Vertebral growth modulation by electrical current in an animal model: Potential treatment for scoliosis

Journal of Pediatric Orthopaedics

Volumn 30, Issue 4, 2010, Pages 365-370

  Dodge, George R ^a,b,c   Bowen, J Richard ^a,b   Jeong, Changhoon ^a,b  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

Author keywords

Electrical stimulation; Model of scoliosis; Spinal growth modulation; Vertebral epiphysiodesis; Vertebral hemiepiphysiodesis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIRECT CURRENT; ELECTRIC CURRENT; ELECTRODE; ELECTROSTIMULATION; FEMALE; FREQUENCY MODULATION; GROWTH INHIBITION; GROWTH PLATE; HISTOLOGY; IMPLANT; NERVE ENDING; NONHUMAN; ORTHOPEDIC MANIPULATION; PRIORITY JOURNAL; RABBIT; RADIOGRAPHY; SCOLIOSIS; VERTEBRAL GROWTH MODULATION;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; FEMALE; GROWTH PLATE; RABBITS; SCOLIOSIS; SPINE;

EID: 77955880867     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/BPO.0b013e3181d8fa74     Document Type: Article

References (31)

1. Betz RR, D'Andrea LP, Mulcahey MJ, et al. Vertebral body stapling procedure for the treatment of scoliosis in the growing child. Clin Orthop Relat Res. 2005; 434: 55-60.
2. Betz RR, Kim J, D'Andrea LP, et al. An innovative technique of vertebral body stapling for the treatment of patients with adolescent idiopathic scoliosis: a feasibility, safety, and utility study. Spine. 2003; 28: S255-S265.
3. Braun JT, Akyuz E, Udall H, et al. Three-dimensional analysis of 2 fusionless scoliosis treatments: a flexible ligament tether versus a rigid-shape memory alloy staple. Spine. 2006; 31: 262-268.
4. Braun JT, Hoffman M, Akyuz E, et al. Mechanical modulation of vertebral growth in the fusionless treatment of progressive scoliosis in an experimental model. Spine. 2006; 31: 1314-1320.
5. Newton PO, Farnsworth CL, Faro FD, et al. Spinal growth modulation with an anterolateral flexible tether in an immature bovine model: disc health and motion preservation. Spine. 2008; 33: 724-733.
6. Newton PO, Faro FD, Farnsworth CL, et al. Multilevel spinal growth modulation with an anterolateral flexible tether in an immature bovine model. Spine. 2005; 30: 2608-2613.
7. Newton PO, Fricka KB, Lee SS, et al. Asymmetrical flexible tethering of spine growth in an immature bovine model. Spine. 2002; 27: 689-693.
8. Newton PO, Upasani VV, Farnsworth CL, et al. Spinal growth modulation with use of a tether in an immature porcine model. J Bone Joint Surg Am. 2008; 90: 2695-2706.
9. Smith AD, Von Lackum WH, Wylie R. An operation for stapling vertebral bodies in congenital scoliosis. J Bone Joint Surg Am. 1954; 36: 342-348.
10. Wall EJ, Bylski-Austrow DI, Kolata RJ, et al. Endoscopic mechanical spinal hemiepiphysiodesis modifies spine growth. Spine. 2005; 30: 1148-1153.
11. Zhang H, Sucato DJ. Unilateral pedicle screw epiphysiodesis of the neurocentral synchondrosis. Production of idiopathic-like scoliosis in an immature animal model. J Bone Joint Surg Am. 2008; 90: 2460-2469.
12. de Jonge T, Slullitel H, Dubousset J, et al. Late-onset spinal deformities in children treated by laminectomy and radiation therapy for malignant tumours. Eur Spine J. 2005; 14: 765-771.
13. Katzenstein HM, Kent PM, London WB, et al. Treatment and outcome of 83 children with intraspinal neuroblastoma: the Pediatric Oncology Group experience. J Clin Oncol. 2001; 19: 1047-1055.
14. Paulino AC, Fowler BZ. Risk factors for scoliosis in children with neuroblastoma. Int J Radiat Oncol Biol Phys. 2005; 61: 865-869.
15. Dodge GR, Bowen JR, Oh CW, et al. Electrical stimulation of the growth plate: a potential approach to an epiphysiodesis. Bioelectro-magnetics. 2007; 28: 463-470.
16. Dickson RA. Aetiology of idiopathic spinal deformities. Arch Dis Child. 1985; 60: 508-511.
17. Dickson RA. The aetiology of spinal deformities. Lancet. 1988; 1: 1151-1155.
18. Guo X, Chau WW, Chan YL, et al. Relative anterior spinal overgrowth in adolescent idiopathic scoliosis-result of disproportionate endochondral- membranous growth? Summary of an electronic focus group debate of the IBSE. Eur Spine J. 2005; 14: 862-873.
19. Guo X, Chau WW, Chan YL, et al. Relative anterior spinal overgrowth in adolescent idiopathic scoliosis. Results of disproportionate endochondral-membranous bone growth. J Bone Joint Surg Br. 2003; 85: 1026-1031.
20. Brighton CT, Shaman P, Heppenstall RB, et al. Tibial nonunion treated with direct current, capacitative coupling, or bone graft. Clin Orthop Relat Res. 1995; 321: 223-234.
21. Goh JC, Bose K, Kang YK, et al. Effects of electrical stimulation on the biomechanical properties of fracture healing in rabbits. Clin Orthop Relat Res. 1988; 233: 268-273.
22. Hodges SD, Jason CE, Humphreys SC. Use of electrical bone stimulation in spinal fusion. J Am Acad Orthop Surg. 2003; 11: 81-88.
23. Brighton CT, Townsend PF. Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes. J Orthop Res. 1988; 6: 552-558.
24. Bozic KJ, Glazer PA, Zurakowski D, et al. In vivo evaluation of coralline hydroxyapatite and direct current electrical stimulation in lumbar spinal fusion. Spine. 1999; 24: 2127-2133.
25. Dejardin LM, Kahanovitz N, Arnoczky SP, et al. The effect of varied electrical current densities on lumbar spinal fusions in dogs. Spine J. 2001; 1: 341-347.
26. Wang W, Wang Z, Zhang G, et al. Up-regulation of chondrocyte matrix genes and products by electric fields. Clin Orthop Relat Res. 2004; 427(suppl): S163-S173.
27. Armstrong PF, Brighton CT. Failure of the rabbit tibial growth plate to respond to the long-term application of a capacitively-coupled electrical field. J Orthop Res. 1986; 4: 446-451.
28. Okihana H, Shimomura Y. Effect of direct current on cultured growth cartilage cells in vitro. J Orthop Res. 1988; 6: 690-694.
29. Sato O, Akai M. Effect of direct-current stimulation on the growth plate. In vivo study with rabbits. Arch Orthop Trauma Surg. 1990; 109: 9-13.
30. Forgon M, Vamhidy V, Kellenyi L. Bone growth accelerated by stimulation of the epiphyseal plate with electric current. Arch Orthop Trauma Surg. 1985; 104: 121-124.
31. Fredericks DC, Smucker J, Petersen EB, et al. Effects of direct current electrical stimulation on gene expression of osteopromotive factors in a posterolateral spinal fusion model. Spine. 2007; 32: 174-181.