Direct and indirect pathways in levodopa-induced dyskinesia: A more complex matter than a network imbalance

Movement Disorders

Volumn 25, Issue 11, 2010, Pages 1527-1529

  Ghiglieri, Veronica ^a   Picconi, Barbara ^a   Calabresi, Paolo ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; LEVODOPA;

BASAL GANGLION; DYSKINESIA; EDITORIAL; HUMAN; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MOTOR CONTROL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; ANTIPARKINSON AGENTS; DYSKINESIA, DRUG-INDUCED; HUMANS; LEVODOPA; NEURAL PATHWAYS; PARKINSON DISEASE;

EID: 77955833738     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23244     Document Type: Editorial

References (22)

1. Heimer G, Rivlin-Etzion M, Bar-Gad I, Goldberg JA, Haber SN, Bergman H. Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl- 1,2,3,6-tetra-hydropyridine primate model of Parkinsonism. J Neurosci 2006;26:8101-8114.
2. Leblois A, Boraud T, Meissner W, Bergman H, Hansel D. Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia. J Neurosci 2006;26:3567-3583.
3. Obeso JA, Rodriguez-Oroz MC, Rodriguez M, et al. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci 2000;23(10 Suppl):S8-S19.
4. Calabresi P, Picconi B, Tozzi A, Di Filippo M. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends Neurosci 2007;30:211-219.
5. Calabresi P, Maj R, Pisani A, Mercuri NB, Bernardi G. Longterm synaptic depression in the striatum: physiological and pharmacological characterization. J Neurosci 1992;12:4224-4233.
6. Goldberg MS, Pisani A, Haburcak M, et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 2005;45:489-496.
7. Picconi B, Centonze D, Hakansson K, et al. Loss of bidirectional striatal synaptic plasticity in L-dopa-induced dyskinesia. Nat Neurosci 2003;6:501-506.
8. Picconi B, Paille V, Ghiglieri V, et al. L-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation. Neurobiol Dis 2008;29:327-335.
9. Morgante F, Espay AJ, Gunraj C, Lang AE, Chen R. Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias. Brain 2006;129:1059-1069.
10. Prescott IA, Dostrovsky JO, Moro E, Hodaie M, Lozano AM, Hutchison WD. Levodopa enhances synaptic plasticity in the substantia nigra pars reticulata of Parkinson's disease patients. Brain 2009;132:309-318.
11. Calabresi P, Di Filippo M, Ghiglieri V, Picconi B. Molecular mechanisms underlying levodopa-induced dyskinesia. Mov Disord 2008;23(Suppl 3):S570-S579.
12. Galvan A, Wichmann T. Pathophysiology of parkinsonism. Clin Neurophysiol 2008;119:1459-1474.
13. Jenner P. Molecular mechanisms of L-dopa-induced dyskinesia. Nat Rev Neurosci 2008;9:665-677.
14. Kawaguchi Y, Wilson CJ, Augood SJ, Emson PC. Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci 1995;18:527-535.
15. Centonze D, Gubellini P, Bernardi G, Calabresi P. Permissive role of interneurons in corticostriatal synaptic plasticity. Brain Res Brain Res Rev 1999;31:1-5.
16. Centonze D, Gubellini P, Pisani A, Bernardi G, Calabresi P. Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity. Rev Neurosci 2003;14: 207-216.
17. Charpier S, Deniau JM. In vivo activity-dependent plasticity at cortico-striatal connections: evidence for physiological long-term potentiation. Proc Natl Acad Sci USA 1997;94:7036-7040.
18. Lovinger DM, Tyler EC, Merritt A. Short- and long-term synaptic depression in rat neostriatum. J Neurophysiol 1993;70:1937-1949.
19. Partridge JG, Tang KC, Lovinger DM. Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum. J Neurophysiol 2000;84:1422-1429.
20. Walsh JP. Depression of excitatory synaptic input in rat striatal neurons. Brain Res 1993;608:123-128.
21. Mahon S, Deniau JM, Charpier S. Corticostriatal plasticity: life after the depression. Trends Neurosci 2004;27:460-467.
22. Reynolds JN, Wickens JR. Substantia nigra dopamine regulates synaptic plasticity and membrane potential fluctuations in the rat neostriatum, in vivo. Neuroscience 2000;99:199-203.