Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3

Journal of Biomedical Science

Volumn 17, Issue 1, 2010, Pages

  Salaemae, Wanisa ^a   Junaid, Muhammad ^a,b   Angsuthanasombat, Chanan ^a   Katzenmeier, Gerd ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANTIVIRUS AGENT; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; MULTIPROTEIN COMPLEX; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEASE, DENGUE VIRUS; SERINE PROTEINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME RELEASE; ENZYME SUBSTRATE; ESCHERICHIA COLI; FLUORESCENCE ANALYSIS; FLUOROMETRY; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WEST NILE FLAVIVIRUS; WILD TYPE; COMPARATIVE STUDY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METHODOLOGY; PROTEIN CONFORMATION;

DENGUE VIRUS;

CATALYTIC DOMAIN; DENGUE VIRUS; FLUOROMETRY; KINETICS; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77955802960     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-17-68     Document Type: Article

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