3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters

Toxicological Sciences

Volumn 117, Issue 1, 2010, Pages 1-3

  Safe, Stephen ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

AhR; AhR binding sites; ChIP; Ligand differences

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; PROMOTER REGION;

CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; HUMANS; METHYLCHOLANTHRENE; PROMOTER REGIONS, GENETIC; RECEPTORS, ARYL HYDROCARBON;

EID: 77955916547     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq193     Document Type: Article

References (14)

1. Abdelrahim, M., Ariazi, E., Kim, K., Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Hill, D., Finnell, R. H., Wlodarczyk, B., et al. (2006). 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor α. Cancer Res. 66, 2459-2467.
2. Ahmed, S., Valen, E., Sandelin, A., and Matthews, J. (2009). Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Toxicol. Sci. 111, 254-266.
3. Bannister, R., Biegel, L., Davis, D., Astroff, B., and Safe, S. (1989). 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology 54, 139-150.
4. Denison, M. S., and Nagy, S. R. (2003). Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43, 309-334.
5. Dusell, C. D., Nelson, E. R., Wittmann, B. M., Fretz, J. A., Kazmin, D., Thomas, R. S., Pike, J. W., and McDonnell, D. P. (2010). Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol. Endocrinol. 24, 33-46.
6. Gouedard, C., Barouki, R., and Morel, Y. (2004). Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol. Cell Biol. 24, 5209-5222.
7. Gu, Y. Z., Hogenesch, J. B., and Bradfield, C. A. (2000). The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40, 519-561.
8. Jordan, V. C. (2009). A century of deciphering the control mechanisms of sex steroid action in breast and prostate cancer: the origins of targeted therapy and chemoprevention. Cancer Res. 69, 1243-1254.
9. Katzenellenbogen, J. A., O'Malley, B. W., and Katzenellenbogen, B. S. (1996). Tripartite steroid hormone receptor pharmacology-interaction with multiple effector sites as a basis for the cell-and promoter-specific action of these hormones. Mol. Endocrinol. 10, 119-131.
10. Kinehara, M., Fukuda, I., Yoshida, K., and Ashida, H. (2008). High-throughput evaluation of aryl hydrocarbon receptor-binding sites selected via chromatin immunoprecipitation-based screening in Hepa-1c1c7 cells stimulated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Genes Genet. Syst. 83, 455-468.
11. McDougal, A., Wormke, M., Calvin, J., and Safe, S. (2001). Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective Ah receptor modulator. Cancer Res. 61, 3901-3907.
12. Pansoy, A., Ahmed, S., Valen, E., Sandelin, A., and Matthews, J. (2010). 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol. Sci. Advance Access published on March 26, 2010; doi:10.1093/toxsci/kfq096.
13. H17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71.
14. Safe, S., and Kim, K. (2008). Non-classical genomic estrogen receptor (ER)/ specificity protein and ER/activating protein-1 signaling pathways. J. Mol. Endocrinol. 41, 263-275.