Misoprostol dose and route after mifepristone for early medical abortion: A randomised controlled noninferiority trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 117, Issue 10, 2010, Pages 1186-1196

  Von Hertzen, H ^a   Huong, N T M ^a   Piaggio, G ^a   Bayalag, M ^b   Cabezas, E ^c   Fang, A H ^d   Gemzell Danielsson, K ^e   Hinh, N D ^f   Mittal, S ^g   Ng, E H Y ^h   Chaturachinda, K ⁱ   Pinter, B ^j   Puscasiu, L ^k   Savardekar, L ^l   Shenoy, S ^m   Khomassuridge, A ⁿ   Tuyet, H T D ^o   Velasco, A ^p   Peregoudov, A ^a  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

^b State Research Centre on Maternal and Child Heath   (Mongolia)

^c Eusebio Hernandez   (Cuba)

^d School of Medicine   (China)

^e KAROLINSKA INSTITUTE   (Sweden)

^f National Hospital of Obstetrics and Gynecology   (Viet Nam)

^g ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^h QUEEN MARY HOSPITAL   (Hong Kong)

ⁱ MAHIDOL UNIVERSITY   (Thailand)

^j UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^k Center of Public Health   (Romania)

^l NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

^m GOVERNMENT MEDICAL COLLEGE   (India)

ⁿ Zhordania Institute on Human Reproduction   (Georgia)

^o Tu du Hospital   (Viet Nam)

^p HOSPITAL CLINICOQUIRÚRGICO HERMANOS AMEIJEIRAS   (Cuba)

more..

Author keywords

Factorial design; medical abortion; mifepristone; misoprostol dose and route

Indexed keywords

MIFEPRISTONE; MISOPROSTOL; PLACEBO; ABORTIVE AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; GESTATIONAL AGE; HUMAN; MEDICAL ABORTION; NORMAL HUMAN; OUTCOME ASSESSMENT; PREGNANT WOMAN; PRIORITY JOURNAL; CLINICAL TRIAL; DRUG COMBINATION; FIRST TRIMESTER PREGNANCY; INDUCED ABORTION; INTRAVAGINAL DRUG ADMINISTRATION; MULTICENTER STUDY; PATIENT SATISFACTION; PREGNANCY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; SUBLINGUAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTIFACIENT AGENTS, STEROIDAL; ABORTION, INDUCED; ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, SUBLINGUAL; ADULT; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MIFEPRISTONE; MISOPROSTOL; PATIENT SATISFACTION; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TREATMENT OUTCOME;

EID: 77955821321     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2010.02636.x     Document Type: Article

References (13)

1. World Health Organization (WHO). Safe Abortion: Technical And Policy Guidance For Health Systems.
2. World Health Organization Task Force on Post-Ovulatory Methods for Fertility Regulation. Comparison of two doses of mifepristone in combination with misoprostol for early medical abortion: a randomized trial. BJOG 2000 107 : 524 30.
3. el-Refaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU486) and oral or vaginal misoprostol. N Engl J Med 1995 332 : 983 7.
4. Tang OS, Chan CC, Ng EH, Lee SW, Ho PC. A prospective, randomised, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misoprostol for medical abortion of less than 9 weeks gestation. Hum Reprod 2003 18 : 2315 8.
5. Winikoff B, Dzuba IG, Creinin MD, Crowden WA, Goldberg AB, Gonzales J, et al. Two distinct routes of misoprostol in mifepristone medical abortion. Obstet Gynecol 2008 112 : 1303 10.
6. Hamoda H, Ashok PW, Dow J, Flett GM, Templeton A. A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation. Contraception 2003 68 : 335 8.
7. Raghavan S, Comendant R, Digol I, Ungureanu S, Friptu V, Bracken H, et al. Two-pill regimens of misoprostol after mifepristone medical abortion through 63 days' gestational age: a randomized controlled trial of sublingual and oral misoprostol. Contraception 2009 79 : 84 90.
8. von Hertzen H, Piaggio G, Wojdyla D, Marions L, Huong NTM, Tang OS, et al. Two mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomized factorial controlled equivalence trial. BJOG 2009 116 : 381 9.
9. von Hertzen H, Piaggio G, Marions L. Comparison of two doses and two routes of administration of misoprostol after pre-treatment with mifepristone for early pregnancy termination. Reprod Health 2008 5 : 2.
10. von Hertzen H, Honkanen H, Piaggio G, Bartfai G, Erdenetungalag R, Gemzell-Danielsson K, et al. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy. BJOG 2003 110 : 808 18.
11. Fjerstad M, Trussel J, Sivin I, Lichtenberg ES, Cullins V. Rates of serious infection after changes in regimens for medical abortion. N Engl J Med 2009 361 : 145 51.
12. von Hertzen H, Piaggio G, Huong NT, Arustamyan K, Cabezas E, Gomez M, et al. Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial. Lancet 2007 369 : 1938 46.
13. Aronsson A, Bygdeman M, Gemzell-Danielsson K. Effects of misoprostol on uterine contractility following different routes of administration. Hum Reprod 2004 19 : 81 4.