On the derivation and clinical implications of "driver" mutations in lung cancer

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 1, 2010, Pages 4-5

  Batra, Raj K ^a   Warburton, David ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX2; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CHROMOSOME 3Q; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE COURSE; DISEASE MARKER; EDITORIAL; EMBRYONIC STEM CELL; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; LUNG SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SINGLE NUCLEOTIDE POLYMORPHISM; TRACHEOBRONCHIAL TREE; GENETICS; LUNG TUMOR; MUTATION; NOTE; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; PLEURA EFFUSION; SQUAMOUS CELL CARCINOMA;

CELL DIFFERENTIATION; GENE AMPLIFICATION; HUMANS; LUNG NEOPLASMS; MUTATION; NEOPLASMS, SQUAMOUS CELL; PHENOTYPE; PLEURAL EFFUSION, MALIGNANT; SOXB1 TRANSCRIPTION FACTORS;

EID: 77955916591     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201003-0381ED     Document Type: Editorial

References (7)

1. McCaughan F, Pole JCM, Bankier AT, Konfortov BA, Carroll B, Flazon M, Rabbitts TH, George PJ, Dear PH, Rabbitts PH. Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med 2010;182:83-91.
2. Que J, Luo X, Schwartz RJ, Hogan BL. Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009;136:1899-1907.
3. Okubo T, Clark C, Hogan BL. Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. Stem Cells 2009;27:442-450.
4. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872.
5. Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009;41:1238-1242.
6. Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembele D, Martinet N, Thibault C, Huelsken J, Brambilla E, et al. SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS ONE 2010;5:e8960.
7. Basak SK, Veena MS, Oh S, Huang G, Srivatsan E, Huang M, Sharma S, Batra RK. The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer. PLoS ONE 2009;4:e5884.