Beyond Neuroprotection to Brain Repair: Exploring the Next Frontier in Clinical Neuroscience to Expand the Therapeutic Window for Stroke

Translational Stroke Research

Volumn 1, Issue 2, 2010, Pages 71-73

  Ratan, Rajiv R ^a  

^a Burke Cornell Medical Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISABILITY; EDITORIAL; HUMAN; NERVE REGENERATION; NEUROPROTECTION; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; STROKE;

EID: 77955850633     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-010-0024-6     Document Type: Editorial

References (14)

1. Hong KS, Saver JL. Years of disability-adjusted life gained as a result of thrombolytic therapy for acute ischemic stroke. Stroke. 2010; 41(3): 471-7. Epub 2010 Feb 4.
2. Mahnken JD, Mayo MS, Nudo RJ. A decision algorithm for translating preclinical trial results to enhance recovery after stroke. J Biopharm Stat. 2009; 19(1): 204-16.
3. Carmichael ST. Translating the frontiers of brain repair to treatments: starting not to break the rules. Neurobiol Dis. 2010; 37(2): 237-42. Epub 2009 Sep 18.
4. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Neurobiol Dis. 2010; 37(2): 237-42. Epub 2009 Sep 18.
5. Xiong Y, Mahmood A, Chopp M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs. 2010; 11(3): 298-308.
6. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009; 276(17): 4644-52. Epub 2009 Jul 31.
7. Kleim JA, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R, et al. BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat Neurosci. 2006; 9(6): 735-7. Epub 2006 May 7.
8. Fang PC, Barbay S, Plautz EJ, Hoover E, Strittmatter SM, Nudo RJ. Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats. Stroke. 2010; 41(3): 544-9. Epub 2010 Jan 14.
9. Prusky GT, Silver BD, Tschetter WW, Alam NM, Douglas RM. Experience-dependent plasticity from eye opening enables lasting, visual cortex-dependent enhancement of motion vision. J Neurosci. 2008; 28(39): 9817-27.
10. Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, et al. A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci. 2010; 30(2): 739-48.
11. Tillerson JL, Cohen AD, Caudle WM, Zigmond MJ, Schallert T, Miller GW. Forced nonuse in unilateral parkinsonian rats exacerbates injury. J Neurosci. 2002; 22(15): 6790-9.
12. Cai D, Deng K, Mellado W, Lee J, Ratan RR, Filbin MT. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 2002; 35(4): 711-9.
13. Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, et al. Harnessing hypoxic adaptation to prevent, treat, and repair stroke. J Mol Med. 2007; 85(12): 1331-8. Epub 2007 Nov 28.
14. Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, et al. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc Natl Acad Sci U S A. 2009; 106(46): 19599-604. Epub 2009 Nov 2.