Folic acid supplementation may cure hot flushes in postmenopausal women: A prospective cohort study

Gynecological Endocrinology

Volumn 26, Issue 9, 2010, Pages 658-662

  Gaweesh, Sherief S ^a   Abdel Gawad, Mohamed M M ^a   Nagaty, Ahmed M ^a   Ewies, Ayman A A ^b  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b IPSWICH HOSPITAL NHS TRUST   (United Kingdom)

Author keywords

3 methoxy 4 hydroxy phenyl glycol; Folic acid; hot flushes; norepinephrine

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; FOLIC ACID; NORADRENALIN; PLACEBO; SEROTONIN;

ADULT; ARTICLE; BANANA; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; FEMALE; HOT FLUSH; HUMAN; METABOLITE; PATHOPHYSIOLOGY; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEROTONIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WALNUT;

COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HOT FLASHES; HUMANS; MIDDLE AGED; PLACEBOS; POSTMENOPAUSE; PROSPECTIVE STUDIES;

EID: 77955826089     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513591003686288     Document Type: Article

References (28)

1. Freedman RR. Hot flashes: behavioral treatments, mechanisms, and relation to sleep. Am J Med 2005;118 (Suppl 12B):124-130.
2. Scott JA, Da Camara CC, Early JE. Raloxifene: a selective estrogen receptor modulator. Am Fam Physician 1999;60: 1131-1139.
3. Berendsen H. The role of serotonin in hot flushes. Maturitas 2000;36:155-164
4. Alfhaily F, Ewies AA. Acupuncture in managing menopausal symptoms: hope or mirage? Climacteric 2007;10:371-380.
5. Freedman RR, Woodward S, Sabharwal SC. Alpha 2-adrenergic mechanism in menopausal hot flushes. Obstet Gynecol 1990;76:573-578.
6. Freedman RR. Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes. Fertil Steril 1998;70:332-337.
7. Casper RF, Yen SS. Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clin Endocrinol (Oxf) 1985;22:293-312.
8. Feldman BM, Voda A, Gronseth E. The prevalence of hot flash and associated variables among perimenopausal women. Res Nurs Health 1985;8:261-268.
9. Raible M, Kueck B, Alkan S. Red blood cell disorders. In: McClatchey K, McClatchey KS, editors. Clinical Laboratory Medicine. 2nd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2002. pp 830-865.
10. Drake V. Folic acid: Linus Pauling Institute, Oregon State University. http://lpi.oregonstate.edu/infocenter/vitamins/fa. Last accessed December 2008.
11. IPCS-INCHEM. Folic acid. http://www.inchem.org/documents/pims/pharm/ folicaci.htm. Last accessed January 2010.
12. Gover P. Biochemical aspects of anaemia. In: Marshall W, Bangert S, Marshall W, Bangert SS, editors. Clinical biochemistry-metabolic and clinical aspects. 2nd ed. London: Churchill Livingstone Elsevier; 2008. pp 538-557.
13. Botez MI, Young SN, Bachevalier J, Gauthier S. Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. Nature 1979;278:182-183.
14. Manzoor M, Runcie J. Folate-responsive neuropathy: report of 10 cases. Br Med J 1976;1:1176-1178.
15. Brocardo PS, Budni J, Kaster MP, Santos AR, Rodrigues AL. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology 2008;54: 464-473.
16. Kema IP, Schellings AM, Meiborg G, Hoppenbrouwers CJ, Muskiet FA. Influence of a serotonin-and dopamine-rich diet on platelet serotonin content and urinary excretion of biogenic amines and their metabolites. Clin Chem 1992;38: 1730-1736.
17. Hariharan M, VanNoord T, Cameron OG, Curtis GC, Ostrow DG. Free 3-methoxy-4-hydroxyphenylglycol determined in plasma by liquid chromatography with coulometric detection. Clin Chem 1989;35:202-205.
18. Delaunay L, Herail T, Sessler DI, Lienhart A, Bonnet F. Clonidine increases the sweating threshold, but does not reduce the gain of sweating. Anesth Analg 1996;83:844-848.
19. Delaunay L, Bonnet F, Liu N, Beydon L, Catoire P, Sessler DI. Clonidine comparably decreases the thermoregulatory thresholds for vasoconstriction and shivering in humans. Anesthesiology 1993;79:470-474.
20. Bottiglieri T, Laundy M, Crellin R, Toone BK, Carney MW, Reynolds EH. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000;69:228-232.
21. Bottiglieri T, Hyland K, Laundy M, Godfrey P, Carney MW, Toone BK, Reynolds EH. Folate deficiency, biopterin and monoamine metabolism in depression. Psychol Med 1992;22: 871-876.
22. Lucock MD, Green M, Levene MI. Methylfolate modulates potassium evoked neuro-secretion: evidence for a role at the pteridine cofactor level of tyrosine 3-hydroxylase. Neurochem Res 1995;20:727-736.
23. Bethea CL, Pecins-Thompson M, Schutzer WE, Gundlah C, Lu ZN. Ovarian steroids and serotonin neural function. Mol Neurobiol 1998;18:87-123.
24. Blum I, Vered Y, Lifshitz A, Harel D, Blum M, Nordenberg Y, Harsat A, Sulkes J, Gabbay U, Graff E. The effect of estrogen replacement therapy on plasma serotonin and catecholamines of postmenopausal women. Isr J Med Sci 1996;32:1158-1162.
25. Lippert TH, Filshie M, Muck AO, Seeger H, Zwirner M. Serotonin metabolite excretion after postmenopausal estradiol therapy. Maturitas 1996;24:37-41. (Pubitemid 26180102)
26. Mann JJ, Stanley M, McBride PA, McEwen BS. Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 1986;43:954-959.
27. Korevaar WC, Geyer MA, Knapp S, Hsu LL, Mandell AJ. Regional distribution of 5-methyltetrahydrofolic acid in brain. Nat New Biol 1973;245:244-245.
28. Botez MI, Young SN, Bachevalier J, Gauthier S. Effect of folic acid and vitamin B12 deficiencies on 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Ann Neurol 1982;12:479-484.