Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome

Journal of Pediatric Hematology/Oncology

Volumn 32, Issue 5, 2010, Pages e207-e209

  Sorrentino, Stefania ^a   Conte, Massimo ^a   Nozza, Paolo ^a   Granata, Claudio ^a   Capra, Valeria ^a   Avanzini, Stefano ^a   Garaventa, Alberto ^a  

^a G GASLINI INSTITUTE   (Italy)

Author keywords

Adrenal mass; Beckwith wiedemann syndrome; Congenital neuroblastoma; Cystic pancreatoblastoma

Indexed keywords

ADULT; ARTICLE; BECKWITH WIEDEMANN SYNDROME; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; FEMALE; FETUS ECHOGRAPHY; HUMAN; MALE; MULTIPLE CANCER; NEUROBLASTOMA; NEWBORN; PANCREAS CYST; PANCREAS TUMOR; PATHOLOGY; PREGNANCY; PROGNOSIS; ADRENAL BIOPSY; ADRENAL NEUROBLASTOMA; BONE MARROW BIOPSY; CANCER DIAGNOSIS; CANCER SURGERY; CHROMOSOME HIGH RESOLUTION BANDING ANALYSIS; CYSTIC PANCREATOBLASTOMA; DISEASE ASSOCIATION; DISEASE COURSE; DISOMY; DISTANT METASTASIS; ECHOGRAPHY; GENETIC ANALYSIS; HISTOPATHOLOGY; HYPOGLYCEMIA; IMMUNOCYTOCHEMISTRY; LABORATORY TEST; LIMB HEMIHYPERTROPHY; LIMB MALFORMATION; MACROGLOSSIA; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; NEUROSURGERY; PANCREAS CANCER; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RESPIRATORY DISTRESS; RISK FACTOR; SOUTHERN BLOTTING; THORAX RADIOGRAPHY; TUMOR LOCALIZATION; TUMOR VOLUME; ULTRASOUND; URINALYSIS;

ADULT; BECKWITH-WIEDEMANN SYNDROME; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INFANT, NEWBORN; MALE; NEOPLASMS, MULTIPLE PRIMARY; NEUROBLASTOMA; PANCREATIC CYST; PANCREATIC NEOPLASMS; PREGNANCY; PROGNOSIS; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY, PRENATAL;

(3 IODOBENZYL)GUANIDINE I 123;

EID: 77955886363     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3181dccd1e     Document Type: Article

References (20)

1. Cohen MM Jr. Beckwith-Wiedemann syndrome: historical, clinicopathological, and etiopathogenetic perspectives. Pediatr Dev Pathol. 2005; 8: 287-304.
2. DeBaun MR, Tucker MA. Risk of cancer during the first four years of life in children from the Beckwith-Wiedemann Syndrome Registry. J Pediatr. 1998; 132: 398-400.
3. DeBaun MR, Niemitz EL, McNeil DE, et al. Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet. 2002; 70: 604-611.
4. Muguerza R, Rodriguez A, Formigo E, et al. Pancreatoblastoma associated with incomplete Beckwith-Wiedemann syndrome: case report and review of the literature. J Pediatr Surg. 2005; 40: 1341-1344.
5. Sparago A, Cerrato F, Vernucci M, et al. Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet. 2004; 36: 958-960.
6. Cooper WN, Luharia A, Evans GA, et al. Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet. 2005; 13: 1025-1032.
7. Kim EY, Yoo SY, Kim JH, et al. Pancreatic metastasis in a child suffering with treated stage 4 neuroblastoma. Korean J Radiol. 2008; 9: 84-86.
8. Wiedemann HR. Tumours and hemihypertrophy associated with Wiedemann-Beckwith syndrome. Eur J Pediatr. 1983; 141: 129.
9. Rump P, Zeegers MP, van Essen AJ. Tumor risk in Beckwith-Wiedemann syndrome: a review and meta-analysis. Am J Med Genet A. 2005; 136: 95-104.
10. Smith AC, Choufani S, Ferreira JC, et al. Growth regulation, imprinted genes, and chromosome 11p15.5. Pediatr Res. 2007; 61(5 Pt 2): 43R-47R.
11. Lopes S, Lewis A, Hajkova P, et al. Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Hum Mol Genet. 2003; 12: 295-305.
12. Murrell A, Ito Y, Verde G, et al. Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer. PLoS One. 2008; 3: e1849.
13. Hero B, Simon T, Spitz R, et al. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J Clin Oncol. 2008; 26: 1504-1510.
14. Yoon G, Graham G, Weksberg R, et al. Neuroblastoma in a patient with the Beckwith-Wiedemann syndrome. Med Pediatr Oncol. 2002; 38: 193-199.
15. Emery LG, Shields M, Shah NR, et al. Neuroblastoma associated with Beckwith-Wiedemann syndrome. Cancer. 1983; 52: 176-179.
16. Biasotti S, Garaventa A, Villavecchia GP, et al. False-negative metaiodobenzylguanidine scintigraphy at diagnosis of neuroblastoma. Med Pediatr Oncol. 2000; 35: 153-155.
17. Défachelles AS, Martin De Lassalle E, Boutard P, et al. Pancreatoblastoma in childhood: clinical course and therapeutic management of seven patients. Med Pediatr Oncol. 2001; 37: 47-52.
18. Klimstra S, Wenig B, Adair CF, et al. Pancreatoblastoma clinicopathological study and review of the literature. Pathol. 1995; 19: 1371-1389.
19. Dall’igna P, Cecchetto G, Bisogno G, et al. Pancreatic tumors in children and adolescents: the Italian TREP project experience. Pediatr Blood Cancer. 2009.
20. Vaughan WG, Sanders DW, Grosfeld JL, et al. Favorable outcome in children with Beckwith-Wiedemann syndrome and intra-abdominal malignant tumors. J Pediatr Surg. 1995; 30: 1042-1045.