AGT genetic variation, plasma AGT, and blood pressure: An analysis of the utah genetic reference project pedigrees

American Journal of Hypertension

Volumn 23, Issue 8, 2010, Pages 917-923

  Watkins, W Scott ^a   Rohrwasser, Andreas ^a   Peiffer, Andy ^a   Leppert, Mark F ^a   Lalouel, Jean Marc ^a   Jorde, Lynn B ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

angiotensinogen; blood pressure; essential hypertension; haplotype; heritability; hypertension; plasma AGT

Indexed keywords

ANGIOTENSINOGEN; ANTIHYPERTENSIVE AGENT;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; CORRELATION ANALYSIS; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC VARIABILITY; HAPLOTYPE; HERITABILITY; HUMAN; HYPERTENSION; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PEDIGREE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; UNITED STATES; AGED; BLOOD; BLOOD PRESSURE; GENETICS; MIDDLE AGED; PEDIGREE;

ADULT; AGED; ANGIOTENSINOGEN; BLOOD PRESSURE; FEMALE; HAPLOTYPES; HUMANS; HYPERTENSION; LINKAGE (GENETICS); MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; GENETIC LINKAGE;

EID: 77955773315     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2010.83     Document Type: Article

References (26)

1. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In Laragh JH and Brenner BM (eds), Hypertension: Pathophysiology, Diagnosis, and Management, 2nd edn. Raven: New York, 1995, pp 67-88.
2. Hunt SC, Hasstedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR. Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol 1989; 129:625-638.
3. Kupper N, Ge D, Treiber FA, Snieder H. Emergence of novel genetic effects on blood pressure and hemodynamics in adolescence: the Georgia Cardiovascular Twin Study. Hypertension 2006; 47:948-954.
4. Majumder P P, Bhattacharya SK, Mukherjee BN, Rao DC. Genetic epidemiological study of blood pressure in a sedentary rural agricultural population of West Bengal, India. Am J Phys Anthropol 1990; 81:563-572.
5. Chien KL, Yang CY, Lee Y T. Major gene effects in systolic and diastolic blood pressure in families receiving a health examination in Taiwan. J Hypertens 2003; 21:73-79.
6. Rotimi CN, Cooper RS, Cao G, Ogunbiyi O, Ladipo M, Owoaje E, Ward R. Maximum-likelihood generalized heritability estimate for blood pressure in Nigerian families. Hypertension 1999; 33:874-878.
7. Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, Vasan RS, Mitchell GF. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet 2007; 8(Suppl 1):S3.
8. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton R P, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71:169-180.
9. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995; 92:2735-2739.
10. Jain S, Vinukonda G, Fiering SN, Kumar A. A haplotype of human angiotensinogen gene containing-217A increases blood pressure in transgenic mice compared with-217G. Am J Physiol Regul Integr Comp Physiol 2008; 295:R1849-R1857.
11. Vinck WJ, Fagard RH, Vlietinck R, Lijnen P. Heritability of plasma renin activity and plasma concentration of angiotensinogen and angiotensin-converting enzyme. J Hum Hypertens 2002; 16:417-422.
12. Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma AM, Gimenez-Roqueplo A P, Hata A, Corvol P, Lalouel JM. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 1997; 60:1448-1460.
13. Brand-Herrmann SM, Köpke K, Reichenberger F, Schmidt-Petersen K, Reineke T, Paul M, Zidek W, Brand E. Angiotensinogen promoter haplotypes are associated with blood pressure in untreated hypertensives. J Hypertens 2004; 22:1289-1297.
14. Watkins WS, Hunt SC, Williams GH, Tolpinrud W, Jeunemaitre X, Lalouel JM, Jorde LB. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J Hypertens 2010; 28:65-75.
15. White R, Leppert M, Bishop DT, Barker D, Berkowitz J, Brown C, Callahan P, Holm T, Jerominski L. Construction of linkage maps with DNA markers for human chromosomes. Nature 1985; 313:101-105.
16. Prescott SM, Lalouel JM, Leppert M. From linkage maps to quantitative trait loci: the history and science of the Utah genetic reference project. Annu Rev Genomics Hum Genet 2008; 9:347-358.
17. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
18. Elston RC. S.A.G.E. 6.0 Statistical Analysis for Genetic Epidemiology. Case Western Reserve University: Cleveland, OH, 2008.
19. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62:1198-1211.
20. Cooper RS, Guo X, Rotimi CN, Luke A, Ward R, Adeyemo A, Danilov SM. Heritability of angiotensin-converting enzyme and angiotensinogen: A comparison of US blacks and Nigerians. Hypertension 2000; 35:1141-1147.
21. Gordon MS, Chin WW, Shupnik MA. Regulation of angiotensinogen gene expression by estrogen. J Hypertens 1992; 10:361-366.
22. Fischer M, Baessler A, Schunkert H. Renin angiotensin system and gender differences in the cardiovascular system. Cardiovasc Res 2002; 53:672-677.
23. Asselbergs FW, Williams SM, Hebert PR, Coffey CS, Hillege HL, Navis G, Vaughan DE, van Gilst WH, Moore JH. The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels. Thromb Haemost 2006; 96:471-477.
24. Engeli S, Böhnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM. Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005; 45:356-362.
25. van Rijn MJ, Schut AF, Aulchenko YS, Deinum J, Sayed-Tabatabaei FA, Yazdanpanah M, Isaacs A, Axenovich TI, Zorkoltseva IV, Zillikens MC, Pols HA, Witteman JC, Oostra BA, van Duijn CM. Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes. J Hypertens 2007; 25:565-570.
26. Walker WG, Whelton PK, Saito H, Russell R P, Hermann J. Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension 1979; 1:287-291.