Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning

Psychopharmacology

Volumn 212, Issue 1, 2010, Pages 45-57

  Li, Ming ^a   Sun, Tao ^a,b   Zhang, Chen ^a,c   Hu, Gang ^b  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

2,5 dimethoxy 4 iodo amphetamine; Clozapine; Conditioned avoidance response; Haloperidol; Olanzapine; Quinpirole; Repeated antipsychotic treatment; Sensitization; Tolerance

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; QUINPIROLE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONDITIONING; CONTROLLED STUDY; ESCAPE BEHAVIOR; FOOTSHOCK; HABITUATION; INHIBITION KINETICS; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RAT; RECEPTOR BLOCKING; STIMULUS RESPONSE; TRAINING;

ANIMALS; ANTIPSYCHOTIC AGENTS; AVOIDANCE LEARNING; BENZODIAZEPINES; CLOZAPINE; DOPAMINE ANTAGONISTS; DRUG ADMINISTRATION SCHEDULE; HALOPERIDOL; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; SEROTONIN ANTAGONISTS;

EID: 77955775096     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1925-5     Document Type: Article

References (58)

1. D Amato MA Stasi F Borsini P Nencini 2008 Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia Psychopharmacology (Berl) 200 157 165 10.1007/s00213-008-1229-1 1:CAS:528:DC%2BD1cXhtFOjsLfK
2. J Arnt 1982 Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade Acta Pharmacol Toxicol (Copenh) 51 321 329 1:CAS:528:DyaL3sXmsFehug%3D%3D
3. JB Atkins J Chlan-Fourney HE Nye N Hiroi WA Carlezon Jr EJ Nestler 1999 Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs Synapse 33 118 128 10.1002/(SICI)1098- 2396(199908)33:2<118::AID-SYN2>3.0.CO;2-L 1:CAS:528:DyaK1MXksFKqtL0%3D 10400890 (Pubitemid 29319289)
4. F Benaliouad S Kapur PP Rompre 2007 Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward Neuropsychopharmacology 32 551 561 10.1038/sj.npp.1301136 1:CAS:528:DC%2BD2sXhslWhu7k%3D 16794561
5. RC Bolles 1970 Species-specific defense reactions and avoidance learning Psychol Rev 77 32 48 10.1037/h0028589
6. S Bonaccorso HY Meltzer Z Li J Dai AR Alboszta J Ichikawa 2002 SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens Neuropsychopharmacology 27 430 441 10.1016/S0893-133X(02)00311-1 1:CAS:528:DC%2BD38XmvVWqs7g%3D 12225700 (Pubitemid 35253790)
7. JL Browning T Patel PC Brandt KA Young LA Holcomb PB Hicks 2005 Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions Biol Psychiatry 57 617 623 10.1016/j.biopsych.2004.12.002 1:CAS:528:DC%2BD2MXisVWqs7g%3D 15780848 (Pubitemid 40409701)
8. PR Buckland U D'Souza NA Maher P McGuffin 1997 The effects of antipsychotic drugs on the mRNA levels of serotonin 5HT2A and 5HT2C receptors Brain Res Mol Brain Res 48 45 52 10.1016/S0169-328X(97)00076-4 1:CAS:528:DyaK2sXkt1SltL4%3D 9379848 (Pubitemid 27298127)
9. SB Caine MA Geyer NR Swerdlow 1995 Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat Neuropsychopharmacology 12 139 145 10.1016/0893-133X(94)00071-7 1:CAS:528:DyaK2MXlsVektLk%3D 7779242
10. JA Davies PH Redfern 1974 The interaction of dopamine-antagonists and amantadine hydrochloride on the acquisition of the conditioned avoidance response in rats Neuropharmacology 13 941 948 10.1016/0028-3908(74)90085-9 1:CAS:528:DyaE2MXotVGktA%3D%3D 4437729
11. M Dragunow GS Robertson RL Faull HA Robertson K Jansen 1990 D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons Neuroscience 37 287 294 10.1016/0306-4522(90)90399-O 1:CAS:528:DyaK3MXkvFA%3D 1966822 (Pubitemid 20268182)
12. PJ Elliott DM Walsh SP Close GA Higgins AG Hayes 1990 Behavioural effects of serotonin agonists and antagonists in the rat and marmoset Neuropharmacology 29 949 956 10.1016/0028-3908(90)90146-I 1:CAS:528:DyaK3MXjsFymug%3D%3D 2123971 (Pubitemid 20347441)
13. AJ Goudie JC Cole HR Sumnall 2007 Olanzapine and JL13 induce cross-tolerance to the clozapine discriminative stimulus in rats Behav Pharmacol 18 9 17 10.1097/FBP.0b013e328014138d 1:CAS:528:DC%2BD2sXjvFKltw%3D%3D 17218793 (Pubitemid 46103279)
14. AJ Goudie GD Cooper JC Cole HR Sumnall 2007 Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats J Psychopharmacol 21 179 190 10.1177/0269881107067076 1:CAS:528: DC%2BD2sXkt1Wksbw%3D 17329298 (Pubitemid 46280470)
15. MI Granoff CR Ashby Jr 1998 The effect of the repeated administration of the compound 3, 4-methylenedioxymethamphetamine on the response of rats to the 5-HT2A, C receptor agonist (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Neuropsychobiology 37 36 40 10.1159/000026474 1:CAS:528: DyaK1cXkvF2hug%3D%3D 9438270
16. SM Grauer R Graf R Navarra A Sung SF Logue G Stack C Huselton Z Liu TA Comery KL Marquis S Rosenzweig-Lipson 2009 WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics Psychopharmacology (Berl) 204 37 48 10.1007/s00213-008-1433-z 1:CAS:528:DC%2BD1cXhsFartbrI
17. AL Halberstadt I van der Heijden MA Ruderman VB Risbrough JA Gingrich MA Geyer SB Powell 2009 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice Neuropsychopharmacology 34 1958 1967 10.1038/npp.2009.29 1:CAS:528:DC%2BD1MXnsFSju70%3D 19322172
18. MF Hawkins SM Uzelac JK Hearn AA Baumeister 2008 Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat Pharmacol Biochem Behav 90 632 639 10.1016/j.pbb.2008.05.006 1:CAS:528:DC%2BD1cXhtVClurnK 18572227
19. V Hillegaart A Estival S Ahlenius 1996 Evidence for specific involvement of 5-HT1A and 5-HT2A/C receptors in the expression of patterns of spontaneous motor activity of the rat Eur J Pharmacol 295 155 161 10.1016/0014-2999(95) 00666-4 1:CAS:528:DyaK28XjtVaqsg%3D%3D 8720579 (Pubitemid 26027135)
20. J Ichikawa J Dai HY Meltzer 2001 DOI, a 5-HT2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release Brain Res 907 151 155 10.1016/S0006-8993(01)02596-3 1:CAS:528:DC%2BD3MXks1Onurc%3D 11430898 (Pubitemid 32595524)
21. S Kapur P Seeman 2001 Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: a new hypothesis Am J Psychiatry 158 360 369 10.1176/appi.ajp.158.3.360 1:STN:280: DC%2BD3M7pslSltg%3D%3D 11229973 (Pubitemid 32205190)
22. S Kapur ML Wadenberg G Remington 2000 Are animal studies of antipsychotics appropriately dosed? Lessons from the bedside to the bench Can J Psychiatry 45 241 246 1:STN:280:DC%2BD3c3kt1WmsA%3D%3D 10779880
23. S Kapur SC VanderSpek BA Brownlee JN Nobrega 2003 Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy J Pharmacol Exp Ther 305 625 631 10.1124/jpet.102.046987 1:CAS:528:DC%2BD3sXjt12murk%3D 12606608 (Pubitemid 36459179)
24. K Krebs-Thomson MA Geyer 1996 The role of 5-HT(1A) receptors in the locomotor-suppressant effects of LSD: WAY-100635 studies of 8-OH-DPAT, DOI and LSD in rats Behav Pharmacol 7 551 559 1:CAS:528:DyaK2sXmsF2qsA%3D%3D 11224452
25. Levis DJ, Brewer KE (2001) The neurotic paradox: attempts by two-factor fear theory and alternative avoidance models to resolve the issues associated with sustained avoidance responding in extinction. In: Mowrer RR, Klein SB (eds) Handbook of contemporary learning theories. Lawrence Erlbaum, Mahwah, pp 561-597
26. M Li P Davidson R Budin S Kapur AS Fleming 2004 Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats Schizophr Res 70 69 80 10.1016/j.schres.2003.09.013 15246466 (Pubitemid 38916630)
27. M Li PJ Fletcher S Kapur 2007 Time course of the antipsychotic effect and the underlying behavioral mechanisms Neuropsychopharmacology 32 263 272 10.1038/sj.npp.1301110 1:CAS:528:DC%2BD2sXltlSjsg%3D%3D 16738541 (Pubitemid 46106933)
28. M Li W He A Mead 2009 An investigation of the behavioral mechanisms of antipsychotic action using a drug-drug conditioning paradigm Behav Pharmacol 20 184 194 10.1097/FBP.0b013e32832a8f66 1:CAS:528:DC%2BD1MXktFCkurw%3D 19322074
29. M Li W He A Mead 2009 Olanzapine and risperidone disrupt conditioned avoidance responding in phencyclidine-pretreated or amphetamine-pretreated rats by selectively weakening motivational salience of conditioned stimulus Beh'av Pharmacol 20 84 98 10.1097/FBP.0b013e3283243008
30. A Mead M Li 2009 Avoidance-suppressing effect of antipsychotic drugs is progressively potentiated after repeated administration: an interoceptive drug state mechanism J Psychopharmacol 24 1045 1053 10.1177/0269881109102546 19329544
31. A Mead M Li S Kapur 2008 Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide Pharmacol Biochem Behav 90 551 562 10.1016/j.pbb.2008.04. 014 1:CAS:528:DC%2BD1cXhtVClurjJ 18547622
32. Meltzer H (2002) Mechanisms of action of atypical antipsychotic drugs. In: Davis KL, Charney D, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology the fifth generation of progress: an official publication of the American College of Neuropsychopharmacology. Lippincott Williams & Wilkins, Philadelphia
33. HY Meltzer S Matsubara JC Lee 1989 The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs Psychopharmacol Bull 25 390 392 1:CAS:528:DyaK3cXhsFWmu7Y%3D 2576319
34. HY Meltzer Z Li Y Kaneda J Ichikawa 2003 Serotonin receptors: their key role in drugs to treat schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 27 1159 1172 10.1016/j.pnpbp.2003.09.010 1:CAS:528:DC%2BD3sXpt1SgtLg%3D 14642974 (Pubitemid 37464960)
35. S Miyamoto GE Duncan CE Marx JA Lieberman 2005 Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs Mol Psychiatry 10 79 104 10.1038/sj.mp.4001556 1:CAS:528:DC%2BD2cXhtFeisL3M 15289815 (Pubitemid 40139590)
36. T Moran-Gates L Gan YS Park K Zhang RJ Baldessarini FI Tarazi 2006 Repeated antipsychotic drug exposure in developing rats: dopamine receptor effects Synapse 59 92 100 10.1002/syn.20220 1:CAS:528:DC%2BD28XjvFKltw%3D%3D 16270300 (Pubitemid 43054378)
37. I Ninan SK Kulkarni 1999 Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics Meth Find Exp Clin Pharmacol 21 603 608 1:CAS:528:DC%2BD3cXnsVKmsA%3D%3D
38. CK Olsen LT Brennum M Kreilgaard 2008 Using pharmacokinetic- pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics Eur J Pharmacol 584 318 327 10.1016/j.ejphar. 2008.02.005 1:CAS:528:DC%2BD1cXksVaqs74%3D 18325493
39. RA Rescorla RL Solomon 1967 Two-process learning theory: relationships between Pavlovian conditioning and instrumental learning Psychol Rev 74 151 182 10.1037/h0024475 1:STN:280:DyaF2s3ltlyqsg%3D%3D 5342881
40. DJ Sanger 1985 The effects of clozapine on shuttle-box avoidance responding in rats: comparisons with haloperidol and chlordiazepoxide Pharmacol Biochem Behav 23 231 236 10.1016/0091-3057(85)90562-3 1:CAS:528: DyaL2MXltlGju7g%3D 4059310 (Pubitemid 16216446)
41. R Schreiber M Brocco V Audinot A Gobert S Veiga MJ Millan 1995 (1-(2, 5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists J Pharmacol Exp Ther 273 101 112 1:CAS:528:DyaK2MXltVGlt7s%3D 7714755
42. P Seeman T Lee M Chau-Wong K Wong 1976 Antipsychotic drug doses and neuroleptic/dopamine receptors Nature 261 717 719 10.1038/261717a0 1:CAS:528:DyaE28XlsFCisbk%3D 945467
43. LS Seiden LC Hanson 1964 Reversal of the reserpine-induced suppression of the conditioned avoidance response in the cat by l-DOPA Psychopharmacologia 6 239 244 10.1007/BF00413153 1:CAS:528:DyaF2MXjt1Crsw%3D%3D 5830803
44. LS Seiden DD Peterson 1968 Reversal of the reserpine-induced suppression of the conditioned avoidance response by l-dopa: correlation of behavioral and biochemical differences in two strains of mice J Pharmacol Exp Ther 159 422 428 1:CAS:528:DyaF1cXkvVajtg%3D%3D 5638661
45. TE Sipes MA Geyer 1995 DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT(2A) and not by 5-HT(2C) receptors Behav Pharmacol 6 839 842 10.1097/00008877-199512000-00010 1:CAS:528:DyaK28XhtVSgtbg%3D 11224388
46. TE Sipes MA Geyer 1997 DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum Brain Res 761 97 104 10.1016/S0006-8993(97)00316-8 1:CAS:528:DyaK2sXjslKmtr4%3D 9247071 (Pubitemid 27314738)
47. RL Smith RJ Barrett E Sanders-Bush 1999 Mechanism of tolerance development to 2, 5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor Psychopharmacology (Berl) 144 248 254 10.1007/s002130051000 1:CAS:528:DyaK1MXkslKks7s%3D (Pubitemid 29307276)
48. RL Smith RJ Barrett E Sanders-Bush 2003 Discriminative stimulus properties of 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6 J mice Psychopharmacology (Berl) 166 61 68 1:CAS:528: DC%2BD3sXhtFKlsbs%3D
49. HF Villanueva JH Porter 1993 Differential tolerance to the behavioral effects of chronic pimozide and clozapine on multiple random interval responding in rats Behav Pharmacol 4 201 208 10.1097/00008877-199306000-00002 1:CAS:528:DyaK3sXmtFOhtrs%3D 11224187
50. ML Wadenberg S Ahlenius 1995 Antagonism by the 5-HT2A/C receptor agonist DOI of raclopride-induced catalepsy in the rat Eur J Pharmacol 294 247 251 10.1016/0014-2999(95)00535-8 1:CAS:528:DyaK2MXhtVSgsb3F 8788438
51. ML Wadenberg PB Hicks 1999 The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics? Neurosci Biobehav Rev 23 851 862 10.1016/S0149-7634(99)00037-8 1:STN:280:DC%2BD3c%2FgslSksQ%3D%3D 10541060 (Pubitemid 29458891)
52. ML Wadenberg P Salmi P Jimenez T Svensson S Ahlenius 1996 Enhancement of antipsychotic-like properties of the dopamine D2 receptor antagonist, raclopride, by the additional treatment with the 5-HT2 receptor blocking agent, ritanserin, in the rat Eur Neuropsychopharmacol 6 305 310 10.1016/S0924-977X(96) 00035-1 1:CAS:528:DyaK28Xnt1KrtL0%3D 8985714 (Pubitemid 26422791)
53. MG Wadenberg JL Browning KA Young PB Hicks 2001 Antagonism at 5-HT(2A) receptors potentiates the effect of haloperidol in a conditioned avoidance response task in rats Pharmacol Biochem Behav 68 363 370 10.1016/S0091-3057(00) 00483-4 1:CAS:528:DC%2BD3MXivFens7s%3D 11325387 (Pubitemid 32452389)
54. ML Wadenberg A Soliman SC VanderSpek S Kapur 2001 Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects Neuropsychopharmacology 25 633 641 10.1016/S0893-133X(01) 00261-5 1:CAS:528:DC%2BD3MXnslCjsLc%3D 11682246 (Pubitemid 32995945)
55. FJ Wan NR Swerdlow 1993 Intra-accumbens infusion of quinpirole impairs sensorimotor gating of acoustic startle in rats Psychopharmacology (Berl) 113 103 109 10.1007/BF02244341 1:CAS:528:DyaK2cXktVSltbk%3D (Pubitemid 23341053)
56. DM Weiner ES Burstein N Nash GE Croston EA Currier KE Vanover SC Harvey E Donohue HC Hansen CM Andersson TA Spalding DF Gibson K Krebs-Thomson SB Powell MA Geyer U Hacksell MR Brann 2001 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics J Pharmacol Exp Ther 299 268 276 1:CAS:528: DC%2BD3MXntFWltb8%3D 11561089
57. NG Whitaker TD Lindstrom 1987 Disposition and biotransformation of quinpirole, a new D-2 dopamine agonist antihypertensive agent, in mice, rats, dogs, and monkeys Drug Metab Dispos 15 107 113 1:CAS:528:DyaL2sXhsVyqs7s%3D 2881745
58. C Zhao M Li 2009 The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors Pharmacol Biochem Behav 93 433 442 10.1016/j.pbb.2009.06.005 1:CAS:528:DC%2BD1MXpt1Kqsrw%3D 19539643