Highly regioselective enzymatic synthesis of 5′-O-stearate of 1-β-D-arabinofuranosylcytosine in binary organic solvent mixtures

Applied Microbiology and Biotechnology

Volumn 88, Issue 1, 2010, Pages 57-63

  Li, Xiao Feng ^a   Zong, Min Hua ^a   Zhao, Guang Lei ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1 D arabinofuranosylcytosine; Binary organic solvents; Lipases; Vinyl stearate

Indexed keywords

ACYLATION REACTIONS; ACYLATIONS; ANTI-TUMOR ACTIVITIES; BINARY ORGANIC SOLVENTS; CANDIDA ANTARCTICA LIPASE B; CARBON-13; CATALYTIC ACTIVITY; COMPARATIVE STUDIES; COSOLVENTS; ENZYMATIC SYNTHESIS; HYDROLASES; HYDROPHOBIC SOLVENT; MOLAR RATIO; NOVOZYM435; ORGANIC SOLVENT SYSTEM; REACTION CONDITIONS; REACTION TEMPERATURE; REGIO-SELECTIVE; REGIOSELECTIVE ACYLATION; SOLVENT MIXTURES; SUBSTRATE CONVERSION; VINYL STEARATE; WATER ACTIVITY;

ACYLATION; BINARY MIXTURES; CATALYST ACTIVITY; HEXANE; IONIC LIQUIDS; LIPASES; ORGANIC SOLVENTS; REACTION RATES; SYNTHESIS (CHEMICAL); WATER CONTENT;

REGIOSELECTIVITY;

5 'O STEARATE 1 BETA DEXTRO ARABINOFURANOSYLCYTOSINE; CYTARABINE; CYTARABINE DERIVATIVE; HEXANE; LIPASE B; ORGANIC SOLVENT; PYRIDINE; UNCLASSIFIED DRUG;

CATALYSIS; COMPARATIVE STUDY; ENZYME ACTIVITY; HYDROPHOBICITY; IMMOBILIZATION; SOLVENT; SUBSTRATE; YEAST;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; COMPARATIVE STUDY; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME STABILITY; ENZYME SYNTHESIS; NONHUMAN; TEMPERATURE;

ANTINEOPLASTIC AGENTS; CANDIDA; CYTARABINE; ENZYMES, IMMOBILIZED; HEXANES; HYDROLASES; PYRIDINES; SOLVENTS; STEARATES; TEMPERATURE;

ARA; CANDIDA ANTARCTICA;

EID: 77955852572     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2705-1     Document Type: Article

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