Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

Genes and Development

Volumn 24, Issue 16, 2010, Pages 1787-1801

  Skabkin, Maxim A ^a   Skabkina, Olga V ^a   Dhote, Vidya ^a   Komar, Anton A ^b   Hellen, Christopher U T ^a   Pestova, Tatyana V ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

HCV; Ligatin; MCT 1; Ribosomal recycling; Sindbis virus; Translation initiation

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 2; LIGATIN; MESSENGER RNA; ONCOPROTEIN; PROTEIN; PROTEIN DENR; PROTEIN MCT 1; PROTEIN SUBUNIT; TRANSFER RNA; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MONOCARBOXYLATE TRANSPORTER; VIRUS PROTEIN; VIRUS RNA;

5' UNTRANSLATED REGION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CODON; DEACYLATION; EUKARYOTE; HEPATITIS C VIRUS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RIBOSOME; TRANSCRIPTION INITIATION SITE; TRANSLATION INITIATION; ANIMAL; HEPACIVIRUS; METABOLISM; PHYSIOLOGY; PROTEIN SYNTHESIS; RABBIT; SINDBIS VIRUS; SMALL RIBOSOMAL SUBUNIT;

ANIMALS; EUKARYOTIC INITIATION FACTORS; HEPACIVIRUS; MEMBRANE PROTEINS; MONOCARBOXYLIC ACID TRANSPORTERS; PROTEIN BIOSYNTHESIS; RABBITS; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; RIBOSOMES; RNA, MESSENGER; RNA, TRANSFER; RNA, VIRAL; SINDBIS VIRUS; VIRAL PROTEINS;

EUKARYOTA; HEPATITIS C VIRUS; SINDBIS VIRUS;

EID: 77955862748     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1957510     Document Type: Article

References (48)

1. Aravind L, Koonin EV. 1999. Novel predicted RNA-binding domains associated with the translation machinery. J Mol Evol 48: 291-302.
2. Bonatti S, Sonenberg N, Shatkin AJ, Cancedda R. 1980. Restricted initiation of protein synthesis on the potentially polycistronic Sindbis virus 42 S RNA. J Biol Chem 255: 11473-11477.
3. Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V. 2001. Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science 291: 498-501.
4. Coltri PP, Guimarães BG, Granato DC, Luz JS, Teixeira EC, Oliveira CC, Zanchin NI. 2007. Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA. Biochemistry 46: 14177-14187. (Pubitemid 350250312)
5. Dai B, Zhao XF, Hagner P, Shapiro P, Mazan-Mamczarz K, Zhao S, Natkunam Y, Gartenhaus RB. 2009. Extracellular signal-regulated kinase positively regulates the oncogenic activity ofMCT-1 in diffuse large B-cell lymphoma. Cancer Res 69: 7835-7843.
6. Dallas A, Noller HF. 2001. Interaction of translation initiation factor 3 with the 30S ribosomal subunit. Mol Cell 8: 855-864.
7. de Breyne S, Yu Y, Pestova TV, Hellen CU. 2008. Factor requirements for translation initiation on the simian picornavirus internal ribosomal entry site. RNA 14: 367-380.
8. Deyo JE, Chiao PJ, Tainsky MA. 1998. drp, a novel protein expressed at high cell density but not during growth arrest. DNA Cell Biol 17: 437-447.
9. Fleischer TC, Weaver CM, McAfee KJ, Jennings JL, Link AJ. 2006. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20: 1294-1307.
10. Frolov I, Schlesinger S. 1996. Translation of Sindbis virus mRNA: Analysis of sequences downstream of the initiating AUG codon that enhance translation. J Virol 70: 1182-1190. (Pubitemid 26029040)
11. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS. 2003. Global analysis of protein expression in yeast. Nature 425: 737-741.
12. Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA. 2009. PERK-dependent regulation of IAP translation during ER stress. Oncogene 28: 910-920.
13. Hartz D, McPheeters DS, Gold L. 1989. Selection of the initiator tRNA by Escherichia coli initiation factors. Genes Dev 3: 1899-1912. (Pubitemid 20023216)
14. Hellen CU, de Breyne S. 2007. A distinct group of hepacivirus/pestivirus- like internal ribosomal entry sites in members of diverse picornavirus genera: Evidence for modular exchange of functional noncoding RNA elements by recombination. J Virol 81: 5850-5863.
15. Jackson RJ, Hellen CU, Pestova TV. 2010. The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11: 113-127.
16. Kolupaeva VG, Unbehaun A, Lomakin IB, Hellen CU, Pestova TV. 2005. Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. RNA 11: 470-486.
17. Locker N, Easton LE, Lukavsky PJ. 2007. HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly. EMBO J 26: 795-805. (Pubitemid 46253854)
18. Lomakin IB, Kolupaeva VG, Marintchev A, Wagner G, Pestova TV. 2003. Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Genes Dev 17: 2786-2797.
19. Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB. 2009. Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism. Leuk Res 33: 474-482.
20. McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljeström P. 2005. Importance of eIF2a phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell 16: 3753-3763.
21. Merrick WC, Anderson WF. 1975. Purification and characterization of homogeneous protein synthesis initiation factor M1 from rabbit reticulocytes. J Biol Chem 250: 1197-1206.
22. Milon P, Konevega AL, Gualerzi CO, Rodnina MV. 2008. Kinetic checkpoint at a late step in translation initiation. Mol Cell 30: 712-720.
23. Milon P, Carotti M, Konevega AL, Wintermeyer W, Rodnina MV, Gualerzi CO. 2010. The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. EMBO Rep 11: 312-316.
24. Miyazono K, Nishimura Y, Sawano Y, Makino T, Tanokura M. 2008. Crystal structure of hypothetical protein PH0734.1 from hyperthermophilic archaea Pyrococcus horikoshii OT3. Proteins 73: 1068-1071.
25. Montero H, Rojas M, Arias CF, López S. 2008. Rotavirus infection induces the phosphorylation of eIF2a but prevents the formation of stress granules. J Virol 82: 1496-1504.
26. Passmore LA, Schmeing TM, Maag D, Applefield DJ, Acker MG, Algire MA, Lorsch JR, Ramakrishnan V. 2007. The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell 26: 41-50.
27. Pérez-Arellano I, Gallego J, Cervera J. 2007. The PUA domain - a structural and functional overview. FEBS J 274: 4972-4984. (Pubitemid 47481183)
28. Peske F, Rodnina MV, Wintermeyer W. 2005. Sequence of steps in ribosome recycling as defined by kinetic analysis. Mol Cell 18: 403-412.
29. Pestova TV, Kolupaeva VG. 2002. The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev 16: 2906-2922.
30. Pestova TV, Shatsky IN, Hellen CU. 1996. Functional dissection of eukaryotic initiation factor 4F: The 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol Cell Biol 16: 6870-6878.
31. Pestova TV, Shatsky IN, Fletcher SP, Jackson RJ, Hellen CU. 1998. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev 12: 67-83.
32. Pestova TV, de Breyne S, Pisarev AV, Abaeva IS, Hellen CU. 2008. eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: A common role of domain II. EMBO J 27: 1060-1072.
33. Petrelli D, LaTeana A, Garofalo C, Spurio R, Pon CL, Gualerzi CO. 2001. Translation initiation factor IF3: Two domains, five functions, one mechanism? EMBO J 20: 4560-4569.
34. Pisarev AV, Kolupaeva VG, Pisareva VP, Merrick WC, Hellen CU, Pestova TV. 2006. Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. Genes Dev 20: 624-636.
35. Pisarev AV, Hellen CU, Pestova TV. 2007. Recycling of eukaryotic posttermination ribosomal complexes. Cell 131: 286-299.
36. Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV. 2010. The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell 37: 196-210.
37. Pisareva VP, Pisarev AV, Komar AA, Hellen CU, Pestova TV. 2008. Translation initiation on mammalian mRNAs with structured 5′UTRs requires DExH-box protein DHX29. Cell 135: 1237-1250.
38. Prosniak M, Dierov J, Okami K, Tilton B, Jameson B, Sawaya BE, Gartenhaus RB. 1998. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. Cancer Res 58: 4233-4237. (Pubitemid 28450016)
39. Reinert LS, Shi B, Nandi S, Mazan-Mamczarz K, Vitolo M, Bachman KE, He H, Gartenhaus RB. 2006. MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. Cancer Res 66: 8994-9001.
40. Reynolds JE, Kaminski A, Kettinen HJ, Grace K, Clarke BE, Carroll AR, Rowlands DJ, Jackson RJ. 1995. Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J 14: 6010-6020.
41. Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, et al. 2006. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i) (Met) ternary complex availability. Mol Biol Cell 17: 4632-4644.
42. Sanz MA, Castelló A, Ventoso I, Berlanga JJ, Carrasco L. 2009. Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells. PLoS ONE 4: e4772. doi: 10.1371/journal.pone. 0004772.
43. Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J. 2001. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science 291: 1959-1962.
44. Terenin IM, Dmitriev SE, Andreev DE, Shatsky IN. 2008. Eukaryotic translation initiationmachinery can operate in a bacterial-like mode without eIF2. Nat Struct Mol Biol 15: 836-841.
45. van Duijn LP, Holsappel S, Kasperaitis M, Bunschoten H, Konings D, Voorma HO. 1988. Secondary structure and expression in vivo and in vitro of messenger RNAs into which upstream AUG codons have been inserted. Eur J Biochem 172: 59-66.
46. van Steeg H, van Grinsven M, van Mansfeld F, Voorma HO, Benne R. 1981. Initiation of protein synthesis in neuroblastoma cells infected by Semliki Forest Virus. A decreased requirement of late viral mRNA for eIF-4B and cap binding protein. FEBS Lett 129: 62-66.
47. Ventoso I, Sanz MA, Molina S, Berlanga JJ, Carrasco L, Esteban M. 2006. Translational resistance of late alphavirus mRNA to eIF2α phosphorylation: A strategy to overcome the antiviral effect of protein kinase PKR. Genes Dev 20: 87-100. (Pubitemid 43042670)
48. Yu Y, Marintchev A, Kolupaeva VG, Unbehaun A, Veryasova T, Lai SC, Hong P, Wagner G, Hellen CU, Pestova TV. 2009. Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing. Nucleic Acids Res 37: 5167-5182.