SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL)

British Journal of Haematology

Volumn 150, Issue 5, 2010, Pages 633-636

  Philippen, Angela ^a   Diener, Susanne ^a   Zenz, Thorsten ^a   Döhner, Hartmut ^a   Stilgenbauer, Stephan ^a   Mertens, Daniel ^a,b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

BCR signalling; CLL; mutations; SYK; SYK inhibitors

Indexed keywords

CD19 ANTIGEN; DNA; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; TUMOR PROTEIN;

B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; DNA METHYLATION; EPIGENETICS; EXON; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; LETTER; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; GENETICS; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; NEOPLASM PROTEINS; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-TYROSINE KINASES;

EID: 77955811113     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08244.x     Document Type: Letter

References (10)

1. Brown, J.R., Levine, R.L., Thompson, C., Basile, G., Gilliland, D.G. Freedman, A.S. (2008) Systematic genomic screen for tyrosine kinase mutations in CLL. Leukemia, 22, 1966 1969.
2. Buchner, M., Fuchs, S., Prinz, G., Pfeifer, D., Bartholomé, K., Burger, M., Chevalier, N., Vallat, L., Timmer, J., Gribben, J.G., Jumaa, H., Veelken, H., Dierks, C. Zirlik, K. (2009) Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Research, 69, 5424 5432.
3. Caligaris-Cappio, F. Hamblin, T.J. (1999) B-Cell chronic lymphocytic leukemia: a bird of a different feather. Journal of Clinical Oncology, 17, 399 408.
4. Chan, A.C., Kadlecek, T.A., Elder, M.E., Filipovich, A.H., Kuo, W.L., Iwashima, M., Parslow, T.G. Weiss, A. (1994) ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science, 264, 1599 1601.
5. Chiorazzi, N., Rai, K.R. Ferrarini, M. (2005) Chronic lymphocytic leukemia. New England Journal of Medicine, 352, 804 815.
6. Damle, R.N., Wasil, T., Fais, F., Ghiotto, F., Valetto, A., Allen, S.L., Buchbinder, A., Budman, D., Dittmar, K., Kolitz, J., Lichtman, S.M., Schulman, P., Vinciguerra, V.P., Rai, K.R., Ferrarini, M. Chiorazzi, N. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood, 94, 1840 1847.
7. Döhner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Kröber, A., Bullinger, L., Döhner, K., Bentz, M. Lichter, P. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. New England Journal of Medicine, 343, 1910 1916. (Pubitemid 32064784)
8. Friedberg, J.W., Sharman, J., Sweetenham, J., Johnston, P.B., Vose, J.M., Lacasce, A., Schaefer-Cutillo, J., De Vos, S., Sinha, R., Leonard, J.P., Cripe, L.D., Gregory, S.A., Sterba, M.P., Lowe, A.M., Levy, R. Shipp, M.A. (2010) Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood, 115, 2578 2585.
9. Ghia, P., Stamatopoulos, K., Belessi, C., Moreno, C., Stella, S., Guida, G., Michel, A., Crespo, M., Laoutaris, N., Montserrat, E., Anagnostopoulos, A., Dighiero, G., Fassas, A., Caligaris-Cappio, F. Davi, F. (2005) Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood, 105, 1678 1685.
10. Kulathu, Y., Hobeika, E., Turchinovich, G. Reth, M.T. (2008) The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO Journal, 27, 1333 1344.