A PAT study of an industrial catalytic hydrogenation of an active pharmaceutical ingredient

Computer Aided Chemical Engineering

Volumn 18, Issue C, 2004, Pages 775-780

  Rodrigues, Licínia O ^a   Lopes, João A ^b   Cardoso, Joaquim P ^a   Menezes, José C ^b  

^a AtralCipan   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

multivariate modelling; near infrared; NIR; PAT; pharmaceutical production; PLS; process analytical technologies

Indexed keywords

EID: 77955815957     PISSN: 15707946     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1570-7946(04)80195-0     Document Type: Article

References (5)

1. May, Frankfurt, Germany. ACHEMA. Pharmaceutical Production Technology (PAT I & II) Sessions (2003)
2. Dyson R., Hazenkamp M., Kaufmann K., Maeder M., Studer M., and Zilian A. Modern Tools for Reaction Monitoring: hard and soft analysis of 'non-ideal' spectra from in situ monitoring. J. Chemometrics 14 (2000) 737
3. (Draft Guideline). FDA. PAT - A Framework for Innovative Pharmaceutical Manufacturing and Quality Assurance (2003). http://www.fda.gov/cder/OPS/PAT.htm
4. Naes T., Isaksson T., Fearn T., and Davies T. A User Friendly Guide to Multivariate Calibration and Classification (2002), NIR Publications, NY
5. Rodrigues L., Zilian A., Lopes J., Cardoso J., and Menezes J. Monitoring an Industrial Catalytic Hydrogenation Reaction with an FT-NIR Transflectance Probe, P.6.2. 11th Int. Conf. Near Infrared Spectroscopy. 11 April, Cordoba, Spain (2003)