISTICS AND NUMERICAL DATA; WATER POLLUTANT; WATER POLLUTION;

ENVIRONMENTAL MONITORING; FORECASTING; HUMANS; KINETICS; PHARMACEUTICAL PREPARATIONS; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL; WATER POLLUTION, CHEMICAL;

UNITED STATES;

APIS;

EID: 77955918412     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2010.06.015     Document Type: Article

References (20)

1. Barber L.B., Brown G.K., Zaugg S.D. Analysis of environmental endocrine disruptors. ACS Symposium Series 2002, 747:97-123. American Chemical Society, Washington, DC. L.H. Keith, T.L. Jones-Lepp, L.L. Needham (Eds.).
2. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ Health Perspect 1999, 107(Supplement 6):907-938.
3. Davison A.C., Hinkley D.V. Bootstrap methods and their applications 1997, 202-211. Cambridge University Press, Cambridge;.
4. Doig I., Cordy C. A review of controlled substances. Med Health, RI; 2004, 87(6):186-188.
5. Ericson J.F., Laenge R., Sullivan D.E. Comment on "Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999-2000: A National Reconnaissance". Environ Sci Technol 2002, 36(18):4005-4006.
6. Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 2006, 76(2):122-159.
7. Gros M., Petrovic M., Barcelo D. Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review. Anal Bioanal Chem 2006, 386:941-952.
8. Hignite C., Azaznoff D.L. Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sci 1977, 20:337-342.
9. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol 2002, 36(6):1202-1211.
10. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., et al. Response to comment on "Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance". Environ Sci Technol 2002, 36(18):4007-4008.
11. Kostich M.S., Lazorchak J.M. Risks to aquatic organisms posed by human pharmaceutical use. Sci Total Environ 2008, 389(2-3):329-339.
12. National Drug Intelligence Center Methamphetamine drug threat assessment. Product no. 2005-Q0317-009 2005, US Department of Justice, Johnstown, PA, USA.
13. R Development Core Team R: a language and environment for statistical computing 2008, R Foundation for Statistical Computing, Vienna, Austria, http://www.R-project.org.
14. Richardson M.L., Bowron J.M. The fate of pharmaceutical chemicals in the aquatic environment. J Pharm Pharmacol 1985, 37(1):1-12.
15. Sinnott R.W. Virtues of the haversine. Sky Telescope 1984, 68(2):159-170.
16. US Census Bureau Year 2000 US census zip-code tabulation areas 2000, [Accessed September 17, 2008. ].
17. US DEA Automation of reports and consolidated orders system 2004, [Accessed July 15, 2008. ].
18. US EPA Clean watersheds needs survey 2004, [Accessed September 24, 2008. ].
19. US FDA Approved drug products with therapeutic equivalence evaluations 2009, Washington, DC, USA, US Department of Health and Human Services. 29th edition.
20. Venables W.N., Ripley B.D. Modern applied statistics with S 2002, Springer, New York, New York, USA. Fourth edition.